Results 141 to 150 of about 185,181 (328)

Effects of Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background The original non–vitamin K antagonist oral anticoagulant (NOAC) trials in nonvalvular atrial fibrillation (AF) enrolled patients with native valve pathologies.
K. Pan, D. Singer, B. Ovbiagele, Yi-Ling Wu, Mohamed A. Ahmed, Meng Lee   +5 more
semanticscholar   +1 more source

Warfarin-related nephropathy [PDF]

Kidney International, 2012
To the Editor: In the July (2) 2011 issue, Brodsky et al.1 purport to demonstrate the consequences of warfarin-related nephropathy (WRN) among a retrospective cohort from the Ohio State University Medical Center. The cohort selection procedure was designed to yield cases of ‘presumptive’ WRN, but may have resulted in selection bias: patients who had a ...
openaire   +3 more sources

Patterns of Direct Oral Anticoagulant Use in Pediatric Patients: Results From a Multicenter National Database

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) have quickly gained favor due to oral availability, favorable risk profile, and reduced lab monitoring. This study aims to evaluate trends in DOAC use among pediatric patients with new venous thrombotic events (VTE) and factors associated with their selection.
Molly Mack, Frederico Xavier, Meghan McCormick   +2 more
wiley   +1 more source

Guidance for the practical management of warfarin therapy in the treatment of venous thromboembolism

Journal of Thrombosis and Thrombolysis, 2016
Venous thromboembolism (VTE) is a serious and often fatal medical condition with an increasing incidence. The treatment of VTE is undergoing tremendous changes with the introduction of the new direct oral anticoagulants and clinicians need to understand ...
D. Witt, N. Clark, S. Kaatz, T. Schnurr, J. Ansell   +4 more
semanticscholar   +1 more source

Detection of Vkorc1 single nucleotide polymorphisms indicates the presence of anticoagulant rodenticide resistance in Australia's introduced rats†

Pest Management Science, EarlyView.
Introduced rat species in Australia were tested for Vkorc1 gene mutations associated with anticoagulant rodenticide resistance. The widespread occurrence of Tyr25Phe suggests potential resistance is common in Rattus rattus. Image created with BioRender.com Abstract BACKGROUND Anticoagulant rodenticides (ARs) are used globally to manage pest rodent ...
Alicia F Gorbould, Quinton F Burnham, Michael T Lohr, Annette Koenders   +3 more
wiley   +1 more source

Comparison of Temporary Interruption of Warfarin Therapy for 3 and 5 days before Surgery in Thailand: A Randomized Controlled Trial

Siriraj Medical Journal, 2017
Objective: The ACCP guideline 2008 recommended cessation of warfarin five days before surgery. However, based on the observation of the clinical practice at Siriraj Hospital, we suggested a shorter period of three days before surgery.
Angsu Chartrungsan, Pansak Laksanabunsong, Akarin Nimmannit, Bundarika Bundarika Suwanawiboon, Naravat Poungvarin, Wanchai Wongkornrat, Kriangkrai Tantiwongkosri, Worawong Slisatkorn, Pranya Sakiyalak, Punnarerk Thongcharoen, Thaworn Subtaweesin, Somchai Sriyoschati, Teeravit Phanchaipetch   +12 more
doaj  

Major Bleeding Risk During Anticoagulation with Warfarin, Dabigatran, Apixaban, or Rivaroxaban in Patients with Nonvalvular Atrial Fibrillation.

Journal of Managed Care & Specialty Pharmacy, 2017
BACKGROUND The use of non-vitamin K oral anticoagulants (NOACs) has increased steadily following marketing approval; however, their relative safety in nonvalvular atrial fibrillation (NVAF) patients in real-world clinical practice remains unclear ...
G. Adeboyeje, G. Sylwestrzak, J. Barron, Jeff White, Alan Rosenberg, J. Abarca, Geoffrey Crawford, R. Redberg   +7 more
semanticscholar   +1 more source

A Multiple Imputation Workflow for Handling Missing Covariate Data in Pharmacometrics Modeling

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Covariate missingness is a prevalent issue in pharmacometrics modeling. Incorrect handling of missing covariates can lead to biased parameter estimates, adversely affecting clinical practice and drug development dosing decisions. Single imputation is usually favored by pharmacometricians for its simplicity, but it ignores the uncertainty about
My‐Luong Vuong, Geert Verbeke, Erwin Dreesen   +2 more
wiley   +1 more source

ANALYSIS OF STRUCTURAL FEATURES OF THE KETO-KETAL ISOMERS OF WARFARIN BY SPECTRAL METHODS

Разработка и регистрация лекарственных средств, 2019
As a result of the studies was shown that the relative ratios of isomers by integration in DMSO-d6: (S, R)-warfarin – (S, S)-warfarin – open chain warfarin are 70%: 28%: 2%; in СDCl3 are 45%: 40%: 15%.
A. Z. Abyshev, K. B. Nguyen, L. N. Zinchuk   +2 more
doaj  

Ascorbic acid-induced warfarin resistance after breast cancer surgery: a case report and literature review

Frontiers in Pharmacology
Warfarin is an anticoagulant that requires INR-based dosage adjustment. Ascorbic acid may impair warfarin effectiveness according to limited literature.
Pingfa Gao, Yang Shen, Ping Wu, Wenjie Lv, Wenjie Lv   +4 more
doaj   +1 more source