Results 111 to 120 of about 2,466,381 (317)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cross-sectional Averaging and Instrumental Variable Estimation with Many Weak Instruments [PDF]

Instrumental variable estimation is central to econometric analysis and has justifiably been receiving considerable and consistent attention in the literature in the past.
George Kapetanios, Massimiliano Marcellino   +1 more
core  

Study on Anomalous Hall Effect and Spin–Orbit Torque Effect of TbCo-Based Multilayer Films

Nanomaterials
The anomalous Hall effect and spin–orbit torque of TbCo-based multilayer films have been methodically studied in recent years. Many properties of the films can be obtained by the anomalous Hall resistance loops of the samples. We report on the effects of
Menglu Yang, Yuanjing Qu, Tao He, Xiong He, Yunli Xu, Lizhi Yi, Liqing Pan, Guangduo Lu   +7 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Some Weaknesses of “Weaknesses of Undeniable Signatures” [PDF]

, 2007
The weaknesses that are the subject of [DY 91] have already been addressed in the published literature [C 90 & CvA 89]. The main class of these weaknesses consists of ways of cheating undeniable signatures; but these ways are shown here to themselves be "weak." Specifically, a cheater using them can double-cross the other cheaters, to the extent that ...
openaire   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Generalized empirical likelihood estimators and tests under partial, weak and strong identification [PDF]

The principal purpose of this paper is to describe the performance of generalized empirical likelihood (GEL) methods for time series instrumental variable models specified by nonlinear moment restrictions when identification may be weak.
Patrik Buggenberger, Richard Smith
core  

Preparation and Transport Properties of Mn_2.16Ga Single Crystal

Nanomanufacturing
In recent years, antiferromagnetic kagome materials have attracted considerable attention in condensed matter physics owing to their distinctive lattice geometry. In this work, high-quality single crystals of D019-structured Mn2.16Ga were grown using the
Chenyang Liu, Xiong He, Yunli Xu, Wenchang Wu, Yang Zou, Guangduo Lu, Lizhi Yi   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Bootstrap and Higher-Order Expansion Validity When Instruments May Be Weak [PDF]

It is well-known that size-adjustments based on Edgeworth expansions for the t-statistic perform poorly when instruments are weakly correlated with the endogenous explanatory variable.
Gustavo A. Suarez, Marcelo J. Moreira, Jack R. Porter   +2 more
core   +2 more sources