Results 51 to 60 of about 499,052 (176)

Structural conservation of WEE1 and its role in cell cycle regulation in plants

Scientific Reports, 2021
The WEE1 kinase is ubiquitous in plant development and negatively regulates the cell cycle through phosphorylations. However, analogies with the control of the human cell cycle by tyrosine- (Tyr-) phosphorylation of cyclin-dependent kinases (CDKs) are ...
A. Détain, D. Redecker, N. Leborgne-Castel, S. Ochatt   +3 more
doaj   +1 more source

Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases [PDF]

Molecules, 2017
In the cell cycle, there are two checkpoint arrests that allow cells to repair damaged DNA in order to maintain genomic integrity. Many cancer cells have defective G1 checkpoint mechanisms, thus depending on the G2 checkpoint far more than normal cells.
Matthias Schmidt, Alexander Rohe, Charlott Platzer, Abdulkarim Najjar, Frank Erdmann, Wolfgang Sippl   +5 more
openaire   +4 more sources

Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA Damage

Microorganisms, 2020
The widely consumed neuroactive compound caffeine has generated much interest due to its ability to override the DNA damage and replication checkpoints.
John P. Alao, Johanna Johansson-Sjölander, Charalampos Rallis, Per Sunnerhagen   +3 more
doaj   +1 more source

Wee1 Inhibitor AZD1775 Effectively Inhibits the Malignant Phenotypes of Esophageal Squamous Cell Carcinoma In Vitro and In Vivo

Frontiers in Pharmacology, 2019
Esophageal squamous cell carcinoma (ESCC) is a common malignant diagnosed cancer with increasing incidence rate and few treatment options. As a specific small-molecule inhibitor of the Wee1 tyrosine kinase, AZD1775 has previously shown potent antitumor ...
Shuning Bi, Qiuren Wei, Zhijun Zhao, Liang Chen, Chaojie Wang, Songqiang Xie   +5 more
doaj   +1 more source

Wee1 kinase is expressed in moderately to poorly differentiated HCC.

, 2014
A-C, Wee1 kinase was stained with anti-Wee1 antibodies in surgically resected HCC samples (▾ HCC lesion). Anti-Wee1 antibody staining revealed mostly nuclear localization in Wee1 kinase-positive cells.
Tomomi Kogiso (588185), Hikaru Nagahara (588186), Etsuko Hashimoto (158662), Keiko Shiratori (588189), Masakazu Yamamoto (588188), Shunichi Ariizumi (588187)   +5 more
core   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science
Atherosclerosis has an urgent need for new therapeutic targets. Protein kinases orchestrate multiple cellular events in atherosclerosis and may provide new therapeutic targets for atherosclerosis. Here, a protein kinase, WEE1 G2 checkpoint kinase (WEE1),
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
doaj   +1 more source

Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma

Frontiers in Pharmacology, 2018
WEE1 is a tyrosine kinase that regulates G2/M cell cycle checkpoint and frequently overexpressed in various tumors. However, the expression and clinical significance of WEE1 in human laryngeal squamous cell carcinoma (LSCC) are still unknown.
Meng-Ling Yuan, Pei Li, Zi-Hao Xing, Jin-Ming Di, Hui Liu, An-Kui Yang, Xi-Jun Lin, Qi-Wei Jiang, Yang Yang, Jia-Rong Huang, Kun Wang, Meng-Ning Wei, Yao Li, Jin Ye, Zhi Shi   +14 more
doaj   +1 more source

Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up‐regulation

Molecular Oncology, 2021
Platinum‐based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1)
Xiaoliang Zhao, In‐Kyu Kim, Bhaskar Kallakury, Joeffrey J. Chahine, Eiji Iwama, Mariaelena Pierobon, Emanuel Petricoin, Justine N. McCutcheon, Yu‐Wen Zhang, Shigeki Umemura, Vincent Chen, Changli Wang, Giuseppe Giaccone   +12 more
doaj   +1 more source

Proto‐Panic Modulation by Caffeine‐Proteinoid Complexes

Journal of Applied Polymer Science, EarlyView.
Caffeine–proteinoid microspheres synthesized by thermal polymerization exhibit compartmentalized drug loading with encapsulation efficiencies of 61%–82% and triphasic release kinetics. Electrochemical monitoring reveals multi‐scale oscillatory dynamics consistent with chaotic and damped harmonic behavior, while Boolean logic operations demonstrate ...
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Investigation into Sustainability of WEE1 Kinase in Plants

Phosphoregulation is essential for the control of cell division. In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of CDK by WEE1 kinase.
Cook, Gemma S.
core   +6 more sources