Results 71 to 80 of about 1,885,079 (269)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Property optimization of Er/Yb-codoped LiNbO3 crystals for LNOI lasers and amplifiers

APL Materials
Lithium-niobate-on-insulator (LNOI) is regarded as an ideal platform for integrated photonics. As an essential part, active devices based on rare-earth (RE) doped LNOI have made significant progress, with erbium/ytterbium-codoped lithium niobate (Er/Yb ...
Zhongzheng Zhang, Yuqi Zhang, Zhaojie Wu, Xin Yuan, Shiguo Liu, Hongde Liu, Dahuai Zheng, Yongfa Kong, Jingjun Xu   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On a weak form of weak quasi‐continuity [PDF]

International Journal of Mathematics and Mathematical Sciences, 2002
A weak form of weak quasi‐continuity, which we call subweak quasi‐continuity, is introduced. It is shown that subweak quasi‐continuity is strictly weaker than weak quasi‐continuity. Subweak quasi‐continuity is used to strengthen several results in the literature concerning weak quasi‐continuity.
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Concept of Contagiousness in the Ahādīth

Pakistan Journal of Islamic Research, 2018
A thorough study of the hadīth literature reveals that there are two broad categories of ahādīth regarding the concept of contagiousness. One set of ahādīth negates this conception while the other alludes to its occurrence. The phrase lā ‘adwā appears in
Muhammad Qasim Butt, Muhammad Sultan Shah   +1 more
doaj  

Suppressing laser-power noise with a multifunctional liquid crystal polarization grating in miniaturized optically pumped magnetometers

Microsystems & Nanoengineering
Optically pumped magnetometers (OPMs) enable high-resolution biomagnetic imaging, yet conventional single-beam designs are constrained by bulky, alignment-intensive polarization optics and susceptibility to laser-power noise.
Zhibo Cui, Xu Xiao, Zinan Wei, Zhimou Fu, Kun Huang, Liangsong Pei, Xiangyang Zhou, Zhen Chai, Dongbi Bai   +8 more
doaj   +1 more source

Are the Weak Channels Really Weak?

, 2009
The transfer probabilities for 20Ne + 90Zr and 20Ne + 92Zr at energies near the Coulomb barrier were measured. This quantity turned out to be very similar for both Zr isotopes and does not explain the observed differences in the barrier height distributions for these ...
Piasecki, E., Trzcińska, A., Gawlikowicz, W., Jastrzębski, J., Keeley, N., Kisieliński, M., Kliczewski, S., Kordyasz, A., Kowalczyk, M., Khlebnikov, S., Koshchiy, E., Kozulin, E., Krogulski, T., Lotkiev, T., Mutterer, M., Piasecki, K., Piórkowska, Aleksandra, Rusek, K., Staudt, A., Strojek, I., Trzaska, W.H., Sillanpaa, M., Smirnov, S., Tiourin, G., Hagino, K., Rowley, N.   +25 more
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source