Results 31 to 40 of about 53,264 (296)
Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy
Frontiers in Cellular and Infection Microbiology, 2020 Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming +4 more
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Scientific Reports, 2023 Proliferative diabetic retinopathy (PDR) remains a leading cause of blindness despite progress in screening and treatment. Recently, the Warburg effect, a metabolic alteration affecting amino acid (AA) metabolism in proliferating cells, has drawn ...
Andrew Gregory +7 more
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Nuclear receptors and the
International Journal of Cancer, 2014 In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermentation (now termed aerobic glycolysis)
Thorne, JL, Campbell, MJ
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Microeconomics of Metabolism: The Warburg Effect as Giffen Behaviour [PDF]
Bulletin of Mathematical Biology, 2021 AbstractMetabolic behaviours of proliferating cells are often explained as a consequence of rational optimization of cellular growth rate, whereas microeconomics formulates consumption behaviours as optimization problems. Here, we pushed beyond the analogy to precisely map metabolism onto the theory of consumer choice.
Jumpei F. Yamagishi +1 more
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The reverse warburg effect in osteosarcoma
Oncotarget, 2014 Osteosarcoma is a rare primary malignant tumor of the bone. It is a childhood cancer and has a peak incidence in the second decade of life. Unfortunately, osteosarcoma has a poor prognosis because of its metastatic dissemination to the bone and to the lung.
Federica, Sotgia +2 more
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Molecular Medicine, 2023 Background The main cause of high mortality from sepsis is that immunosuppression leads to life-threatening organ dysfunction, and reversing immunosuppression is key to sepsis treatment. Interferon γ (IFNγ) is a potential therapy for immunosuppression of
Xu-zhe Fu, Yu Wang
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Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors
Frontiers in Oncology, 2021 Reprogramming of metabolic priorities promotes tumor progression. Our understanding of the Warburg effect, based on studies of cultured cancer cells, has evolved to a more complex understanding of tumor metabolism within an ecosystem that provides and ...
Sayani Patra +19 more
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Applied SciencesThe Crabtree and Warburg effects both involve elevated glycolytic flux and fermentation under aerobic conditions, yet their regulatory bases differ fundamentally.
Gerardo M. Nava +4 more
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Post-translational modifications and the Warburg effect [PDF]
Oncogene, 2013 Post-translational modification (PTM) is an important step of signal transduction that transfers chemical groups such as phosphate, acetyl and glycosyl groups from one protein to another protein. As most of the PTMs are reversible, normal cells use PTMs as a 'switch' to determine the resting and proliferating state of cells that enables rapid and tight
T, Hitosugi, J, Chen
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Biology, 2021 Colorectal cancer (CRC) development is a gradual process defined by the accumulation of numerous genetic mutations and epigenetic alterations leading to the adenoma-carcinoma sequence.
Batoul Abi Zamer +4 more
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