Results 41 to 50 of about 9,531 (127)
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2
Nature CommunicationsInhibitors of the protein kinase WEE1 have emerged as promising agents for cancer therapy. In this study, we uncover synergistic interactions between WEE1 small-molecule inhibitors and defects in mRNA translation, mediated by activation of the integrated
Jordan C. J. Wilson +20 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, Volume 20, Issue 10, Page 2490-2509, October 2026.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Stable Pom1 clusters form a glucose-modulated concentration gradient that regulates mitotic entry
eLife, 2019 Control of cell size requires molecular size sensors that are coupled to the cell cycle. Rod-shaped fission yeast cells divide at a threshold size partly due to Cdr2 kinase, which forms nodes at the medial cell cortex where it inhibits the Cdk1-inhibitor
Corey A H Allard +2 more
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WEE1 as a checkpoint regulator and therapeutic vulnerability: From biology to clinical development
SAGE Open MedicineWEE1 is a critical cell-cycle checkpoint kinase that inhibits cyclin-dependent kinase activity via phosphorylation, coordinating DNA replication, repair, and mitotic entry.
Huiting Jia, Menghua Dong
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Thoracic Cancer, 2023 Background DNA damage repair is a crucial mechanism highly related to therapy resistance for various therapeutic strategies. Our previous results have shown that the degree of drug resistance in small‐cell lung cancer (SCLC) cell lines was proportional ...
Xiaoliang Zhao, Xiaohua Wen, Bin Liu
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Targeting the DNA Damage Response in Cancer
MedComm, Volume 7, Issue 10, October 2026.Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao +4 more
wiley +1 more source
International Journal of Biological Sciences, 2006 Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry.
Yohei Tominaga, Cuiling Li, Rui-Hong Wang, Chu-Xia Deng
doaj
The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation
Cell Reports, 2020 Summary: Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis.
Sarah Lockhead +7 more
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Journal of Integrative Plant Biology, Volume 68, Issue 10, Page 3644-3669, October 2026.The tomato mars1/rough mutant displays enhanced root regeneration and rough fruits due to ectopic cell proliferation. The causal gene encodes a lysine‐specific histone demethylase that normally maintains gene silencing. Its loss alters histone methylation, upregulating several genes, including those B‐type cyclins involved in tissue‐specific cellular ...
Eduardo Larriba +14 more
wiley +1 more source
Haematologica, 2014 Novel combinations targeting new molecular vulnerabilities are needed to improve the outcome of patients with acute myeloid leukemia. We recently identified WEE1 kinase as a novel target in leukemias.
Leena Chaudhuri +13 more
doaj +1 more source