Simultaneous Characterization and Determination of Warfarin and Its Hydroxylation Metabolites in Rat Plasma by Chiral Liquid Chromatography-Tandem Mass Spectrometry [PDF]
Pharmaceutics, 2022 Warfarin is extensively used for venous thromboembolism and other coagulopathies. In clinical settings, warfarin is administered as a mixture of S- and R-warfarin, and both enantiomers are metabolized by multiple cytochrome P450 enzymes into many ...
Shasha Jin +6 more
doaj +2 more sources
A Case Of Late-onset Warfarin Induced Skin Necrosis Resulting In Mortality
Hitit Medical Journal, 2023 Warfarin-induced skin necrosis is a rare complication of warfarin therapy and is associated with high mortality. Here, we present a case of warfarin-induced skin necrosis, that was fatal in a 53-year-old female patient who was started on warfarin ...
Pınar Korkmaz, Sinem Bayrakçı
doaj +1 more source
Patterns of warfarin use in subgroups of patients with atrial fibrillation: a cross-sectional analysis of 430 general practices in the United Kingdom. [PDF]
PLoS ONE, 2013 Despite the proven efficacy of warfarin, its use in patients with Atrial Fibrillation (AF) is reportedly low. We investigated the underuse and overuse of warfarin in the management of AF in general practices in the United Kingdom (UK) against the ...
Mohammed A Mohammed +4 more
doaj +1 more source
Scientific Reports, 2023 As warfarin has a narrow therapeutic window and obvious response variability among individuals, it is difficult to rapidly determine personalized warfarin dosage.
Heejung Choi +16 more
doaj +1 more source
Thromboembolic and neurologic sequelae of discontinuation of an antihyperlipidemic drug during ongoing warfarin therapy [PDF]
, 2017 Warfarin and antihyperlipidemics are commonly co-prescribed. Some antihyperlipidemics may inhibit warfarin deactivation via the hepatic cytochrome P450 system.
Bilker, Warren B. +5 more
core +2 more sources
Mekanik Kalp Kapaklı Hastalarda Antikoagülan Kullanımı ve Warfarin Direnci
Ankara Medical Journal, 2015 Amaç: Mekanik kalp kapağı olan hastalarda warfarin direnci olanlar tespit edildi ve bu hastalarda uygulanan tedavi seçenekleri değerlendirildi.Materyal ve Metot: Çalışmaya 2006-2014 yılları arasında ınr takipleri yapılan mekanik kalp kapağı takılmış 40 ...
Ergun Salman +3 more
doaj +1 more source
Drug interactions between ALK inhibitors and warfarin with concurrent use of bucolome: a case report
Journal of Pharmaceutical Health Care and Sciences, 2023 Background Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) isoenzymes 2C9 or 3A4.
Takashi Kato +10 more
doaj +1 more source
Use of warfarin in long-term care: a systematic review
BMC Geriatrics, 2012 Background The use of warfarin in older patients requires special consideration because of concerns with comorbidities, interacting medications, and the risk of bleeding.
Neidecker Marjorie +3 more
doaj +1 more source
Pharmaceutics, 2021 At present, the risk of generic substitutions in warfarin tablets is still being discussed. The aim of this study was to assess whether API interactions with commonly used excipients may affect the safety of generic replacement of warfarin sodium tablets.
Jan Muselík +9 more
doaj +1 more source
Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation [PDF]
, 2019 © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which ...
Arachchillage, Deepa RJ +7 more
core +3 more sources