Results 31 to 40 of about 678,174 (319)

Can metabolic plasticity be a cause for cancer? Warburg–Waddington legacy revisited [PDF]

, 2011
Fermentation of glucose to lactate in the presence of sufficient oxygen, known as aerobic glycolysis or Warburg effect, is a universal phenotype of cancer cells.
A Brock, A Carnero, A Goel, A King, A Vazquez, AE Vaughn, AG Knudson Jr, AK Godwin, AK Murugan, AM Soto, AP Feinberg, B Laforge, B Mintz, BH Jiang, C Gancedo, CV Dang, D Basanta, D Molenaar, DG Hardie, DL Cook, DR Wolstenholme, DW Parsons, E Bustamante, F Chiara, G Kroemer, G Sriram, GL Semenza, GL Semenza, GL Semenza, GL Semenza, GL Wang, GL Wang, H Kondoh, H Yan, H Zhang, H Zhang, JD Potter, JE Dick, JM Evans, JM Rosen, JS Fang, JT Pronk, JW Kim, K Grønbaek, LM Merlo, M Bigl, M Prlic, MG Vander Heiden, MM Baldewijns, NK Kloosterhof, O Warburg, P Armitage, P Jaakkola, P Koivunen, PA Kenny, PC Nowell, PP Hsu, QP Ghani, R Bjerkvig, R Díaz-Ruiz, R Kemkemer, RA Gatenby, RA Gatenby, RG Jones, RJ Shaw, RK Bruick, RL Brinster, S Huang, S Kauffman, S Matoba, S Pavlides, S Weinhouse, S Zhao, SF Gilbert, SL Bowker, T Frick, T Pfeiffer, T Reya, T Wang, TJ Schulz, WC Hahn, WG Kaelin, WG Kaelin Jr, Y Zhao, Y Zhao   +84 more
core   +2 more sources

Dr. Otto Heinrich Warburg—Survivor of Ethical Storms

Rambam Maimonides Medical Journal, 2015
Otto Heinrich Warburg (1883–1970; not to be confused with the Zionist of the same name) was a member of an illustrious Jewish family, known for some five centuries.
George M. Weisz
doaj   +1 more source

Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect [PDF]

, 2015
OBJECTIVES: The Warburg effect, the switch from aerobic energy production to anaerobic glycolysis, promotes tumour proliferation and motility by inducing acidification of the tumour microenvironment.
Archetti, Archetti, Archetti, Archetti, Archetti, Archetti, Bach, Basanta, Basanta, Basanta, Bergers, Bhujwalla, Buchler, Casciari, Feron, Gambhir, Gatenby, Gatenby, Gatenby, Gatenby, Gillies, Griffiths, Hanahan, He, Ibrahim Hashim, Ibrahim Hashim, Kelloff, Kianercy, Kunkel, Lardner, Martin, Martin, Maynard Smith, Mochiki, Park, Patel, Pauwels, Perc, Postovit, Postovit, Rajendran, Robey, Rohzin, Rubin, Schornack, Semenza, Shi, Silva, Smallbone, Smallbone, Sonveaux, Tomlinson, Tomlinson, Warburg, Williams, Wojtkowiak   +55 more
core   +1 more source

The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer

Frontiers in Oncology, 2020
As shown in our previous study, SIRT6 promotes an aggressive phenotype and the epithelial-mesenchymal transition (EMT) in papillary thyroid cancer (PTC). In this study, we focused on the regulatory axis including SIRT6, autophagy, and the Warburg effect.
Zhou Yang, Renhong Huang, Xiyi Wei, Weiping Yu, Zhijun Min, Min Ye   +5 more
doaj   +1 more source

CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect

Journal of Experimental & Clinical Cancer Research, 2023
Background The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients.
Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan   +16 more
doaj   +1 more source

New horizons in modulating the radio-sensitivity of head and neck cancer - 100 years after Warburg’ effect discovery

Frontiers in Oncology, 2022
Tumor radiation resistance along with chemotherapy resistance is one of the main causes of therapeutic failure of radiotherapy-treated head and neck cancers.
Camil Ciprian Mireștean, Camil Ciprian Mireștean, Roxana Irina Iancu, Roxana Irina Iancu, Dragoș Petru Teodor Iancu, Dragoș Petru Teodor Iancu   +5 more
doaj   +1 more source

Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Cell Death and Disease, 2021
Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely
Rongkun Li, Hengchao Li, Lili Zhu, Xiaoxin Zhang, Dejun Liu, Qing Li, Bo Ni, Lipeng Hu, Zhigang Zhang, Yanli Zhang, Xu Wang, Shu-Heng Jiang   +11 more
doaj   +1 more source

The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect [PDF]

PeerJ, 2023
Objective To investigate the effect of the kinase inhibitor AT9283 on Burkitt lymphoma (BL) cells and elucidate the underlying mechanisms. Methods The effect of AT9283 on the proliferation of BL cell lines was tested using the MTT assay.
Kaiming Jiang, Lihong Bai, Canfei Wang, Xiang Xiao, Zhao Cheng, Hongling Peng, Sufang Liu   +6 more
doaj   +2 more sources

The Warburg effect: a balance of flux analysis [PDF]

Metabolomics, 2014
Cancer metabolism is characterized by increased macromolecular syntheses through coordinated increases in energy and substrate metabolism. The observation that cancer cells produce lactate in an environment of oxygen sufficiency (aerobic glycolysis) is a central theme of cancer metabolism known as the Warburg effect.
Vaitheesvaran, B, Xu, J, Yee, J, Lu, QY, Go, VL, Xiao, GG, Lee, WN   +6 more
openaire   +5 more sources

Mechanism of Warburg Effect and Its Effect on Tumor Metastasis

Chinese Journal of Lung Cancer, 2015
Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear,
Huijun WEI, Lili GUO, Lin LI, Qinghua ZHOU, Zhihao WU   +4 more
doaj   +1 more source