Results 71 to 80 of about 873,686 (310)

Water Quality Modelling in Water Distribution Systems: Pilot-Scale Measurements and Simulation

open access: yesEngineering Proceedings
We present the results of water quality measurements in a pilot-scale, continuously circulated test rig consisting of HDPE pipe segments, where pH, conductivity, turbidity, salinity, temperature, and dissolved oxygen were measured daily.
Csaba Hős   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Modelling the loss of nitrification inhibitor dosed in water distribution systems subject to pipe corrosion

open access: yes, 2012
Copper sulphate dosed as a nitrifier inhibitor in water distribution systems has encountered dramatic loss due to iron pipe corrosion. Chosen as the representative of iron corrosion products, ferric hydroxide flocs at low concentration (
Sathasivan, Arumugam (R17016)   +2 more
core  

Co-Design of Water Distribution Systems with Behind-the-Meter Solar

open access: yesEngineering Proceedings
The design of water distribution systems (WDSs) is crucial for ensuring a resilient water supply for the future. To improve the energy efficiency of WDSs, behind-the-meter (BTM) solar has been considered as an option.
Jiayu Yao   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

AI-Assisted Pump Operation for Energy-Efficient Water Distribution Systems

open access: yesEngineering Proceedings
Pumping water in water networks is generally the top energy demand for water systems. This study seeks to develop a large language model (LLM)-assisted framework for pump operation. Herein, ChatGPT was used to suggest pump control settings over 24 h that
Niuosha Hedaiaty Marzouny   +1 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Modelling water quality for water distribution systems

open access: yes, 1999
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Maintaining water quality in distribution systems has become a prominent issue in the study of water networks.
Maier, Stefan Heinrich
core  

CFD analysis of pharmaceutical water distribution systems: T-junctions [PDF]

open access: yes, 2006
High pure water systems are used in pharmaceutical and chemical industries. Deadlegs are generally found at points of use in distribution systems. The FDA suggests that the 6D rule is sufficient to help prevent microbial contamination, due to stagnant ...
Elmaghrum, Salem
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

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