Results 31 to 40 of about 13,460,861 (391)
The Warburg effect and its role in cancer detection and therapy [PDF]
, 2009 The Warburg effect is a cellular phenomenon in cancer cells discovered by Otto Warburg in 1924. His findings showed that in normoxic conditions tumor cells primarily use glycolysis for energy production instead of mitochondrial oxidative phosphorylation ...
Christ, Ethan J.
core +2 more sources
The SIRT6-Autophagy-Warburg Effect Axis in Papillary Thyroid Cancer
Frontiers in Oncology, 2020 As shown in our previous study, SIRT6 promotes an aggressive phenotype and the epithelial-mesenchymal transition (EMT) in papillary thyroid cancer (PTC). In this study, we focused on the regulatory axis including SIRT6, autophagy, and the Warburg effect.
Zhou Yang +5 more
doaj +1 more source
The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect [PDF]
PeerJ, 2023 Objective To investigate the effect of the kinase inhibitor AT9283 on Burkitt lymphoma (BL) cells and elucidate the underlying mechanisms. Methods The effect of AT9283 on the proliferation of BL cell lines was tested using the MTT assay.
Kaiming Jiang +6 more
doaj +2 more sources
Dr. Otto Heinrich Warburg—Survivor of Ethical Storms
Rambam Maimonides Medical Journal, 2015 Otto Heinrich Warburg (1883–1970; not to be confused with the Zionist of the same name) was a member of an illustrious Jewish family, known for some five centuries.
George M. Weisz
doaj +1 more source
Frontiers in Oncology, 2022 Tumor radiation resistance along with chemotherapy resistance is one of the main causes of therapeutic failure of radiotherapy-treated head and neck cancers.
Camil Ciprian Mireștean +5 more
doaj +1 more source
bioRxiv, 2023 BACKGROUND & AIMS PDAC is characterized by significant matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, it is not clear the connection between matrix stiffness and the Warburg effect and the mechanisms of ...
Jiahao Zheng +15 more
semanticscholar +1 more source
Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
Glucose Metabolism in Cancer: The Warburg Effect and Beyond
Advances in Experimental Medicine and Biology, 2022 Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis ...
S. Bose, Cissy Zhang, A. Le
semanticscholar +1 more source
Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect. [PDF]
, 2015 Epidemiological and biochemical studies show that the sporadic forms of Alzheimer's disease (AD) are characterized by the following hallmarks: (a) An exponential increase with age; (b) Selective neuronal vulnerability; (c) Inverse cancer comorbidity. The
Demetrius, L.A. +2 more
core +4 more sources
Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
Chinese Journal of Lung Cancer, 2015 Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear,
Huijun WEI +4 more
doaj +1 more source