Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival. [PDF]
PLoS ONE, 2013 Regulation of eukaryotic cell cycle progression requires sequential activation and inactivation of cyclin-dependent kinases (CDKs). Activation of the cyclin B-cdc2 kinase complex is a pivotal step in mitotic initiation and the tyrosine kinase Wee1 is a ...
Natalia Y Boynak +6 more
doaj +1 more source
Enhancing Direct Cytotoxicity and Response to Immune Checkpoint Blockade Following Ionizing Radiation With Wee1 Kinase Inhibition [PDF]
OncoImmunology, 2019 Clint Allen +2 more
exaly +2 more sources
Temporal phosphoproteomics reveals WEE1-dependent control of 53BP1 pathway
iScience, 2023 Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints ...
Valdemaras Petrosius +4 more
doaj +1 more source
Cell Communication and Signaling, 2022 Background The treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease recurrence. The dysfunctional DNA damage repair mechanism plays an essential role not only in the initiation and ...
Fanting Zeng +6 more
doaj +1 more source
WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia
Haematologica, 2020 T-cell acute lymphoblastic leukemias (T-ALLs) are aggressive and heterogeneous hematologic tumors resulting from the malignant transformation of T-cell progenitors.
Juncheng Hu +14 more
doaj +1 more source
Targeting the DNA Damage Response for Cancer Therapy by Inhibiting the Kinase Wee1
Frontiers in Oncology, 2022 Cancer cells typically heavily rely on the G2/M checkpoint to survive endogenous and exogenous DNA damage, such as genotoxic stress due to genome instability or radiation and chemotherapy.
Amirali B. Bukhari +2 more
doaj +1 more source
Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe. [PDF]
PLoS ONE, 2015 The activity of Cdc2 (CDK1) kinase, which coordinates cell cycle progression and DNA break repair, is blocked upon its phosphorylation at tyrosine 15 (Y15) by Wee1 kinase in the presence of DNA damage.
Thomas Caspari, Victoria Hilditch
doaj +1 more source
YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
PLoS Biology, 2020 The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that transcriptomic m6A modification can be dynamic and the m6A reader protein YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) promotes mRNA decay ...
Qili Fei +4 more
doaj +1 more source
Construction and expression of Wee1 recombinant protein in Escherichia coli strain BL21 (DE3)
Jurnal Ilmu Dasar, 2023 Wee1 is a gene encoding for protein kinase that is located in the nucleus and it plays an essential role in determining the timing of mitosis. Overexpression of Wee1 in rice is resulting in increased plant size.
Ladefa Primana Oktapan +3 more
doaj +1 more source
CCNE1: A Cell Cycle Regulator That Influences Tumor Progression. [PDF]
Cancer MedABSTRACTCyclin E1 (CCNE1), a pivotal member of the cyclin family, governs the G1/S phase transition of the cell cycle by binding to and activating cyclin‐dependent kinase 2 (CDK2), thereby initiating DNA replication and driving S‐phase entry. In a broad spectrum of human malignancies—including breast, ovarian, gastric, and non‐small cell lung cancers ...
Yan L +6 more
europepmc +2 more sources