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Hypoxia, glucose metabolism and the Warburg’s effect
Journal of Bioenergetics and Biomembranes, 2007As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Ramon, Bartrons, Jaime, Caro
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New Compound Targets Warburg Effect
Cancer Discovery, 2015Abstract Researchers have developed a compound, SR9243, that kills cancer cells by inhibiting lipid production and the Warburg effect. The drug induces cell death in multiple types of cancer and does not cause the side effects that have derailed previous attempts to target these processes.
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Chronic lymphocytic leukemia and the Warburg effect
Blood, 2015In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
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Cellular life span and the Warburg effect
Experimental Cell Research, 2008Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo.
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Modulating Autophagy and the “Reverse Warburg Effect”
2014Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor to maintain cellular homeostasis and metabolism. The quality control of mitochondria is essential to maintain cell energy and this process appears to be achieved via ...
Vaccaro, Maria Ines +3 more
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A century of the Warburg effect
Nature Metabolism, 2023Craig B. Thompson +10 more
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The Warburg effect – Discovered 100 years ago
Free Radical Biology and Medicine, 2023Helmut Sies, Willem H. Koppenol
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