Results 41 to 50 of about 499,052 (176)

Cloning, transformation and expression of cell cycle-associated protein kinase OsWee1 in indica rice (Oryza sativa L.)

Journal of Genetic Engineering and Biotechnology, 2018
The development process of seed in plants is a cycle of cells which occur gradually and regularly. One of the genes involved in controling this stage is the Wee1 gene.
Frengky H.H. Prasetyo, Bambang Sugiharto, Netty Ermawati   +2 more
doaj   +1 more source

Combined evaluation of both WEE1 and phosphorylated cyclin dependent kinase 1 expressions in oral squamous cell carcinomas predicts cancer recurrence and progression

Journal of Dental Sciences, 2022
Background/purpose: WEE1 is a mitotic inhibitor at G2 checkpoint of the cell cycle that negatively regulates cyclin-dependent kinase 1 (CDK1) through inhibitory phosphorylation.
Yu-Hsueh Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Yi-Ping Wang   +3 more
doaj   +1 more source

Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas. [PDF]

Int J Cancer
AbstractFilamin A (FLNA) is poorly expressed in adrenocortical carcinomas (ACC) compared to adenomas (ACA). Its presence is associated to a less aggressive tumour behaviour, potentially due to its role in negatively regulating IGF1R signalling. Upregulation of G2/M Wee1 kinase was shown in FLNA‐deficient mouse neural progenitor cells, and it has been ...
Esposito E, Marra G, Catalano R, Maioli S, Nozza E, Barbieri AM, Hantel C, Di Dalmazi G, Sigala S, Geginat J, Cassinotti E, Baldari L, Palmieri S, Mangone A, Berruti A, Ferrante E, Mantovani G, Peverelli E.   +17 more
europepmc   +4 more sources

Increased HDAC Activity and c-MYC Expression Mediate Acquired Resistance to WEE1 Inhibition in Acute Leukemia

Frontiers in Oncology, 2020
WEE1 is a cell cycle and DNA damage response kinase that is emerging as a therapeutic target for cancer. AZD1775 is a small molecule inhibitor of WEE1, currently in early phase clinical trials as a single agent and in combination with more conventional ...
Tamara B. Garcia, Rizvan C. Uluisik, Annemie A. van Linden, Kenneth L. Jones, Sujatha Venkataraman, Rajeev Vibhakar, Christopher C. Porter   +6 more
doaj   +1 more source

WEE1 kinase in cancer: Molecular mechanisms and inhibitor insights. [PDF]

EXCLI J
EXCLI Journal; 25:Doc1186; ISSN 1611 ...
Kumar A, Paudel KR, Kaur R, Bhatia R.
europepmc   +2 more sources

Perturbation of cytokinin and ethylene-signalling pathways explain the strong rooting phenotype exhibited by Arabidopsis expressing the Schizosaccharomyces pombe mitotic inducer, cdc25 [PDF]

, 2012
Background Entry into mitosis is regulated by cyclin dependent kinases that in turn are phosphoregulated. In most eukaryotes, phosphoregulation is through WEE1 kinase and CDC25 phosphatase.
Marchbank, A., Doonan, John, DOONAN J., Prinsen, Els, Angela Marchbank, Rogers Hilary J, Sherong Li, MARCHBANK A., Bruno, Leonardo, PRINSEN E., Li, Sherong, Spadafora Natasha D, Rogers HJ, FRANCIS D., Li Sherong, Doonan J, Diego Albani, Francis D, Parfitt, David, Nieuwland Jeroen, John Doonan, Bitonti MB, Buchanan-Wollaston, Vicky, Natasha Spadafora, Hilary Rogers, Spadafora, Natasha, Rogers, H.J., Vaughn, R., Li S, Parfitt, D., Albani Diego, Bruno Leonardo, Marchbank A, Vaughan R, Nieuwland, Jeroen, BITONTI M. B., Bruno L, Herbert RJ, Spadafora, N.D., Robert Herbert, Marchbank, Angela Maureen, HERBERT R., Li, S., Francis, Dennis, Rhys Vaughan, Albani, Diego Maria, Dennis Francis, Li S., Prinsen Els, Rogers, Hilary J., Leonardo Bruno, Spadafora, Natasha D., SPADAFORA D., PARFITT D., Herbert Robert J, Prinsen E, Vaughan, Rhys, David Parfitt, Jeroen Nieuwland, Francis Dennis, Bruno, L., Herbert, Rob, Bitonti, M.B., Prinsen, E., Maria Beatrice Bitonti, Rogers, Hilary Joan, Els Prinsen, Albani, Diego, Vicky Buchanan-Wollaston, VAUGHAN R., Francis, D. (Dennis), Buchanan-Wollaston Vicky, Spadafora ND, Rogers, Hilary, Herbert, Robert, ROGERS H. R., Nieuwland, J., Albani, D., Parfitt David, Doonan John, Doonan, J., ALBANI D., Buchanan Wollaston V, Buchanan-Wollaston, V., Bitonti, Maria Beatrice, Parfitt D, Nieuwland J, BRUNO L., Marchbank Angela, WOLLASTON B., Bitonti Maria, Francis, D., Marchbank, Angela, Vaughan Rhys, NIEUWLAND J., Bitonti, B.M., Sherong, L., et al.   +97 more
core   +1 more source

WEE1 kinase inhibition triggers severe chromosome pulverization in aneuploid cells

, 2023
Aneuploidy, a hallmark of cancer, is a prominent feature associated with poor prognosis in breast cancer. Here, we screened a panel of cell cycle kinase inhibitors to identify novel targets for highly aneuploid breast cancers.
Haykal, Maria, M, Nahmias, Clara, Rodrigues-Ferreira, Sylvie   +2 more
core   +1 more source

Inhibition of WEE1 kinase and cell cycle checkpoint activation sensitizes head and neck cancers to natural killer cell therapies

Journal for ImmunoTherapy of Cancer, 2018
Background Natural killer (NK) cells recognize and lyse target tumor cells in an MHC-unrestricted fashion and complement antigen- and MHC-restricted killing by T-lymphocytes.
Jay Friedman, Megan Morisada, Lillian Sun, Ellen C. Moore, Michelle Padget, James W. Hodge, Jeffrey Schlom, Sofia R. Gameiro, Clint T. Allen   +8 more
doaj   +1 more source

Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor

Molecular Cancer, 2009
Background Wee1 is a tyrosine kinase regulating S-G2 cell cycle transition through the inactivating phosphorylation of CDC2. The inhibition of Wee1 kinase by a selective small molecule inhibitor significantly enhances the anti-tumor efficacy of DNA ...
Mizuarai Shinji, Yamanaka Kazunori, Itadani Hiraku, Arai Tsuyoshi, Nishibata Toshihide, Hirai Hiroshi, Kotani Hidehito   +6 more
doaj   +1 more source

Identification of Aurora Kinase B and Wee1-Like Protein Kinase as Downstream Targets of V600EB-RAF in Melanoma [PDF]

, 2013
BRAF is the most mutated gene in melanoma, with approximately 50% of patients containing V600E mutant protein. V600EB-RAF can be targeted using pharmacological agents, but resistance develops in patients by activating other proteins in the signaling ...
Madhunapantula, SubbaRao V., Gowda, Raghavendra, Robertson, Gavin P., Sharma, Arati, Berg, Arthur, Neves, Rogerio I.   +5 more
core   +1 more source