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Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
Chinese Journal of Lung Cancer, 2015 Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear,
Huijun WEI +4 more
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The Warburg Effect: 80 years on [PDF]
Biochemical Society Transactions, 2016 Influential research by Warburg and Cori in the 1920’s ignited interest in how cancer cells’ energy generation is different to normal cells’. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared to ...
Potter, Michelle +2 more
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Autophagy, Warburg, and Warburg reverse effects in human cancer [PDF]
BioMed Research International, 2014 Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism.
Ropolo, Alejandro Javier +5 more
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Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells
Drug Design, Development and Therapy, 2015 Shuai Han,* Shaohua Yang,* Zhai Cai, Dongyue Pan, Zhou Li, Zonghai Huang, Pusheng Zhang, Huijuan Zhu, Lijun Lei, Weiwei Wang Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China ...
Han S +9 more
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Partners in the Warburg effect [PDF]
eLife, 2016 Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.
Joshua D Rabinowitz, Hilary A Coller
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Warburg′s effect on solid tumors
Saudi Journal of Kidney Diseases and Transplantation, 2014 Lactic acidosis is the result of imbalance between the systemic formation of lactate and its hepatic metabolism. In cancer patients, lactic acidosis is mainly associated with hematologic malignancies (leukemia and lymphomas) and the mechanism is known as
Abdallah Sassine Geara +2 more
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Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect [PDF]
Frontiers in Cell and Developmental Biology, 2018 The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and ...
Elizabeth K. Wiese +3 more
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Reversing the Warburg effect as a treatment for glioblastoma [PDF]
Journal of Biological Chemistry, 2013 Glioblastoma multiforme (GBM), like most cancers, possesses a unique bioenergetic state of aerobic glycolysis known as the Warburg effect. Here, we documented that methylene blue (MB) reverses the Warburg effect evidenced by the increasing of oxygen ...
Winters, A +3 more
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Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect [PDF]
, 2011 The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily ...
Tomer Shlomi +14 more
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The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Bhattacharya, Bhaskar +2 more
openaire +2 more sources