Results 221 to 230 of about 9,239,850 (271)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Donor Functional Warm Ischemic Time in Donation After Circulatory Death Organ Transplantation: Moving Beyond Arbitrary Thresholds. [PDF]

Transplantation
Ciere SP, de Jonge J, Dor FJMF.
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

The Effectiveness of Passive Half-Time Interventions on Simulated Second-Half Performance in Elite Youth Soccer Players. [PDF]

J Sports Sci Med
Skinner B, Munn EE, Roberts T, Reed RA, Thorpe RT.   +4 more
europepmc   +1 more source

Surface-EMG Amplitude Differences Before and After Scheduled University Team Training Following a Standardized Warm-Up in Male Collegiate Volleyball Players. [PDF]

J Clin Med
Migdał M, Wiacek M, Studnicki R.
europepmc   +1 more source

Effects of the FIFA 11 + warm-up programme on motor performance in U-15 female soccer players: a randomized controlled trial. [PDF]

BMC Sports Sci Med Rehabil
Aslan TV, Tufekci S, Aygun Y, Canpolat B, Yagin FH, Tufekci S, Gurer H, Alkhamees NH, Ibrahim ZM, Al-Mhanna SB.   +9 more
europepmc   +1 more source

Non-pharmacological interventions for blood pressure management in hypertensive patients: selection of exercise regimens-a systematic review and network meta-analysis. [PDF]

Front Endocrinol (Lausanne)
Lv R, Wang X, Li H, Yang Z, Ye L, Zhou M.   +5 more
europepmc   +1 more source

Effectiveness of Resistance Training in People With Down Syndrome: Systematic Review and Meta-Analysis. [PDF]

J Appl Res Intellect Disabil
Benzo Iglesias MJ, Torres Álamo L, Salazar A, Rocamora Pérez P, Lucena Antón DM.   +4 more
europepmc   +1 more source

Seasonal variation in the incidence of vitreous hemorrhage in proliferative diabetic retinopathy. [PDF]

PLoS One
Kim M, Park YH.
europepmc   +1 more source