Results 31 to 40 of about 9,923,041 (290)

Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors

Frontiers in Oncology, 2021
Reprogramming of metabolic priorities promotes tumor progression. Our understanding of the Warburg effect, based on studies of cultured cancer cells, has evolved to a more complex understanding of tumor metabolism within an ecosystem that provides and ...
Sayani Patra, Sayani Patra, Naveed Elahi, Naveed Elahi, Aaron Armorer, Aaron Armorer, Swathi Arunachalam, Swathi Arunachalam, Joshua Omala, Joshua Omala, Iman Hamid, Iman Hamid, Anthony W. Ashton, Anthony W. Ashton, David Joyce, Xuanmao Jiao, Xuanmao Jiao, Richard G. Pestell, Richard G. Pestell, Richard G. Pestell   +19 more
doaj   +1 more source

Nuclear receptors and the Warburg effect in cancer [PDF]

International Journal of Cancer, 2014
In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermentation (now termed aerobic glycolysis)
Thorne, JL, Campbell, MJ
openaire   +3 more sources

The reverse warburg effect in osteosarcoma

Oncotarget, 2014
Osteosarcoma is a rare primary malignant tumor of the bone. It is a childhood cancer and has a peak incidence in the second decade of life. Unfortunately, osteosarcoma has a poor prognosis because of its metastatic dissemination to the bone and to the lung.
Federica, Sotgia, Ubaldo E, Martinez-Outschoorn, Michael P, Lisanti   +2 more
openaire   +2 more sources

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect

Frontiers in Cell and Developmental Biology, 2018
The Warburg Effect, or aerobic glycolysis, is one of the major metabolic alterations observed in cancer. Hypothesized to increase a cell's proliferative capacity via regenerating NAD+, increasing the pool of glycolytic biosynthetic intermediates, and ...
Elizabeth K. Wiese, Elizabeth K. Wiese, Taro Hitosugi, Taro Hitosugi   +3 more
doaj   +1 more source

Interferon-γ regulates immunosuppression in septic mice by promoting the Warburg effect through the PI3K/AKT/mTOR pathway

Molecular Medicine, 2023
Background The main cause of high mortality from sepsis is that immunosuppression leads to life-threatening organ dysfunction, and reversing immunosuppression is key to sepsis treatment. Interferon γ (IFNγ) is a potential therapy for immunosuppression of
Xu-zhe Fu, Yu Wang
doaj   +1 more source

Reevaluating Yeast Metabolism: Understanding Crabtree–Warburg Effects Differences with the snf1∆ Strain as a New Model of the Warburg Effect

Applied Sciences
The Crabtree and Warburg effects both involve elevated glycolytic flux and fermentation under aerobic conditions, yet their regulatory bases differ fundamentally.
Gerardo M. Nava, Karla I. Lira-de León, David G. García-Gutiérrez, Vanessa Sánchez-Quezada, Luis Alberto Madrigal-Perez   +4 more
doaj   +1 more source

Genetic Mutations and Non-Coding RNA-Based Epigenetic Alterations Mediating the Warburg Effect in Colorectal Carcinogenesis

Biology, 2021
Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence.
Batoul Abi Zamer, Wafaa Abumustafa, Mawieh Hamad, Azzam A. Maghazachi, Jibran Sualeh Muhammad   +4 more
doaj   +1 more source

Brief von Moritz M. Warburg an Walter Arnold Abraham Dirichlet

, 1879
BRIEF VON MORITZ M. WARBURG AN WALTER ARNOLD ABRAHAM DIRICHLET Brief von Moritz M. Warburg an Walter Arnold Abraham Dirichlet ( -
Dirichlet, Walter Arnold Abraham, Warburg, Moritz M.   +1 more
core   +3 more sources

Unmasking the Warburg Effect: Unleashing the Power of Enzyme Inhibitors for Cancer Therapy

Drugs and Drug Candidates, 2023
The Warburg effect (or aerobic glycolysis), which was first described in 1926 by Otto Heinrich Warburg, consists of the change in glucose metabolism in cancer cells.
Eduardo Angulo-Elizari, Leire Gaviria-Soteras, Irati Zubiri, Sandra Ramos-Inza, Carmen Sanmartin, Daniel Plano   +5 more
doaj   +1 more source

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

Frontiers in Pharmacology, 2019
The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue.
Xiaoting Hong, Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan   +15 more
doaj   +1 more source