Results 11 to 20 of about 499,052 (176)
Targeting WEE1 Kinase for Breast Cancer Therapeutics: An Update [PDF]
International Journal of Molecular SciencesWEE1 kinase is a crucial cell cycle regulatory protein that controls the timing of mitotic entry. WEE1, via inhibition of Cyclin-dependent Kinase 1 (CDK1) and Cyclin-dependent Kinase 2 (CDK2), governs the G2-M checkpoint by inhibiting entry into mitosis.
Anthony Ashton, Richard Pestell
exaly +5 more sources
Development and Characterization of a Wee1 Kinase Degrader [PDF]
Cell Chemical Biology, 2020 The G1/S cell cycle checkpoint is frequently dysregulated in cancer, leaving cancer cells reliant on a functional G2/M checkpoint to prevent excessive DNA damage. Wee1 regulates the G2/M checkpoint by phosphorylating CDK1 at Tyr15 to prevent mitotic entry.
Nathanael Gray +2 more
exaly +6 more sources
Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells. [PDF]
PLoS ONE, 2014 Transforming growth factor-β1 (TGF-β1) potently inhibits human hepatocellular carcinoma (HCC) cell growth. Here we demonstrated that TGF-β1-induced apoptosis is mediated by decreased phosphorylation of cdc2 at Tyr15 accompanied by down-regulation of Wee1
Tomomi Kogiso +5 more
doaj +2 more sources
Casein Kinase 1δ-dependent Wee1 Protein Degradation [PDF]
Journal of Biological Chemistry, 2014 Eukaryotic mitotic entry is controlled by Cdk1, which is activated by the Cdc25 phosphatase and inhibited by Wee1 tyrosine kinase, a target of the ubiquitin proteasome pathway. Here we use a reporter of Wee1 degradation, K328M-Wee1-luciferase, to screen a kinase-directed chemical library. Hit profiling identified CK1δ-dependent Wee1 degradation.
Clara, Penas +12 more
openaire +3 more sources
Activation Domain-dependent Degradation of Somatic Wee1 Kinase [PDF]
Journal of Biological Chemistry, 2010 Cell cycle progression is dependent upon coordinate regulation of kinase and proteolytic pathways. Inhibitors of cell cycle transitions are degraded to allow progression into the subsequent cell cycle phase. For example, the tyrosine kinase and Cdk1 inhibitor Wee1 is degraded during G(2) and mitosis to allow mitotic progression.
Laura, Owens +8 more
openaire +3 more sources
Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival. [PDF]
PLoS ONE, 2013 Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a ...
Natalia Y Boynak +6 more
doaj +5 more sources
Regulation of Wee1 kinase in response to protein synthesis inhibition [PDF]
FEBS Letters, 2000 To investigate the mechanism coupling growth (protein synthesis) with cell division, we examined the relationship between the tyrosine kinase Wee1 that inhibits Cdc2‐Cdc13 mitosis‐inducing kinase by phosphorylating it, and protein synthesis inhibition in fission yeast.
Suda, Masako +4 more
openaire +3 more sources
Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer [PDF]
Clinical Cancer Research, 2017 Abstract Wee1 is a protein kinase that regulates the G2 checkpoint and prevents entry into mitosis in response to DNA damage. Cyclin-dependent kinases (CDK) are a family of 14 serine/threonine protein kinases that coordinate the progression through the cell cycle.
Geenen, Jill J., Schellens, Jan H M
core +8 more sources
Cell cycle regulation of a Xenopus Wee1-like kinase. [PDF]
Molecular Biology of the Cell, 1995 Using a polymerase chain reaction-based strategy, we have isolated a gene encoding a Wee1-like kinase from Xenopus eggs. The recombinant Xenopus Wee1 protein efficiently phosphorylates Cdc2 exclusively on Tyr-15 in a cyclin-dependent manner. The addition of exogenous Wee1 protein to Xenopus cell cycle extracts results in a dose-dependent delay of ...
Mueller, Paul R. +2 more
openaire +5 more sources
Investigation into the stability of WEE1 kinase in plants [PDF]
Phosphoregulation is essential for the control of cell division. In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of CDK by WEE1 kinase. WEE1 homologues have been identified in several species of higher plant, including Arabidopsis and tobacco.
Cook, Gemma S.
core +8 more sources