Results 81 to 90 of about 2,475,365 (332)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Weak solutions for p-Laplacian equation
Advances in Nonlinear Analysis, 2012 In this work we consider the p-Laplacian type parabolic equation with Dirichlet boundary condition and establish the existence of weak solutions using Leray–Schauder's fixed point theorem and semi-discretization process.
Bhuvaneswari Venkatasubramaniam +2 more
doaj +1 more source
Global weak solutions to the Navier-Stokes-Darcy-Boussinesq system for thermal convection in coupled free and porous media flows [PDF]
, 2021 Xiaoming Wang, Hao Wu
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Weak solutions and optimal controls of stochastic fractional reaction-diffusion systems
Open Mathematics, 2020 The aim of this paper is to investigate a class of nonlinear stochastic reaction-diffusion systems involving fractional Laplacian in a bounded domain. First, the existence and uniqueness of weak solutions are proved by using Galërkin’s method.
Fu Yongqiang, Yan Lixu
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Weak vorticity formulation for the incompressible Euler equations in domains with boundary
, 2013 In this article we examine the interaction of incompressible 2D flows with compact material boundaries. Our focus is the dynamic behavior of the circulation of velocity around boundary components and the possible exchange between flow vorticity and ...
Filho, Milton Lopes +3 more
core
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
On the regularity of weak solutions to $H$-systems
Rendiconti Lincei, Matematica e Applicazioni, 2007 In this paper we prove that every weak solution to the H -surface equation is locally bounded, provided the prescribed mean curvature H satisfies a suitable ...
openaire +5 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source