Results 21 to 30 of about 499,052 (176)

Expression and prognostic value of the WEE1 kinase in gliomas

Journal of Neuro-Oncology, 2016
High-grade gliomas have an aggressive clinical course and new clinical biomarkers and therapeutic targets are highly needed. WEE1 is a regulator of the G2 checkpoint in glioblastoma (GBM) cells. Inhibition of this kinase has, in experimental glioma studies, been suggested to enhance sensitivity to irradiation and temozolomide. However, expression level
Music, Darija, Dahlrot, Rikke Hedegaard, Hermansen, Simon Kjær, Hjelmborg, Jacob v. B., de Stricker, Karin, Hansen, Steinbjørn, Kristensen, Bjarne Winther   +6 more
openaire   +3 more sources

WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2 [PDF]

Nature Communications
Inhibitors of the protein kinase WEE1 have emerged as promising agents for cancer therapy. In this study, we uncover synergistic interactions between WEE1 small-molecule inhibitors and defects in mRNA translation, mediated by activation of the integrated
Jordan C. J. Wilson, JiaYi Zhu, Vanesa Vinciauskaite, Eloise G. Lloyd, Simon Lam, Alexandra Hart, Chen Gang Goh, Fadia Bou-Dagher, Hlib Razumkov, Lena Kobel, Zacharias Kontarakis, John Fielden, Moritz F. Schlapansky, Joanna I. Loizou, Andreas Villunger, Jacob E. Corn, Giulia Biffi, Glenn R. Masson, Stefan J. Marciniak, Aldo S. Bader, Stephen P. Jackson   +20 more
doaj   +13 more sources

Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2 [PDF]

Journal of Biological Chemistry, 2023
James Moseley
exaly   +2 more sources

Chemically Induced Degradation of WEE1 Kinase for Difficult to Treat Diseases. [PDF]

ACS Med Chem Lett, 2020
Kargbo RB.
europepmc   +4 more sources

Enhancing direct cytotoxicity and response to immune checkpoint blockade following ionizing radiation with Wee1 kinase inhibition [PDF]

OncoImmunology, 2019
Clint Allen, Carter van Waes, Yvette Robbins   +2 more
exaly   +2 more sources

Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway

iScience, 2023
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius, Jan Benada, Olaf Nielsen, Erwin M. Schoof, Claus Storgaard Sørensen   +4 more
doaj   +1 more source

Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1

Cell Communication and Signaling, 2022
Background The treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease recurrence. The dysfunctional DNA damage repair mechanism plays an essential role not only in the initiation and ...
Fanting Zeng, Yuhang Peng, Yuefeng Qin, Jianming Wang, Guoyun Jiang, Wenli Feng, Ying Yuan   +6 more
doaj   +1 more source

Wee1 kinase as a target for cancer therapy [PDF]

Cell Cycle, 2013
Wee1, a protein kinase, regulates the G 2 checkpoint in response to DNA damage. Preclinical studies have elucidated the role of wee1 in DNA damage repair and the stabilization of replication forks, supporting the validity of wee1 inhibition as a viable therapeutic target in cancer.
Khanh, Do, James H, Doroshow, Shivaani, Kummar   +2 more
openaire   +2 more sources

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Haematologica, 2020
T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell progenitors.
Juncheng Hu, Tianci Wang, Jin Xu, Sanyun Wu, Liyuan Wang, Hexiu Su, Jue Jiang, Ming Yue, Jingchao Wang, Donghai Wang, Peng Li, Fuling Zhou, Yu Liu, Guoliang Qing, Hudan Liu   +14 more
doaj   +1 more source

Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. [PDF]

PLoS ONE, 2015
The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by Wee1 kinase in the presence of DNA damage.
Thomas Caspari, Victoria Hilditch
doaj   +1 more source