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Mechanism of Warburg Effect and Its Effect on Tumor Metastasis
Chinese Journal of Lung Cancer, 2015 Cancer cells exhibit altered glucose metabolism characterized by a preference for aerobic glycolysis even when the oxygen content is normal, a phenomenon termed “Warburg effect”. However the definite molecular mechanisms of Warburg effect remains unclear,
Huijun WEI +4 more
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Anti-Warburg effect of rosmarinic acid via miR-155 in gastric cancer cells
Drug Design, Development and Therapy, 2015 Shuai Han,* Shaohua Yang,* Zhai Cai, Dongyue Pan, Zhou Li, Zonghai Huang, Pusheng Zhang, Huijuan Zhu, Lijun Lei, Weiwei Wang Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China ...
Han S +9 more
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Partners in the Warburg effect [PDF]
eLife, 2016 Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.
Joshua D Rabinowitz, Hilary A Coller
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Autophagy, Warburg, and Warburg Reverse Effects in Human Cancer [PDF]
BioMed Research International, 2014 Autophagy is a highly regulated-cell pathway for degrading long-lived proteins as well as for clearing cytoplasmic organelles. Autophagy is a key contributor to cellular homeostasis and metabolism. Warburg hypothesized that cancer growth is frequently associated with a deviation of a set of energy generation mechanisms to a nonoxidative breakdown of ...
González, Claudio Daniel +5 more
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The Warburg effect: 80 years on [PDF]
Biochemical Society Transactions, 2016 Influential research by Warburg and Cori in the 1920s ignited interest in how cancer cells' energy generation is different from that of normal cells. They observed high glucose consumption and large amounts of lactate excretion from cancer cells compared with normal cells, which oxidised glucose using mitochondria.
Morten, K, Potter, M, Newport, E
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Henri Frankfort, Aby Warburg and ‘Mythopoeic Thought’ [PDF]
, 2011 This is the text of a lunchtime lecture given at the Warburg Institute in the spring of 2004. It formed part of a series given by current members of staff which were devoted to the work of past Warburg scholars, and was intended to introduce the ...
Taylor, Paul
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Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect [PDF]
, 2011 The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily ...
Tomer Shlomi +14 more
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The epigenetic basis of the Warburg effect [PDF]
Epigenetics, 2010 Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of ...
Xian, Wang, Hongchuan, Jin
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The Warburg effect and drug resistance [PDF]
British Journal of Pharmacology, 2016 The Warburg effect describes the increased utilization of glycolysis rather than oxidative phosphorylation by tumour cells for their energy requirements under physiological oxygen conditions. This effect has been the basis for much speculation on the survival advantage of tumour cells, tumourigenesis and the microenvironment of tumours. More recently,
Bhattacharya, Bhaskar +2 more
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Dr. Otto Heinrich Warburg—Survivor of Ethical Storms
Rambam Maimonides Medical Journal, 2015 Otto Heinrich Warburg (1883–1970; not to be confused with the Zionist of the same name) was a member of an illustrious Jewish family, known for some five centuries.
George M. Weisz
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