Results 101 to 110 of about 2,466,381 (317)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2019 I am a fan of “weak theory,” as Paul Saint-Amour has described the constellation of engagements and scholarly endeavors that he brings together in his introduction to the “Weak Theory” special issue of Modernism/modernity.
Herring, Terrell Scott
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
GMM with many weak moment conditions [PDF]
Using many moment conditions can improve efficiency but makes the usual GMM inferences inaccurate. Two step GMM is biased. Generalized empirical likelihood (GEL) has smaller bias but the usual standard errors are too small.
Frank Windmeijer, Whitney Newey
core
On Weak Flexibility in Planar Graphs
, 2022 Recently, Dvořák, Norin, and Postle introduced flexibility as an extension of list coloring on graphs (J Graph Theory 92(3):191–206, 2019, https://doi.org/10.1002/jgt. 22447).
Murphy, Kyle +3 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Preference-Theoretic Weak Complementarity: Getting More with Less [PDF]
A preference-theoretic characterization of weak complementarity is provided based on an explicit representation of revealed preference. Weak complementarity is defined in terms of the observable property of nonessentiality and the unobservable property ...
David G. Brown
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Statistical methods in weak gravitational lensing
, 2015 This thesis studies several topics in the area of weak gravitational lensing and addresses some key statistical problems within this subject. A large part of the thesis concerns the measurement of galaxy shapes for weak gravitational lensing and the ...
Kacprzak, T
core
A Note on The Weak Sequential Core of Dynamic TU Games [PDF]
, 2010 This paper addresses a problem with an argument in Kranich, Perea, and Peters (2005) supporting their definition of the Weak Sequential Core and their characterization result.
Habis, H. +5 more
core +1 more source