Changing the approach to anticoagulant therapy in older patients with multimorbidity using a precision medicine approach [PDF]
, 2018 The ageing of the world population has resulted in an increase in the number of older patients with multimorbid conditions receiving multiple therapies.
Capi, Matilde +8 more
core +1 more source
Evaluation of CYP2C19 Clinical Decision Support Alerts to Guide P2Y12 Inhibitor Prescribing
Clinical Pharmacology &Therapeutics, EarlyView.P2Y12 inhibitor selection involves numerous factors, including CYP2C19 genetics, since evidence demonstrates reduced clopidogrel efficacy in patients with decreased or no function CYP2C19 variants. In 2020, Indiana University health embedded interruptive clinical decision support (CDS) alerts in the electronic health record (EHR) to recommend ...
Ashley N. Springer +14 more
wiley +1 more source
Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation. [PDF]
PLoS ONE, 2011 Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients.
Inna Y Gong +11 more
doaj +1 more source
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.
New England Journal of Medicine, 2005 BACKGROUND The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the gene encoding vitamin K epoxide reductase complex 1 (VKORC1) may affect the response to warfarin.
M. Rieder +9 more
semanticscholar +1 more source
Thrombolysis in a stroke patient on dabigatran anticoagulation: case report and synopsis of published cases [PDF]
, 2013 We present the case of an aphasic 77-year-old stroke patient with left distal M1 occlusion who received rt-PA for thrombolysis while on oral anticoagulant treatment with dabigatran (150 mg b.i.d.).
Abruscato, Mario Giovanni Rosario +3 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman +14 more
wiley +1 more source
Safety and effectiveness of apixaban compared to warfarin in dialysis patients
Research and Practice in Thrombosis and Haemostasis, 2018 Essentials The safety of apixaban in patients on dialysis is currently debated. Bleeding events were retrospectively compared for dialysis patients on warfarin vs apixaban.
D. Reed +5 more
semanticscholar +1 more source
Non-valvular atrial fibrillation and stroke : implications for management [PDF]
, 1995 Nonvalvular Atrial Fibrillation is more prevalent with increasing age. It is associated with a six-fold excess risk of stroke; and a cumulative lifetime stroke risk of 35%. 15% of ischaemic strokes are directly attributable to it.
Tilney, Myra Kay
core
Drug Points: Apparent interaction between warfarin and levonorgestrel used for emergency contraception [PDF]
, 2000 No abstract ...
Ellison, J. +3 more
core +2 more sources
Clinical Pharmacology &Therapeutics, EarlyView.Barriers to incorporating pharmacogenetics into routine clinical practice in the United States are well documented. Initial surveys by the Clinical Pharmacogenetics Implementation Consortium (CPIC) in 2009 and 2010 identified barriers across four key domains that have hindered the widespread adoption of clinical pharmacogenetic testing.
D. Max Smith +18 more
wiley +1 more source