Results 61 to 70 of about 7,173,192 (255)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Impacts of Alpine Grassland Degradation on Soil Aggregate Distribution and Stability in the Qinghai Lake Basin, Qinghai–Tibetan Plateau

Land
Under the influence of climate change and human activities, alpine grasslands in the Qinghai Lake basin have undergone a degradation trend over recent decades.
Jie Ma, Wei Wang, Yuan Han, Guoqing Niu, Xiaolong Li, Yuanjie Hu, Ping Zhang, Jifu Zhang, Xiang Liu   +8 more
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Reorganization from Kinetically Stable Aggregation States to Thermodynamically Stable Nanotubes of BINOL-derived Amphiphiles in Water [PDF]

, 2019
The synthesis and self-assembly behavior of newly designed BINOL-based amphiphiles is presented. With minor structural modifications, the aggregation of these amphiphiles could be successfully tuned to form different types of assemblies in water, ranging
Stuart, Marc C A; id_orcid, Feringa, Ben L, Tosi, Filippo, Smit, Hans, Chen, Jiawen   +4 more
core   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Kinetics of the process of ion exchange and specific adsorption in water-stable aggregates [PDF]

, 1996
The results of investigation of the kinetics of processes of potassium ion exchange and copper adsorption by water-stable aggregates of dark-gray forest soil are considered.
Mel'nikov L., Koposov G., Shinkarev A.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Humus Content and Composition in the Water-Stable Aggregates of Dark Gray Forest Soils

, 2020
Humus distribution and composition in different fractions of water-stable soil aggregates isolated from the samples of the humus horizon of dark gray forest soil were studied by the Han method.
Perepelkina E., Shinkarev A.
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Short-term effects of different fertilization measures on water-stable aggregates and carbon and nitrogen of tea garden soil [PDF]

, 2020
In order to study the effects of different fertilization measures on spring tea soil in Southwest Sichuan, five treatments were set up, including no fertilization (CK), full chemical nitrogen fertilizer (CN), 50% nitrogen fertilizer +30% organic ...
Junpu Chen, Liu Yang, Shengjie Huang, Wentao Guo, Chengyi Huang, Xinpeng Ma, Yi’an Chen, Ma Xinpeng, Huang Shengjie, Guo Wentao, Yang Liu, Chen Yi’an, Chen Junpu, Huang Chengyi   +13 more
core   +1 more source