Results 51 to 60 of about 166,488 (254)

An ERA5‐Based Model for Estimating Tropospheric Delay and Weighted Mean Temperature Over China With Improved Spatiotemporal Resolutions

Earth and Space Science, 2019
Tropospheric delay is an important error source in Global Navigation Satellite System (GNSS) positioning and can also be used in water vapor monitoring.
Zhangyu Sun, Bao Zhang, Yibin Yao
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Weighting alternative for water stable isotopes: Statical comparison between station- and firn/ice-records

Polish Polar Research, 2017
It is generally accepted that ice cores archive amount-weighted water stable isotope signals. In order to achieve an improved understanding of the nature of water stable isotope signals stored in ice cores annual δ18O and δ2H averages (i.e.
Hatvani István Gábor, Kern Zoltán
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Precipitable Water Vapor Converted from GNSS-ZTD and ERA5 Datasets for the Monitoring of Tropical Cyclones

IEEE Access, 2020
Tropical cyclones (TCs) are intense rotating storm systems, characterized by strong winds, heavy humidity and storm surges, and usually cause an abnormal increase in regional water vapor during the period of their occurrence.
Qimin He, Zhen Shen, Moufeng Wan, Longjiang Li   +3 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Seasonal Multifactor Modelling of Weighted-Mean Temperature for Ground-Based GNSS Meteorology in Hunan, China

Advances in Meteorology, 2017
In this study, radiosonde observations during the period of 2012-2013 from three stations in the Hunan region, China, were used to establish regional Tm models (RTMs) that are a fitting function of multiple meteorological factors (Ts, Es, and Ps).
Li Li, Suqin Wu, Xiaoming Wang, Ying Tian, Changyong He, Kefei Zhang   +5 more
doaj   +1 more source

Experimental calculation of the mean temperature of flat plate thermal solar collectors

Results in Engineering, 2020
The mean temperature of flat plate solar thermal collectors (FPSTC) is used to calculate collector efficiency and other related parameters. This temperature is a key aspect for the determination of thermal losses or the inertial behavior of a collector ...
Manuel Seco-Nicolás, Mariano Alarcón García, Juan Pedro Luna-Abad   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Augmentation Method for Weighted Mean Temperature and Precipitable Water Vapor Based on the Refined Air Temperature at 2 m above the Surface of Land from ERA5

Remote Sensing
Due to the difference in the quality of the global assimilation data and the ability to reproduce the real conditions of the atmosphere, the hourly atmospheric temperature at 2 m above the land surface from ERA5 cannot be used with complete confidence ...
Caiya Yue, Hu Wang, Changhui Xu
doaj   +1 more source