Results 21 to 30 of about 53,264 (296)
The epigenetic basis of the Warburg effect [PDF]
Epigenetics, 2010 Cancer development results from the accumulation of genetic and epigenetic changes. By interacting with intracellular signaling to promote carcinogenesis, epigenetic networks can actively transform cancer-promoting signals from tumor-permissive microenvironment to coordinate cellular proliferation and metabolism in the initiation and progression of ...
Xian, Wang, Hongchuan, Jin
openaire +2 more sources
Dr. Otto Heinrich Warburg—Survivor of Ethical Storms
Rambam Maimonides Medical Journal, 2015 Otto Heinrich Warburg (1883–1970; not to be confused with the Zionist of the same name) was a member of an illustrious Jewish family, known for some five centuries.
George M. Weisz
doaj +1 more source
The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect [PDF]
PeerJ, 2023 Objective To investigate the effect of the kinase inhibitor AT9283 on Burkitt lymphoma (BL) cells and elucidate the underlying mechanisms. Methods The effect of AT9283 on the proliferation of BL cell lines was tested using the MTT assay.
Kaiming Jiang +6 more
doaj +2 more sources
Journal of Experimental & Clinical Cancer Research, 2023 Background The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients.
Jun Zheng +16 more
doaj +1 more source
Frontiers in Oncology, 2022 Tumor radiation resistance along with chemotherapy resistance is one of the main causes of therapeutic failure of radiotherapy-treated head and neck cancers.
Camil Ciprian Mireștean +5 more
doaj +1 more source
Revisiting the Warburg Effect with Focus on Lactate
Cancers, 2022 Rewired metabolism is acknowledged as one of the drivers of tumor growth. As a result, aerobic glycolysis, or the Warburg effect, is a feature of many cancers. Increased glucose uptake and glycolysis provide intermediates for anabolic reactions necessary for cancer cell proliferation while contributing sufficient energy.
Eva Kocianova +2 more
openaire +2 more sources
Cell Death and Disease, 2021 Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely
Rongkun Li +11 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic ...
Li Li +4 more
doaj +1 more source
PLoS ONE, 2019 The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako +2 more
doaj +1 more source
Cell Transplantation, 2021 Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer.
Zhen Li +7 more
doaj +1 more source