Results 141 to 150 of about 166,832 (321)

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

Sleep characteristics and self‐reported sleep quality in the oldest‐old: Results from a prospective longitudinal cohort study

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Little is known about the correlation between subjective perception and objective measures of sleep quality in particular in the oldest‐old. The aim of this study was to perform longitudinal home sleep monitoring in this age group, and to correlate results with self‐reported sleep quality.
Hugo Saner, Kevin Möri, Narayan Schütz, Philipp Buluschek, Tobias Nef   +4 more
wiley   +1 more source

Mechanism of exacerbation of traumatic brain injury under warfarin anticoagulation in male mice.

PLoS ONE
IntroductionTraumatic brain injury (TBI) is exacerbated in patients on antithrombotic medications, with warfarin leading to increased bleeding in some cases.
Yuki Tatara, Ken-Ichiro Nakao, Ryo Shimada, Kazuhiko Kibayashi   +3 more
doaj   +1 more source

073 ATRIAL FIBRILLATION ABLATION UNDER THERAPEUTIC WARFARIN IS SAFE WITH IMPROVED PATIENTS' EXPERIENCE AND POTENTIALLY COST-SAVING COMPARED TO BRIDGING LOW MOLECULAR WEIGHT HEPARIN [PDF]

, 2013
Khang‐Li Looi, Patrick M. Heck, Sharad Agarwal, David Begley, M S Virdee, Simon P. Fynn   +5 more
openalex   +1 more source

Pulsed Field Ablation for Atrial Fibrillation in Patients With Obesity: Procedural and Clinical Outcomes

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Background Procedural and clinical outcomes in patients with obesity undergoing catheter ablation for atrial fibrillation (AF) have been mixed. Clinical data in the context of pulsed field ablation (PFA) are currently limited in this patient cohort.
Francis J. Ha, Duron Prinsloo, Edwin Xu, Hui Chen Han, Nitesh Nerlekar, Adam J. Brown, Emily Kotschet   +6 more
wiley   +1 more source

Virtual left atrial appendage occlusion in paroxysmal atrial fibrillation during sinus rhythm predicts variable reductions in blood stasis

The Journal of Physiology, EarlyView.
Abstract figure legend Stasis before and after left atrial appendage occlusion (LAAO) in participants with high stasis and low stasis. Stasis is predominantly located in LAA and reduced after LAAO. But in the participant with high stasis, stasis remains close to the occlusion site, indicating a potential risk for device related thrombi.
Sophia Bäck, Jonas Lantz, Iulia Skoda, Lars O. Karlsson, Anders Persson, Carl‐Johan Carlhäll, Tino Ebbers   +6 more
wiley   +1 more source

Alternative therapy interaction with warfarin: what doctors should know

Кардиоваскулярная терапия и профилактика, 2010
Warfarin effectiveness and safety is substantially affected by concurrent therapy. This paper reviews the main mechanisms of warfarin interactions with other agents, which underlie adverse effect development: platelet dysfunction, gastro-intestinal ...
T. B. Kozlova, T. V. Taratuta, M. B. Aksenova, T. V. Khlevchuk   +3 more
doaj  

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Warfarin paradox [PDF]

British Dental Journal, 2013
openaire   +2 more sources

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source