Results 21 to 30 of about 9,923,041 (290)

Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness

Cell Death and Disease, 2021
Hypoxic microenvironment is common in solid tumors, particularly in pancreatic ductal adenocarcinoma (PDAC). The Warburg effect is known to facilitate cancer aggressiveness and has long been linked to hypoxia, yet the underlying mechanism remains largely
Rongkun Li, Hengchao Li, Lili Zhu, Xiaoxin Zhang, Dejun Liu, Qing Li, Bo Ni, Lipeng Hu, Zhigang Zhang, Yanli Zhang, Xu Wang, Shu-Heng Jiang   +11 more
doaj   +1 more source

New horizons in modulating the radio-sensitivity of head and neck cancer - 100 years after Warburg’ effect discovery

Frontiers in Oncology, 2022
Tumor radiation resistance along with chemotherapy resistance is one of the main causes of therapeutic failure of radiotherapy-treated head and neck cancers.
Camil Ciprian Mireștean, Camil Ciprian Mireștean, Roxana Irina Iancu, Roxana Irina Iancu, Dragoș Petru Teodor Iancu, Dragoș Petru Teodor Iancu   +5 more
doaj   +1 more source

Revisiting the Warburg Effect with Focus on Lactate

Cancers, 2022
Rewired metabolism is acknowledged as one of the drivers of tumor growth. As a result, aerobic glycolysis, or the Warburg effect, is a feature of many cancers. Increased glucose uptake and glycolysis provide intermediates for anabolic reactions necessary for cancer cell proliferation while contributing sufficient energy.
Eva Kocianova, Viktoria Piatrikova, Tereza Golias   +2 more
openaire   +2 more sources

CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect

Journal of Experimental & Clinical Cancer Research, 2023
Background The Warburg effect is well-established to be essential for tumor progression and accounts for the poor clinical outcomes of hepatocellular carcinoma (HCC) patients.
Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan   +16 more
doaj   +1 more source

LncRNA OIP5-AS1 Regulates the Warburg Effect Through miR-124-5p/IDH2/HIF-1α Pathway in Cervical Cancer

Frontiers in Cell and Developmental Biology, 2021
Hypoxia reprogrammed glucose metabolism affects the Warburg effect of tumor cells, but the mechanism is still unclear. Long-chain non-coding RNA (lncRNA) has been found by many studies to be involved in the Warburg effect of tumor cells under hypoxic ...
Li Li, Yan Ma, Kamalibaike Maerkeya, Davuti Reyanguly, Lili Han   +4 more
doaj   +1 more source

LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells.

PLoS ONE, 2019
The Warburg Effect has emerged as a potential drug target because, in some cancer cell lines, it is sufficient to subvert it in order to kill cancer cells.
Philemon Ubanako, Ntombikayise Xelwa, Monde Ntwasa   +2 more
doaj   +1 more source

Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect

Cell Transplantation, 2021
Energy metabolism programming is a hallmark of cancer, and serves as a potent target of cancer therapy. Valproic acid (VPA), a broad Class I histone deacetylases (HDACs) inhibitor, has been used as a therapeutic agent for cancer.
Zhen Li, Lina Yang, Shuai Zhang, Jiaqi Song, Huanran Sun, Changliang Shan, Dan Wang, Shuangping Liu   +7 more
doaj   +1 more source

The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect [PDF]

PeerJ, 2023
Objective To investigate the effect of the kinase inhibitor AT9283 on Burkitt lymphoma (BL) cells and elucidate the underlying mechanisms. Methods The effect of AT9283 on the proliferation of BL cell lines was tested using the MTT assay.
Kaiming Jiang, Lihong Bai, Canfei Wang, Xiang Xiao, Zhao Cheng, Hongling Peng, Sufang Liu   +6 more
doaj   +2 more sources

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy

Frontiers in Cellular and Infection Microbiology, 2020
Tuberculosis (TB) was responsible for more deaths in 2019 than any other infectious agent. This epidemic is exacerbated by the ongoing development of multi-drug resistance and HIV co-infection.
Bridgette M. Cumming, Hayden T. Pacl, Adrie J. C. Steyn, Adrie J. C. Steyn, Adrie J. C. Steyn   +4 more
doaj   +1 more source

The Warburg effect alters amino acid homeostasis in human retinal endothelial cells: implication for proliferative diabetic retinopathy

Scientific Reports, 2023
Proliferative diabetic retinopathy (PDR) remains a leading cause of blindness despite progress in screening and treatment. Recently, the Warburg effect, a metabolic alteration affecting amino acid (AA) metabolism in proliferating cells, has drawn ...
Andrew Gregory, Thangal Yumnamcha, Mohamed Shawky, Shaimaa Eltanani, Armaan Naghdi, Bing X. Ross, Xihui Lin, Ahmed S. Ibrahim   +7 more
doaj   +1 more source