Results 41 to 50 of about 7,352 (249)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Effects of Different Dietary Starch Sources and Digestible Lysine Levels on Carcass Traits, Serum Metabolites, Liver Lipid and Breast Muscle Protein Metabolism in Broiler Chickens

Animals, 2023
This study investigated the effects of digestible lysine (dLys) in different dietary starch sources on liver lipid metabolism and breast muscle protein metabolism in broiler chickens.
Caiwei Luo, Yanhong Chen, Dafei Yin, Jianmin Yuan   +3 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Validation of molecular markers for the analysis of genetic diversity of amylase content and gel consistency among representative rice varieties in Sri Lanka

Tropical Agricultural Research, 2015
Starch is the major storage compound in almost all cereals including rice (Oryza sativa L.) and is used as a primary source of energy for humans. Furthermore, it is the main determinant of the eating and cooking quality (ECQ) of rice as amylose content ...
H.K.D.H. Fernando, T.J.C. Kajenthini, S.P. Rebeira, T.C. Bamunuarachchige, H.A.M. Wickramasinghe   +4 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Use of the p-SINE1-r2 in inferring evolutionary relationships of Thai rice varieties with AA genome [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2006
In a previous study we described the prevalence and distribution in Thailand of the retroposon p- SINE1-r2, in the intron 10 of the waxy gene in cultivated and wild rice with the AA genome.
Preecha Prathepha, Supachai Samappito
doaj  

Mapping of the Waxy Bloom Gene in ‘Black Jewel’ in a Parental Linkage Map of ‘Black Jewel’ × ‘Glen Ample’ (Rubus) Interspecific Population

Agronomy, 2020
Black and red raspberries (Rubus occidentalis L. and Rubus idaeus L.) are the prominent members of the genus Rubus (Rosaceae family). Breeding programs coupled with the low costs of high-throughput sequencing have led to a reservoir of data that have ...
Dora Pinczinger, Marcel von Reth, Jens Keilwagen, Thomas Berner, Andreas Peil, Henryk Flachowsky, Ofere Francis Emeriewen   +6 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Prospects of using zein markers in breeding waxy maize lines and varieties

Труды по прикладной ботанике, генетике и селекции, 2019
Background. Among the numerous maize accessions in the VIR collection, Plant special attention is drawn to the lines and varieties of waxy maize due to their specific feature, that is, the content of high-quality grain starch that consists entirely of ...
V. V. Sidorova, Yu. A. Kerv, G. V. Matveeva, A. V. Konarev   +3 more
doaj   +1 more source

Identification of waxy genotype in sorghum genetic resources using waxy gene-based markers and iodine staining methods

Australian Journal of Crop Science, 2023
Sorghum is widely recognized as a versatile crop with significant value in the production of food and energy. Sorghum with waxy trait (low amylose) is more palatable to the food industries and more appealing to consumers than nonwaxy variety. However, waxy sorghum has not yet been introduced to Indonesia, making it difficult to use sorghum to support ...
Lizza Fauziah Suroya, Desta Wirnas, Trikoesoemaningtyas Trikoesoemaningtyas, Reflinur Reflinur   +3 more
openaire   +1 more source