Results 111 to 120 of about 2,496,982 (281)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

A discontinuous nonlinear singular elliptic problem with the fractional rho-Laplacian

open access: yesNonlinear Analysis
In this paper, we use the topological degree method, based on the abstract Hammerstein equation, to investigate the existence of weak solutions for a certain class of elliptic Dirichlet boundary value problems.
Ghizlane Zineddaine   +3 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

On Construction of Solutions of Hyperbolic Kirchhoff-Type Problems Involving Free Boundary and Volume Constraint

open access: yesMathematics
In this paper, we have undertaken the challenging and novel task of establishing the existence of weak solutions for four types of hyperbolic Kirchhoff-type problems: the classical hyperbolic Kirchhoff problem, the problem with a free boundary, the ...
Fatima Ezahra Bentata   +3 more
doaj   +1 more source

Sustainable bioplastics manufacturing from renewable sources

open access: yesFEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto   +6 more
wiley   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Weak Solutions for Dislocation Type Equations

open access: yes, 2008
We describe recent results obtained by G. Barles, P. Cardaliaguet, R. Monneau and the author recently. They are concerned with nonlocal Eikonal equations arising in the study of the dynamics of dislocation lines in crystals. These equations are nonlocal but also non monotone. We use a notion of weak solution to provide solutions for all time.
openaire   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Unilateral problems for the Klein-Gordon operator with nonlinearity of Kirchhoff-Carrier type

open access: yesElectronic Journal of Differential Equations, 2015
This work concerns the unilateral problem for the Klein-Gordon operator $$ \mathbb{L}=\frac{\partial^2 u}{\partial t^2}-M(|\nabla u|^2)\Delta u+M_1(|u|^2)u-f.
Carlos Raposo   +3 more
doaj  

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