Results 81 to 90 of about 499,052 (176)
An Ancestral Mechanism of Calmodulin Binding to Cds1 Kinase Inhibits Catalytic Activity
IUBMB Life, Volume 78, Issue 8, August 2026.ABSTRACT Calmodulin is a highly conserved, calcium (Ca2+) sensor protein that is ubiquitous among eukaryotes. Ca2+ binding to Calmodulin induces a conformational change that facilitates interaction with, and activation of, serine/threonine protein kinases, including members of the CaMK family.
Stephanie A. Manovella +12 more
wiley +1 more source
The overlooked greatwall: a new perspective on mitotic control [PDF]
Open Biology, 2012 The role of the dual specificity protein phosphatase, Cdc25, in activating the cyclin-dependent kinase-cyclin B complex (Cdk1-CycB) by overcoming the inhibitory Wee1 kinase is a long-established principle for mitotic entry.
David M. Glover
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.ABSTRACT We investigated the potential of miR‐640 to downregulate CDK4/6 inhibitor resistance‐associated genes and evaluated its apoptotic, anti‐metastatic and anti‐proliferative effects, both alone and in combination with abemaciclib in breast cancer cells. miR‐640 was identified via GSE126125 dataset analysis.
Ismail Mert Alkac, Cigir Biray Avci
wiley +1 more source
Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast. [PDF]
PLoS Genetics, 2015 A surveillance mechanism, the S phase checkpoint, blocks progression into mitosis in response to DNA damage and replication stress. Segregation of damaged or incompletely replicated chromosomes results in genomic instability.
Gloria Palou +5 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.ABSTRACT Toxoplasma gondii infection poses potential risks to stem cell‐based therapeutic applications; however, the effects of parasite‐derived soluble factors on mesenchymal stem cells remain unclear. Here, we investigated the impact of T. gondii‐derived soluble factors (Tg‐SFs) on human umbilical cord‐derived mesenchymal stem cells (hUC‐MSCs).
Wei Zhou +7 more
wiley +1 more source
Novel insights into maintaining genomic integrity: Wee1 regulating Mus81/Eme1
Cell Division, 2011 Maintenance of genomic integrity is essential for cell survival. Specifically, during DNA replication cells use a complex network of mechanisms that prevents genomic instability.
Martín Yusé +2 more
doaj +1 more source
A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target
Journal of Hematology & Oncology, 2020 The inhibition of the DNA damage response (DDR) pathway in the treatment of cancer has recently gained interest, and different DDR inhibitors have been developed. Among them, the most promising ones target the WEE1 kinase family, which has a crucial role
Andrea Ghelli Luserna di Rorà +3 more
doaj +1 more source
Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer. [PDF]
Oncotarget, 2016 Wee1 is a member of the Serine/Threonine protein kinase family and is a key regulator of cell cycle progression. It has been known that WEE1 is highly expressed and has oncogenic functions in various cancers, but it is not yet studied in gastric cancers.
Kim HY +6 more
europepmc +5 more sources
Early‐Phase Research in Pediatric Neuro‐Oncology
Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.
Jonathan Cunningham
wiley +1 more source
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 39, 13 July 2026.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source