YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
PLoS Biology, 2020 The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay ...
Qili Fei +4 more
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Construction and expression of Wee1 recombinant protein in Escherichia coli strain BL21 (DE3)
Jurnal Ilmu Dasar, 2023 Wee1 is a gene encoding for protein kinase that is located in the nucleus and it plays an essential role in determining the timing of mitosis. Overexpression of Wee1 in rice is resulting in increased plant size.
Ladefa Primana Oktapan +3 more
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Cdc5 Interacts with the Wee1 Kinase in Budding Yeast [PDF]
Molecular and Cellular Biology, 2001 Development of a multicellular organism requires that mitosis and morphogenesis be coordinated. These processes must also be synchronized during the growth of unicellular organisms. In the yeast Saccharomyces cerevisiae, mitosis is dependent on the prior growth of a daughter cell in the form of a bud.
C R, Bartholomew +4 more
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Gauchos and ochos: a Wee1-Cdk tango regulating mitotic entry
Cell Division, 2010 The kinase Wee1 has been recognized for a quarter century as a key inhibitor of Cyclin dependent kinase 1 (Cdk1) and mitotic entry in eukaryotes. Nonetheless, Wee1 regulation is not well understood and its large amino-terminal regulatory domain (NRD) has
Enders Greg H
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WEE1 inhibition sensitizes osteosarcoma to radiotherapy
BMC Cancer, 2011 Background The use of radiotherapy in osteosarcoma (OS) is controversial due to its radioresistance. OS patients currently treated with radiotherapy generally are inoperable, have painful skeletal metastases, refuse surgery or have undergone an ...
Helder Marco N +6 more
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ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
The Journal of Clinical Investigation, 2023 WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear.
Jie Li +16 more
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Smoking induces WEE1 expression to promote docetaxel resistance in esophageal adenocarcinoma
Molecular Therapy: Oncolytics, 2023 Esophageal adenocarcinoma (EAC) patients have poor clinical outcomes, with an overall 5-year survival rate of 20%. Smoking is a significant risk factor for EAC.
Md Obaidul Islam +13 more
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WEE1-mediated regulation of preMPF and MPF oscillations.
, 2020 (A) Approximated steady-state protein levels from studies by Ovejero et al. [8] using immunoblot analysis for CDK1T, CCNB1T, WEE1T and CDK1P Y15 (i.e. preMPF) in WEE1-expressing U2OS cells following release from synchronization in M phase.
Scott S. Terhune (8677500) +3 more
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Crosstalk among WEE1 Kinase, AKT, and GSK3 in Nav1.2 Channelosome Regulation. [PDF]
Int J Mol SciThe signaling complex around voltage-gated sodium (Nav) channels includes accessory proteins and kinases crucial for regulating neuronal firing. Previous studies showed that one such kinase, WEE1—critical to the cell cycle—selectively ...
Singh AK, Singh J, Goode NA, Laezza F.
europepmc +2 more sources
Arabidopsis WEE1 kinase controls cell cycle arrest in response to activation of the DNA integrity checkpoint [PDF]
, 2007 Upon the incidence of DNA stress, the ataxia telangiectasia-mutated (ATM) and Rad3-related (ATR) signaling kinases activate a transient cell cycle arrest that allows cells to repair DNA before proceeding into mitosis.
De Schutter, Kristof +24 more
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