Results 71 to 80 of about 10,780,423 (379)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Anisotropic singularity of solutions to elliptic equations in a measure framework
Electronic Journal of Differential Equations, 2015 In this article we study the weak solutions of elliptic equation $$\displaylines{ -\Delta u=2\frac{\partial \delta_0}{\partial \nu }\quad \text{in }\Omega,\cr u=0\quad \text{on }\partial\Omega, }$$ where $\Omega$ is an open bounded $C^2$ domain ...
Wanwan Wang, Huyuan Chen, Jian Wang
doaj
Weak Solution to KWC Systems of Pseudo-parabolic Type
Известия Иркутского государственного университета: Серия "Математика"In this paper, a class of systems of pseudo-parabolic PDEs is considered. These systems (S)ε are derived as a pseudo-parabolic dissipation system of Kobayashi– Warren–Carter energy, proposed by [Kobayashi et al., Physica D, 140, 141–150 (2000)], to ...
D. Mizuno
doaj +1 more source
Optimal control of a viscous generalized θ-type dispersive equation with weak dissipation
Open Mathematics, 2020 In this paper, we investigate the problem for optimal control of a viscous generalized θ\theta -type dispersive equation (VG θ\theta -type DE) with weak dissipation. First, we prove the existence and uniqueness of weak solution to the equation.
Fan Guobing, Yang Zhifeng
doaj +1 more source
Weak Solution for a Class of Fully Nonlinear Stochastic Hamilton-Jacobi-Bellman Equations [PDF]
, 2015 This paper is concerned with the stochastic Hamilton-Jacobi-Bellman equation with controlled leading coefficients, which is a type of fully nonlinear backward stochastic partial differential equation (BSPDE for short).
Qiu, Jinniao
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Existence of weak solutions for a non-homogeneous solidification mathematical model
Electronic Journal of Differential Equations, 2006 This article studies the existence of weak solutions for a stationary non-homogeneous system of equations describing the solidification process of a binary alloy confined to a regular bounded domain in $R^3$ and having mixed boundary conditions.
Elva Ortega-Torres, Mario M. Duran
doaj
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source