Results 101 to 110 of about 162,494 (358)

Fibrin D-dimer, markers of coagulation activation and the risk of major ischaemic heart disease in the Caerphilly Study [PDF]

open access: yes, 2001
We have previously reported that plasma fibrin D-dimer (a marker of turnover of cross-linked Fibrin) showed a strong and independent association with incident ischaemic heart disease (IHD) in the Caerphilly Study cohort of 1,998 men a-ed 49-65.
Lowe, G.D.O.   +4 more
core   +1 more source

A Dose‐Aware Model for Revealing Dose‐Risk Relationship of Drug–Drug Interaction

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Drug–drug interaction (DDI) is a common cause of adverse drug events (ADEs). Despite real‐world data‐based studies have developed knowledge on DDI, the precise relationships between doses of two‐drug combinations exposure and the risks of ADEs remain largely unknown.
Yi Shi   +8 more
wiley   +1 more source

Number needed to treat for net clinical benefit of oral anticoagulants in Asian patients with atrial fibrillation

open access: yesJournal of Arrhythmia
Background Oral anticoagulants (OAC) can reduce ischemic stroke/systemic embolism (SSE) in patients with non‐valvular atrial fibrillation (AF) while increasing the risk of major bleeding. We aimed to analyze the number needed to treat for the net benefit
Rungroj Krittayaphong   +3 more
doaj   +1 more source

Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model‐Informed Dosing Recommendations for Anticancer Drugs

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Isavuconazole is a broad‐spectrum triazole approved for the treatment of invasive aspergillosis or mucormycosis in adults and children aged ≥ 1 year. Current prescribing information lacks guidance regarding the co‐administration of isavuconazole with anticancer drugs–limited by the availability of clinical drug–drug interaction (DDI) data in ...
Theunis C. Goosen   +6 more
wiley   +1 more source

ОЦЕНКА ТЕРАПЕВТИЧЕСКОЙ ЭФФЕКТИВНОСТИ ВАРФАРИНА ПРОИЗВОДСТВА ЗАО «КАНОНФАРМА ПРАДАКШЕН» (РОССИЯ)

open access: yesАрхивъ внутренней медицины, 2014
Warfarin by «Kanonpharma production» (Russia) and original Warfarin have the similar safety and tolerability. We need some increase of dose of Warfarin by «Kanonpharma production» to reach target rate of INR, then in case of original Warfarin usage.
М. В. Хруслов   +1 more
doaj   +1 more source

Spasmodic Dysphonia

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults. [PDF]

open access: yes, 2019
Adverse drug reactions (ADRs) contribute to hospitalization but data on its economic burden is scant. Pre-emptive pharmacogenetic (PGx) testing can potentially reduce ADRs and its associated costs.
Brunham, Liam R   +6 more
core   +1 more source

Influence of Preoperative Anatomical Characteristics on the Direction of Inflow Cannula in HeartMate 3

open access: yesArtificial Organs, EarlyView.
The IC direction in HM3 was influenced by the mitral valve height from the LV apex, distance between the LV apex and chest wall, and thoracic depth from the LV apex. Moreover, the IC direction in HM3 had little influence on the flow, PAWP and the survival rate of patients.
Shusuke Imaoka   +8 more
wiley   +1 more source

Comparison of Temporary Interruption of Warfarin Therapy for 3 and 5 days before Surgery in Thailand: A Randomized Controlled Trial

open access: yesSiriraj Medical Journal, 2017
Objective: The ACCP guideline 2008 recommended cessation of warfarin five days before surgery. However, based on the observation of the clinical practice at Siriraj Hospital, we suggested a shorter period of three days before surgery.
Angsu Chartrungsan   +12 more
doaj  

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