Results 51 to 60 of about 108,453 (351)

An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.

PLoS Pathogens, 2014
In this study, we used a systems biology approach to investigate changes in the proteome and metabolome of shrimp hemocytes infected by the invertebrate virus WSSV (white spot syndrome virus) at the viral genome replication stage (12 hpi) and the late ...
Mei-An Su, Yun-Tzu Huang, I-Tung Chen, Der-Yen Lee, Yun-Chieh Hsieh, Chun-Yuan Li, Tze Hann Ng, Suh-Yuen Liang, Shu-Yu Lin, Shiao-Wei Huang, Yi-An Chiang, Hon-Tsen Yu, Kay-Hooi Khoo, Geen-Dong Chang, Chu-Fang Lo, Han-Ching Wang   +15 more
doaj   +1 more source

Postulates on electromagnetic activity in biological systems and cancer [PDF]

, 2013
A framework of postulates is formulated to define the existence, nature, and function of a coherent state far from thermodynamic equilibrium in biological systems as an essential condition for the existence of life. This state is excited and sustained by
Alberts, Albrecht-Buehler, Albrecht-Buehler, Amos, Amos, Baker, Beil, Bonnet, Chen, Damadian, Dehmelt, Del Giudice, Devlin, Fröhlich, Fröhlich, Fröhlich, Fröhlich, Fuchs, Guck, Hagan, Hameroff, Hölzel, Jan Pokorný, Jandová, Jandová, Jelínek, Jitka Kobilková, Jiří Pokorný, Kirson, Kwapień, Michelakis, Michor, Nakamura, Nakamura, Pavlides, Pelling, Penrose, Pohl, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Pokorný, Popp, Preparata, Priel, Sahu, Sahu, Seyfried, Toyokuni, Traill, Tuszyński, Tyner, Vedruccio, Wada, Wada, Warburg, Warburg, Yamada, Zheng   +69 more
core   +1 more source

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

Frontiers in Pharmacology, 2019
The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue.
Xiaoting Hong, Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan   +15 more
doaj   +1 more source

A genetic toolkit for the analysis of metabolic changes in Drosophila provides new insights into metabolic responses to stress and malignant transformation [PDF]

, 2019
Regulation of the energetic metabolism occurs fundamentally at the cellular level, so analytical strategies must aim to attain single cell resolution to fully embrace its inherent complexity.
Behrensen, C., Durrieu, Lucía, Gándara, Lautaro, Wappner, Pablo   +3 more
core   +1 more source

How DNA methylation affects the Warburg effect [PDF]

International Journal of Biological Sciences, 2020
Significant enhancement of the glycolysis pathway is a major feature of tumor cells, even in the presence of abundant oxygen; this enhancement is known as the Warburg effect, and also called aerobic glycolysis. The Warburg effect was discovered nearly a hundred years ago, but its specific mechanism remains difficult to explain.
Zhu, Xingxin, Xuan, Zefeng, Chen, Jun, Li, Zequn, Zheng, Shusen, Song, Penghong   +5 more
openaire   +2 more sources

Correlation between the Warburg effect and progression of triple-negative breast cancer

Frontiers in Oncology, 2023
Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted therapy due to the negative expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2. Although targeted therapy and
Shaojun Liu, Yuxuan Li, Meng Yuan, Qing Song, Min Liu   +4 more
doaj   +1 more source

Heterogeneity and proliferation of invasive cancer subclones in game theory models of the Warburg effect [PDF]

, 2015
OBJECTIVES: The Warburg effect, the switch from aerobic energy production to anaerobic glycolysis, promotes tumour proliferation and motility by inducing acidification of the tumour microenvironment.
Archetti, Archetti, Archetti, Archetti, Archetti, Archetti, Bach, Basanta, Basanta, Basanta, Bergers, Bhujwalla, Buchler, Casciari, Feron, Gambhir, Gatenby, Gatenby, Gatenby, Gatenby, Gillies, Griffiths, Hanahan, He, Ibrahim Hashim, Ibrahim Hashim, Kelloff, Kianercy, Kunkel, Lardner, Martin, Martin, Maynard Smith, Mochiki, Park, Patel, Pauwels, Perc, Postovit, Postovit, Rajendran, Robey, Rohzin, Rubin, Schornack, Semenza, Shi, Silva, Smallbone, Smallbone, Sonveaux, Tomlinson, Tomlinson, Warburg, Williams, Wojtkowiak   +55 more
core   +1 more source

The reverse warburg effect in osteosarcoma

Oncotarget, 2014
Osteosarcoma is a rare primary malignant tumor of the bone. It is a childhood cancer and has a peak incidence in the second decade of life. Unfortunately, osteosarcoma has a poor prognosis because of its metastatic dissemination to the bone and to the lung.
Federica, Sotgia, Ubaldo E, Martinez-Outschoorn, Michael P, Lisanti   +2 more
openaire   +2 more sources

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Acta Pharmaceutica Sinica B
Cancer reprogramming is an important facilitator of cancer development and survival, with tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation, even under sufficient oxygen supply condition.
Minru Liao, Dahong Yao, Lifeng Wu, Chaodan Luo, Zhiwen Wang, Jin Zhang, Bo Liu   +6 more
doaj   +1 more source

Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. [PDF]

PLoS ONE, 2015
Previously we have generated inducible liver tumor models by transgenic expression of Myc or xmrk (activated EGFR homolog) oncogenes in zebrafish. To investigate the interaction of the two oncogenes, we crossed the two transgenic lines and observed more ...
Zhen Li, Weiling Zheng, Hankun Li, Caixia Li, Zhiyuan Gong   +4 more
doaj   +1 more source