Results 71 to 80 of about 1,296,830 (230)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Drug Design, Development and Therapy, 2022 Jia Li,1,* Xiao Wang,1,* Shining Xun,2,* Qiuting Guo,3 Yao Wang,1 Yanzuo Jia,1 Wenfei Wang,1 Yujiao Wang,1 Taotao Li,1 Tiantian Tang,1 Junbo Zou,1 Mei Wang,1 Ming Yang,4 Fang Wang,4 Xiaofei Zhang,1,4 Changli Wang1 1Department of Pharmaceutics,
Li J +15 more
doaj
Mathematics, 2020 In this paper we establish a new half-discrete Hilbert-type inequality involving the variable upper limit integral and partial sums. As applications, an inequality obtained from the special case of the half-discrete Hilbert-type inequality is further ...
Jianquan Liao, Shanhe Wu, Bicheng Yang
doaj +1 more source
A weighted transplantation theorem for Jacobi coefficients [PDF]
Journal of Approximation Theory, 2019 We present a transplantation theorem for Jacobi coefficients in weighted spaces. In fact, by using a discrete vector-valued local Calderón-Zygmund theory, which has recently been furnished, we prove the boundedness of transplantation operators from $\ell^p(\mathbb{N},w)$ into itself, where $w$ is a weight in the discrete Muckenhoupt class $A_{p ...
Arenas, Alberto +2 more
openaire +5 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
On a New Extended Hardy–Hilbert’s Inequality with Parameters
Mathematics, 2020 In this paper, by introducing parameters and weight functions, with the help of the Euler−Maclaurin summation formula, we establish the extension of Hardy−Hilbert’s inequality and its equivalent forms.
Bicheng Yang, Shanhe Wu, Jianquan Liao
doaj +1 more source
Length-weight relationships of marine fishes from the central Brazilian coast [PDF]
, 2004 Parameters of the length-weight relationship are presented for 85 fish species from the marine and estuarine regions of the central Brazilian coast (latitude 13° to 23° S). Three different methods were used. A non-linear iterative process using the quasi-
Braga, A.C., Costa, P.A.S., Frota, L.O.
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
An extension of a multidimensional Hilbert-type inequality
Journal of Inequalities and Applications, 2017 In this paper, by the use of weight coefficients, the transfer formula and the technique of real analysis, a new multidimensional Hilbert-type inequality with multi-parameters and a best possible constant factor is given, which is an extension of some ...
Jianhua Zhong, Bicheng Yang
doaj +1 more source
Strain arrestor plate for mounting rigid insulating tiles [PDF]
, 1974 Plate is made of material having coefficient to thermal expansion similar to that of insulating material. Although plate may be formed from appropriate alloy, it has been found that a combination of graphite fibers in epoxy resin is satisfactory and much
Kural, M. H.
core +1 more source