Results 51 to 60 of about 106,451 (346)
Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]
, 2011 Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez +2 more
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PLoS Pathogens, 2014 In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the late ...
Mei-An Su +15 more
doaj +1 more source
The Warburg Effect in Diabetic Kidney Disease [PDF]
Seminars in Nephrology, 2018 Diabetic kidney disease (DKD) is the leading cause of morbidity and mortality in diabetic patients. Defining risk factors for DKD using a reductionist approach has proven challenging. Integrative omics-based systems biology tools have shed new insights in our understanding of DKD and have provided several key breakthroughs for identifying novel ...
Guanshi, Zhang +2 more
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Frontiers in Pharmacology, 2019 The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue.
Xiaoting Hong +15 more
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Correlation between the Warburg effect and progression of triple-negative breast cancer
Frontiers in Oncology, 2023 Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted therapy due to the negative expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2. Although targeted therapy and
Shaojun Liu +4 more
doaj +1 more source
Post-translational modifications and the Warburg effect [PDF]
Oncogene, 2013 Post-translational modification (PTM) is an important step of signal transduction that transfers chemical groups such as phosphate, acetyl and glycosyl groups from one protein to another protein. As most of the PTMs are reversible, normal cells use PTMs as a 'switch' to determine the resting and proliferating state of cells that enables rapid and tight
T, Hitosugi, J, Chen
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Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. [PDF]
PLoS ONE, 2015 Previously we have generated inducible liver tumor models by transgenic expression of Myc or xmrk (activated EGFR homolog) oncogenes in zebrafish. To investigate the interaction of the two oncogenes, we crossed the two transgenic lines and observed more ...
Zhen Li +4 more
doaj +1 more source
Hepatocellular carcinoma: Review of disease and tumor biomarkers. [PDF]
, 2016 © The Author(s) 2016.Hepatocellular carcinoma (HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative
Cox, IJ +8 more
core +1 more source
Synaptic Plasticity and the Warburg Effect [PDF]
Cell Metabolism, 2014 Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with an enrichment in the expression of genes involved in synaptic plasticity and remodeling processes.
openaire +3 more sources
Uncoupling the Warburg effect from cancer [PDF]
Proceedings of the National Academy of Sciences, 2010 A remarkable trademark of most tumors is their ability to break down glucose by glycolysis at a vastly higher rate than in normal tissues, even when oxygen is copious. This phenomenon, known as the Warburg effect, enables rapidly dividing tumor cells to generate essential biosynthetic building blocks such as nucleic acids, amino acids, and lipids from ...
Najafov, Ayaz, Alessi, Dario R.
openaire +3 more sources