Results 31 to 40 of about 47,258 (264)

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect

Frontiers in Cell and Developmental Biology, 2018
The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and ...
Elizabeth K. Wiese, Elizabeth K. Wiese, Taro Hitosugi, Taro Hitosugi   +3 more
doaj   +1 more source

Interferon-γ regulates immunosuppression in septic mice by promoting the Warburg effect through the PI3K/AKT/mTOR pathway

Molecular Medicine, 2023
Background The main cause of high mortality from sepsis is that immunosuppression leads to life-threatening organ dysfunction, and reversing immunosuppression is key to sepsis treatment. Interferon γ (IFNγ) is a potential therapy for immunosuppression of
Xu-zhe Fu, Yu Wang
doaj   +1 more source

Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors

Frontiers in Oncology, 2021
Reprogramming of metabolic priorities promotes tumor progression. Our understanding of the Warburg effect, based on studies of cultured cancer cells, has evolved to a more complex understanding of tumor metabolism within an ecosystem that provides and ...
Sayani Patra, Sayani Patra, Naveed Elahi, Naveed Elahi, Aaron Armorer, Aaron Armorer, Swathi Arunachalam, Swathi Arunachalam, Joshua Omala, Joshua Omala, Iman Hamid, Iman Hamid, Anthony W. Ashton, Anthony W. Ashton, David Joyce, Xuanmao Jiao, Xuanmao Jiao, Richard G. Pestell, Richard G. Pestell, Richard G. Pestell   +19 more
doaj   +1 more source

Warburg′s effect on solid tumors

Saudi Journal of Kidney Diseases and Transplantation, 2014
Lactic acidosis is the result of imbalance between the systemic formation of lactate and its hepatic metabolism. In cancer patients, lactic acidosis is mainly associated with hematologic malignancies (leukemia and lymphomas) and the mechanism is known as Warburg's effect.
Talal El Imad, Lara El Khoury, Abdallah Sassine Geara   +2 more
openaire   +3 more sources

Reevaluating Yeast Metabolism: Understanding Crabtree–Warburg Effects Differences with the snf1∆ Strain as a New Model of the Warburg Effect

Applied Sciences
The Crabtree and Warburg effects both involve elevated glycolytic flux and fermentation under aerobic conditions, yet their regulatory bases differ fundamentally.
Gerardo M. Nava, Karla I. Lira-de León, David G. García-Gutiérrez, Vanessa Sánchez-Quezada, Luis Alberto Madrigal-Perez   +4 more
doaj   +1 more source

Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis

Biology, 2021
Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence.
Batoul Abi Zamer, Wafaa Abumustafa, Mawieh Hamad, Azzam A. Maghazachi, Jibran Sualeh Muhammad   +4 more
doaj   +1 more source

Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy

Drugs and Drug Candidates, 2023
The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells.
Eduardo Angulo-Elizari, Leire Gaviria-Soteras, Irati Zubiri, Sandra Ramos-Inza, Carmen Sanmartin, Daniel Plano   +5 more
doaj   +1 more source

How DNA methylation affects the Warburg effect [PDF]

International Journal of Biological Sciences, 2020
Significant enhancement of the glycolysis pathway is a major feature of tumor cells, even in the presence of abundant oxygen; this enhancement is known as the Warburg effect, and also called aerobic glycolysis. The Warburg effect was discovered nearly a hundred years ago, but its specific mechanism remains difficult to explain.
Zhu, Xingxin, Xuan, Zefeng, Chen, Jun, Li, Zequn, Zheng, Shusen, Song, Penghong   +5 more
openaire   +2 more sources

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

Frontiers in Pharmacology, 2019
The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue.
Xiaoting Hong, Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan   +15 more
doaj   +1 more source

The reverse warburg effect in osteosarcoma

Oncotarget, 2014
Osteosarcoma is a rare primary malignant tumor of the bone. It is a childhood cancer and has a peak incidence in the second decade of life. Unfortunately, osteosarcoma has a poor prognosis because of its metastatic dissemination to the bone and to the lung.
Federica, Sotgia, Ubaldo E, Martinez-Outschoorn, Michael P, Lisanti   +2 more
openaire   +2 more sources