Results 41 to 50 of about 3,597,926 (326)

Spatio-temporal characterization of drought variability in data-scarce regions using global precipitation data: a case study in Cauto river basin, Cuba

Scientific Reports
Drought is considered the most severe water-related disaster in the Cauto river basin, which is the longest river and the main agricultural producer in Cuba. Better understanding of drought characteristics is crucial to drought management.
Anh Phuong Tran, Bao Chung Tran, Siliennis Blanco Campbell, Nam Anh Nguyen, Dieu Hang Tran, Thanh Thuy Nguyen, Anh Duc Nguyen, Hong Son Duong   +7 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Risk Assessment of Yellow Muddy Water in High-Construction-Intensity Cities Based on the GIS Analytic Hierarchy Process Method: A Case Study of Guangzhou City

Land
During urbanisation, extensive production and construction activities encroach on ecological spaces, leading to changes in environmental structures and soil erosion.
Xichun Jia, Xuebing Jiang, Jun Huang, Le Li, Bingjun Liu, Shunchao Yu   +5 more
doaj   +1 more source

An Evaluation of the Effects of Dredging Within the Arkansas River Navigation System - Volume I - Introduction, Summary and Conclusions, and Recommendations [PDF]

, 1978
The foundation for the development of the Arkansas River was laid with the authorization of many upstream reservoirs in the comprehensive River and Harbor Act of 1946 signed by President Truman.
Research Center, Arkansas Water Resources
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

An efficient parallel runoff forecasting model for capturing global and local feature information

Scientific Reports
Artificial intelligence has significantly accelerated the development of hydrological forecasting. However, research on how to efficiently identify the physical characteristics of runoff sequences and develop forecasting models that simultaneously ...
Yang-hao Hong, Dong-mei Xu, Wen-chuan Wang, Hong-fei Zang, Xiao-xue Hu, Yan-wei Zhao   +5 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The declining cyanobacterial blooms in Lake Taihu (China) in 2021: The interplay of nutrients and meteorological determinants

Ecological Indicators, 2022
The cyanobacterial blooms are global environmental perils and have been extensively compounded and changeable in Lake Taihu with emerging significantly higher intensities during 2016–2019 than those in 2010–2015.
Wu Donghao, Chen Fangfei, Hu Jiaxin, Ji Guanning, Shi YaDong, Shen Aichun   +5 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Water resources

, 2015
Outgoing
Thomas Rauschenbach, Albrecht Gnauck, Oliver Krol, Thomas Bernard, Torsten Pfützenreuter   +4 more
  +5 more sources