Results 91 to 100 of about 7,173,151 (255)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Testing the Effectiveness of Monetary Policy in Malaysia Using Alternative Monetary Aggregation [PDF]

The capability of monetary aggregates to generate stable link with fundamental economic indicators verifies the effectiveness of monetary targeting. However, traditional monetary aggregates have become flawed when financial reforms take place.
Leong, Choi-Meng, Evan, Lau, Abu Mansor, Shazali, Puah, Chin-Hong   +3 more
core  

Soil Organic-Matter in Water-Stable Aggregates Under Different Soil-Management Practices

Agriculture, 2017
An experiment of different management practices in a commercial vineyard, which was established in 2006 in the locality of Nitra-Dražovce, Slovakia on Rendzic Leptosol, was used to evaluate the dynamics of soil organic-matter parameters during the years ...
Šimanský Vladimír, Horák Ján, Clothier Brent, Buchkina Natalya, Igaz Dušan   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Research for Soil Properties and Aggregates in Tea Plantation with Different Planting Patterns

Shuitu baochi yanjiu, 2012
In order to explore the influences of tea plantation reclamation on soil properties,and promote coordinated development with economy and soil and water conservation in mountainous,soil physical properties and aggregate characteristics of different ...
LIN Shao-xia1, ZHANG Qing-hai1, ZHANG Zhen-ming3, YANG Hong-bo1, WEN Xi-mei1, LIN Chang-hu2   +5 more
doaj  

The soil structural stability determined by the QuantiSlakeTest: Linkage with soil porosity, water-stable aggregate fractions and soil chemical properties

Geoderma
Recently, the QuantiSlakeTest (QST) was developed which records mass loss or gain of intact soil samples during submergence, but it is yet unclear how slaking relates quantitatively to soil structure.
Toon van Dael, Quinten Verwerft, Erik Smolders   +2 more
doaj   +1 more source

Medium-term Impact of Conservation Agriculture on Soil Organic Carbon and Water Stable Aggregates in a Rainfed Hilly Agro-ecosystem

International Journal of Bio-Resource and Stress Management, 2023
The impact of conservation agriculture production system (CAPS) on soil organic carbon, bulk density, water stable aggregates and dry season soil moisture content across the profile (0−5, 5−10 and 10−20 cm) was assessed at the end of the 3rd cropping ...
K. N. Mishra, Bidyashree Tripathy, P. K. Roul, S. N. Dash   +3 more
doaj  

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source