Results 31 to 40 of about 106,451 (346)

CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect

Journal of Experimental & Clinical Cancer Research, 2023
Background The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients.
Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan   +16 more
doaj   +1 more source

LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer

Frontiers in Cell and Developmental Biology, 2021
Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic ...
Li Li, Yan Ma, Kamalibaike Maerkeya, Davuti Reyanguly, Lili Han   +4 more
doaj   +1 more source

LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells.

PLoS ONE, 2019
The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako, Ntombikayise Xelwa, Monde Ntwasa   +2 more
doaj   +1 more source

Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect

Cell Transplantation, 2021
Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer.
Zhen Li, Lina Yang, Shuai Zhang, Jiaqi Song, Huanran Sun, Changliang Shan, Dan Wang, Shuangping Liu   +7 more
doaj   +1 more source

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]

, 2017
Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash, Corbett, Austin J, Jamshidi, Neema, Palsson, Bernhard O, Thomas, Alex, Zielinski, Daniel C   +5 more
core   +1 more source

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

Frontiers in Cellular and Infection Microbiology, 2020
Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming, Hayden T. Pacl, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn   +4 more
doaj   +1 more source

Postulates on electromagnetic activity in biological systems and cancer [PDF]

, 2013
A framework of postulates is formulated to define the existence, nature, and function of a coherent state far from thermodynamic equilibrium in biological systems as an essential condition for the existence of life. This state is excited and sustained by
Alberts, Albrecht-Buehler, Albrecht-Buehler, Amos, Amos, Baker, Beil, Bonnet, Chen, Damadian, Dehmelt, Del Giudice, Devlin, Fröhlich, Fröhlich, Fröhlich, Fröhlich, Fuchs, Guck, Hagan, Hameroff, Hölzel, Jan Pokorný, Jandová, Jandová, Jelínek, Jitka Kobilková, Jiří Pokorný, Kirson, Kwapień, Michelakis, Michor, Nakamura, Nakamura, Pavlides, Pelling, Penrose, Pohl, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Popp, Preparata, Priel, Sahu, Sahu, Seyfried, Toyokuni, Traill, Tuszyński, Tyner, Vedruccio, Wada, Wada, Warburg, Warburg, Yamada, Zheng   +69 more
core   +1 more source

The Warburg effect alters amino acid homeostasis in human retinal endothelial cells: implication for proliferative diabetic retinopathy

Scientific Reports, 2023
Proliferative diabetic retinopathy (PDR) remains a leading cause of blindness despite progress in screening and treatment. Recently, the Warburg effect, a metabolic alteration affecting amino acid (AA) metabolism in proliferating cells, has drawn ...
Andrew Gregory, Thangal Yumnamcha, Mohamed Shawky, Shaimaa Eltanani, Armaan Naghdi, Bing X. Ross, Xihui Lin, Ahmed S. Ibrahim   +7 more
doaj   +1 more source

The reverse warburg effect in osteosarcoma

Oncotarget, 2014
Osteosarcoma is a rare primary malignant tumor of the bone. It is a childhood cancer and has a peak incidence in the second decade of life. Unfortunately, osteosarcoma has a poor prognosis because of its metastatic dissemination to the bone and to the lung.
Federica, Sotgia, Ubaldo E, Martinez-Outschoorn, Michael P, Lisanti   +2 more
openaire   +2 more sources