Results 71 to 80 of about 499,052 (176)
Molecular control of the Wee1 regulatory pathway by the SAD kinase Cdr2 [PDF]
Journal of Cell Science, 2015 Cell growth and division are tightly coordinated to maintain cell size constant during successive cell cycles. In S.pombe the SAD kinase Cdr2 regulates cell size at division and division plane positioning. Cdr2 forms nodes on the medial cortex containing an inhibitory pathway for Wee1, under the negative control of polar gradients of the DYRK kinase ...
Mercè, Guzmán-Vendrell +4 more
openaire +2 more sources
Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation [PDF]
, 1997 Cytolethal distending toxins (CDT) constitute an emerging heterogeneous family of bacterial toxins whose common biological property is to inhibit the proliferation of cells in culture by blocking their cycle at G2/M phase.
Pérès, Sylvie Yvonne +10 more
core
The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation
Cell Reports, 2020 Summary: Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis.
Sarah Lockhead +7 more
doaj +1 more source
Targeting Cell Cycle Vulnerabilities in Cancers: Emerging Strategies for Therapeutic Development
Cancer Science, Volume 117, Issue 9, Page 2335-2344, September 2026.Dysregulated cell cycle control often involves alternative compensatory pathways in cancers to maintain its robustness but provide unique targetable vulnerabilities. We overview recent insights on cancer‐specific vulnerabilities across the cell cycle and discuss how these can be used to develop new therapeutic strategies.
Nana Kamakura +3 more
wiley +1 more source
International Journal of Biological Sciences, 2006 Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry.
Yohei Tominaga, Cuiling Li, Rui-Hong Wang, Chu-Xia Deng
doaj
Haematologica, 2014 Novel combinations targeting new molecular vulnerabilities are needed to improve the outcome of patients with acute myeloid leukemia. We recently identified WEE1 kinase as a novel target in leukemias.
Leena Chaudhuri +13 more
doaj +1 more source
Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
Journal of Hematology & Oncology, 2018 Background Despite the recent progress that has been made in the understanding and treatment of acute lymphoblastic leukemia (ALL), the outcome is still dismal in adult ALL cases.
Andrea Ghelli Luserna Di Rorà +23 more
doaj +1 more source
G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells
Radiation Oncology, 2023 Background The gene of the Epidermal growth factor receptor (EGFR) is one of the most frequently altered genes in glioblastoma (GBM), with deletions of exons 2–7 (EGFRvIII) being amongst the most common genomic mutations.
Meryem H. Cetin +13 more
doaj +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth +10 more
wiley +1 more source
miR-138-5p Inhibits the Growth and Invasion of Glioma Cells by Regulating WEE1
Analytical Cellular Pathology, 2022 Background. Accumulating evidence has demonstrated the role of differentially expressed miRNAs in glioma progression. Our previous bioinformatics analyses revealed a role of miR-138-5p in glioma.
Jianwu Gong +7 more
doaj +1 more source