Results 81 to 90 of about 5,954,666 (293)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Property optimization of Er/Yb-codoped LiNbO3 crystals for LNOI lasers and amplifiers

APL Materials
Lithium-niobate-on-insulator (LNOI) is regarded as an ideal platform for integrated photonics. As an essential part, active devices based on rare-earth (RE) doped LNOI have made significant progress, with erbium/ytterbium-codoped lithium niobate (Er/Yb ...
Zhongzheng Zhang, Yuqi Zhang, Zhaojie Wu, Xin Yuan, Shiguo Liu, Hongde Liu, Dahuai Zheng, Yongfa Kong, Jingjun Xu   +8 more
doaj   +1 more source

Feigning Weakness

International Organization, 2010
AbstractIn typical crisis bargaining models, strong actors must convince the opponent that they are not bluffing and the only way to do so is through costly signaling. However, in a war, strong actors can benefit from tactical surprise when their opponent mistakenly believes that they are weak.
openaire   +5 more sources

Weak core and central weak core inverse in a proper $*$-ring

, 2020
In this paper, we introduce the notion of weak core and central weak core inverse in a proper $*$-ring. We further elaborate on these two classes by producing a few representation and characterization of the weak core and central weak core invertible ...
Behera, Ratikanta, Das, Sourav, Sahoo, Jajati Keshari   +2 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Weak function word shift [PDF]

, 2004
The fact that object shift only affects weak pronouns in mainland Scandinavian is seen as an instance of a more general observation that can be made in all Germanic languages: weak function words tend to avoid the edges of larger prosodic domains.
Vogel, Ralf
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Deciphering light transformation in chiral metasurface in real space and time by ultrafast electron microscopy

Light: Science & Applications
Optical activity in chiral structures, i.e., circular dichroism (CD), has led to significant advances in nanoscale optical manipulation, including chiral metasurfaces, helicoid crystals, and chiral macromolecules.
Ling Tong, Fei Xie, Xiaochen Gao, Yuxuan Chen, Shaozheng Ji, Bin Zhang, Jing Li, Jiangteng Guo, Fang Liu, Cuntao Gao, Min Feng, Wei Wu, Shibin Deng, Yiming Pan, Yunquan Liu, Jingjun Xu, Mengxin Ren, Xuewen Fu   +17 more
doaj   +1 more source