Results 91 to 100 of about 1,716,851 (287)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Weighted function spaces of fractional derivatives for vector fields

Electronic Journal of Differential Equations, 2007
We introduce and study weighted function spaces for vector fields from the point of view of the regularity theory for quasilinear subelliptic PDEs.
Andras Domokos
doaj  

Global weak solutions to the Vlasov-Poisson-Fokker-Planck-Navier-Stokes system

, 2022
Li Chen, Fucai Li, Yue Li, Nicola Zamponi   +3 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Existence and blow up for viscoelastic hyperbolic equations with variable exponents

Communications in Analysis and Mechanics
In this article, we consider a nonlinear viscoelastic hyperbolic problem with variable exponents. By using the Faedo$ - $Galerkin method and the contraction mapping principle, we obtain the existence of weak solutions under suitable assumptions on the ...
Ying Chu, Bo Wen, Libo Cheng
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A nonlinear wave equation with a nonlinear integral equation involving the boundary value

Electronic Journal of Differential Equations, 2004
We consider the initial-boundary value problem for the nonlinear wave equation $$displaylines{ u_{tt}-u_{xx}+f(u,u_{t})=0,quad xin Omega =(0,1 ...
Thanh Long Nguyen, Tien Dung Bui
doaj  

On weak solutions of semilinear hyperbolic-parabolic equations

International Journal of Mathematics and Mathematical Sciences, 1996
In this paper we prove the existence and uniqueness of weak solutions of the mixed problem for the nonlinear hyperbolic-parabolic equation (K1(x,t)u′)′+K2(x,t)u′+A(t)u+F(u)=f with null Dirichlet boundary conditions and zero initial data, where F(s) is a
Jorge Ferreira
doaj   +1 more source

Invariant manifolds for weak solutions to stochastic equations [PDF]

, 2000
Damir Filipović
openalex   +1 more source