Results 31 to 40 of about 108,453 (351)
Frontiers in Cell and Developmental Biology, 2021 Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic ...
Li Li +4 more
doaj +1 more source
Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
PLoS ONE, 2019 The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako +2 more
doaj +1 more source
Cell Transplantation, 2021 Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer.
Zhen Li +7 more
doaj +1 more source
Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]
, 2017 Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash +5 more
core +1 more source
STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]
, 2018 Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F +7 more
core +2 more sources
Nuclear PKM2 regulates the Warburg effect [PDF]
Cell Cycle, 2013 Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms.
Weiwei, Yang, Zhimin, Lu
openaire +2 more sources
Warburg Effect and Cancer Survival
Journal of Student Research, 2021 Warburg effect is a major metabolic shift of glycolysis in cancer cells towards anaerobic fermentation. Key reaction here overproduces lactate from pyruvate catalyzed by lactate dehydrogenase-A (LDHA). Augmented Warburg effect and oncometabolism may contribute to cancer progression worsening patients’ survival.
William Panosyan +2 more
openaire +2 more sources
Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming. [PDF]
, 2016 The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor ...
Bagai, Rakesh +14 more
core +1 more source
The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Bhattacharya, Bhaskar +2 more
openaire +2 more sources