Results 71 to 80 of about 425,315 (313)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Revisión de parámetros fisicoquímicos como indicadores de calidad y contaminación del agua

Ingeniería e Investigación, 2007
Con el fin de facilitar la interpretación de los datos físicos, químicos y biológicos, cada vez más agencias medio-ambientales, universidades e institutos recurren a los indices de calidad y contaminación del agua (ICA e ICO), los cuales mediante una ...
Natalia Eugenia Samboni Ruiz, Yesid Carvajal Escobar, Juan Carlos Escobar   +2 more
doaj  

Water quality assessment in an arid region using a water quality index

Water Science and Technology, 2009
Water quality of the Zayandehrud River, located in an arid region of central part of Iran, was assessed using National Sanitation Foundation Water Quality Index (NSF WQI) calculated by four aggregation methods. Water samples were collected monthly (July 2006 to June 2007) from eight stations in the middle of the river.
M Nemati, Varnosfaderany, N, Mirghaffary, E, Ebrahimi, A, Soffianian   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Quality Assessment of Some Bottled Water That Available in Erbil City, Iraq by Using Water Quality Index for Drinking Purposes

Science Journal of University of Zakho, 2013
Consumers are reacting with water quality problems by buying bottled water which is an expensive solution and only partially resolve the problem. Subsequently, sales of bottled water have increased dramatically in the last ten years; therefore this study
Janan Jabbar Toma
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Assessment of Ground Water Quality Using Fuzzy Based Water Quality Index

, 2022
Ground water is a vital source of fresh water in both urban and rural regions of the world. In Kerala, ground water meets the drinking needs of more than 60% population. Thrissur is the central district of Kerala, with a special well culture. Mostly each and every home has a dug well and ground water is the major source of drinking water in the ...
Gayathri M N, Dr. Minimol Pieus T
openaire   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Fervença river water quality evaluation – water quality index (WQI)

, 2022
Water is fundamental for the survival of every specie on planet Earth and is a crucial element of the environment. Water bodies, however, have degraded over time due to various natural and mainly human-polluting activities. As a result, water quality control is required to monitor and reduce polluting agents while maintaining river health. The adoption
openaire   +1 more source