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Warburg and Krebs and related effects in cancer
Expert Reviews in Molecular Medicine, 2019AbstractWarburg and coworkers' observation of altered glucose metabolism in tumours has been neglected for several decades, which, in part, was because of an initial misinterpretation of the basis of their finding. Following the realisation that genetic alterations are often linked to metabolism, and that the tumour micro-environment imposes different ...
Judith E. Unterlass, Nicola J. Curtin
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Warburg effect and its role in tumourigenesis
Archives of Pharmacal Research, 2019Glucose is a crucial molecule in energy production and produces different end products in non-tumourigenic- and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose by fermentation and generate lactate and adenosine triphosphate even in the presence of oxygen (Warburg effect).
Maphuti T. Lebelo +2 more
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A century of the Warburg effect
Nature Metabolism, 2023Craig B. Thompson +10 more
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Chronic lymphocytic leukemia and the Warburg effect
Blood, 2015In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.
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Cellular life span and the Warburg effect
Experimental Cell Research, 2008Enhanced glycolysis is observed in most of cancerous cells and tissues, called as the Warburg effect. Recent advance in senescent biology implicates that the metabolic shift to enhanced glycolysis would be involved in the early stage during multi-step tumorigenesis in vivo.
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Hypoxia, glucose metabolism and the Warburg’s effect
Journal of Bioenergetics and Biomembranes, 2007As described by Warburg more than 50 years ago, tumour cells maintain a high glycolytic rate even in conditions of adequate oxygen supply. However, most of tumours are subjected to hypoxic conditions due to the abnormal vasculature that supply them with oxygen and nutrients. Thus, glycolysis is essential for tumour survival and spread.
Ramon, Bartrons, Jaime, Caro
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Modulating Autophagy and the “Reverse Warburg Effect”
2014Autophagy is a highly regulated cellular pathway for degrading long-lived proteins and is the only known pathway for clearing cytoplasmic organelles. Autophagy is a major contributor to maintain cellular homeostasis and metabolism. The quality control of mitochondria is essential to maintain cell energy and this process appears to be achieved via ...
Vaccaro, Maria Ines +3 more
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The Warburg Effect and Aerobic Glycolysis in Tumors
A basic metabolic characteristic of carcinogenesis, namely the Warburg effect, is defined by the preferred utilization of aerobic glycolysis for energy generation in cancer cells, even in the presence of oxygen. Here, rapid proliferation and carefully planned adaptation to fulfill biosynthetic, redox, and survival requirements of malignant ...Bhupender, Nehra +6 more
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