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Warfarin pharmacogenetics [PDF]

Trends in Cardiovascular Medicine, 2015
The cytochrome P450 (CYP) 2C9 and vitamin K epoxide reductase complex 1 (VKORC1) genotypes have been strongly and consistently associated with warfarin dose requirements, and dosing algorithms incorporating genetic and clinical information have been shown to be predictive of stable warfarin dose.
Julie A, Johnson, Larisa H, Cavallari
openaire   +2 more sources

Warfarin Pharmacogenetics [PDF]

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2008
Significant interest in the pharmacogenetics of warfarin therapy has been triggered with the recent package insert update that highlights the potential role of pharmacogenetics in improving the safety and effectiveness of warfarin. We review the evidence of the influence of the two key genes of interest, the cytochrome P450 2C9 gene, CYP2C9, and the ...
Nita A, Limdi, David L, Veenstra
openaire   +2 more sources

Structural Changes of Sodium Warfarin in Tablets Affecting the Dissolution Profiles and Potential Safety of Generic Substitution

Pharmaceutics, 2021
At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets.
Jan Muselík, Martina Urbanova, Eva Bartoníčková, Jakub Palovčík, David Vetchý, Jiří Czernek, Larisa Janisova, Nadiia Velychkivska, Aleš Franc, Jiří Brus   +9 more
doaj   +1 more source

A Case Of Late-onset Warfarin Induced Skin Necrosis Resulting In Mortality

Hitit Medical Journal, 2023
Warfarin-induced skin necrosis is a rare complication of warfarin therapy and is associated with high mortality. Here, we present a case of warfarin-induced skin necrosis, that was fatal in a 53-year-old female patient who was started on warfarin ...
Pınar Korkmaz, Sinem Bayrakçı
doaj   +1 more source

Machine learning models to predict the warfarin discharge dosage using clinical information of inpatients from South Korea

Scientific Reports, 2023
As warfarin has a narrow therapeutic window and obvious response variability among individuals, it is difficult to rapidly determine personalized warfarin dosage.
Heejung Choi, Hee Jun Kang, Imjin Ahn, Hansle Gwon, Yunha Kim, Hyeram Seo, Ha Na Cho, JiYe Han, Minkyoung Kim, Gaeun Kee, Seohyun Park, Osung Kwon, Jae-Hyung Roh, Ah-Ram Kim, Ju Hyeon Kim, Tae Joon Jun, Young-Hak Kim   +16 more
doaj   +1 more source

Drug interactions between ALK inhibitors and warfarin with concurrent use of bucolome: a case report

Journal of Pharmaceutical Health Care and Sciences, 2023
Background Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) isoenzymes 2C9 or 3A4.
Takashi Kato, Yusuke Kunimoto, Manabu Kitagawa, Yuichiro Asai, Tomoko Kimyo, Hiromasa Nakata, Mamoru Takahashi, Hirofumi Chiba, Hiroki Takahashi, Atsushi Miyamoto, Masahide Fukudo   +10 more
doaj   +1 more source

Mekanik Kalp Kapaklı Hastalarda Antikoagülan Kullanımı ve Warfarin Direnci

Ankara Medical Journal, 2015
Amaç: Mekanik kalp kapağı olan hastalarda warfarin direnci olanlar  tespit edildi ve bu hastalarda uygulanan tedavi seçenekleri değerlendirildi.Materyal ve Metot: Çalışmaya 2006-2014 yılları arasında ınr takipleri yapılan mekanik kalp kapağı takılmış 40 ...
Ergun Salman, Kemal Erdoğan, Muhammet Fethi Sağlam, Mete Hıdıroğlu   +3 more
doaj   +1 more source

Use of warfarin in long-term care: a systematic review

BMC Geriatrics, 2012
Background The use of warfarin in older patients requires special consideration because of concerns with comorbidities, interacting medications, and the risk of bleeding.
Neidecker Marjorie, Patel Aarti A, Nelson Winnie W, Reardon Gregory   +3 more
doaj   +1 more source

Simultaneous Characterization and Determination of Warfarin and Its Hydroxylation Metabolites in Rat Plasma by Chiral Liquid Chromatography-Tandem Mass Spectrometry

Pharmaceutics, 2022
Warfarin is extensively used for venous thromboembolism and other coagulopathies. In clinical settings, warfarin is administered as a mixture of S- and R-warfarin, and both enantiomers are metabolized by multiple cytochrome P450 enzymes into many ...
Shasha Jin, Zhihong Li, Qing Yang, Boyu Fang, Xiaoqiang Xiang, Chao Peng, Weimin Cai   +6 more
doaj   +1 more source

Enzyme polymorphism in warfarin dose management after pediatric cardiac surgery

Research in Cardiovascular Medicine, 2015
Background: Warfarin is an anticoagulant and is widely used for the prevention of thromboembolic events. Genetic variants of the enzymes that metabolize warfarin, i.e.
Avisa Tabib, Babak Najibi, Mohammad Dalili, Ramin Baghaei, Behzad Poopak   +4 more
doaj   +1 more source