Results 61 to 70 of about 66,491 (306)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Functional-Coefficient Spatial Durbin Models with Nonparametric Spatial Weights: An Application to Economic Growth

Econometrics, 2016
This paper considers a functional-coefficient spatial Durbin model with nonparametric spatial weights. Applying the series approximation method, we estimate the unknown functional coefficients and spatial weighting functions via a nonparametric two-stage
Mustafa Koroglu, Yiguo Sun
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

FCS-MPC Based on Dimension Unification Cost Function

Energies
Finite Control Set Model Predictive Control (FCS-MPC) has the ability to achieve multi-objective optimization, but there are still many challenges. The key to realizing multi-objective optimization in FCS-MPC lies in the design of the cost function ...
Jinyang Han, Hao Yuan, Weichao Li, Liang Zhou, Chen Deng, Ming Yan   +5 more
doaj   +1 more source

Decision Optimization of Machine Sets Taking Into Consideration Logical Tree Minimization of Design Guidelines

International Journal of Applied Mechanics and Engineering, 2014
The method of minimization of complex partial multi-valued logical functions determines the degree of importance of construction and exploitation parameters playing the role of logical decision variables. Logical functions are taken into consideration in
A. Deptuła, M.A. Partyka
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Coefficients of half-integral weight modular forms

Journal of Number Theory, 2003
Inspired by Kolyvagin's celebrated work on the Birch and Swinnerton-Dyer Conjecture and works of Waldspurger, Kohnen and Zagier relating the Fourier coefficients of half-integral weight Hecke eigenforms to values of modular \(L\)-functions (there have been a number of works on the indivisibility of the coefficients of half-integral weight modular forms)
Bruinier, Jan H., Ono, Ken
openaire   +1 more source

Weighting coefficients for walks of length one to three () for the PI, GI, Blogs, Patent, and Facebook networks.

, 2012
Weighting coefficients for walks of length one to three () for the PI, GI, Blogs, Patent, and Facebook networks.
Sara Mostafavi (51056), Anna Goldenberg (106257), Quaid Morris (51067)   +2 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Model averaged coefficients, standard errors and weighting for each variable included in the 90% confidence set of models.

, 2013
Model averaged coefficients, standard errors and weighting for each variable included in the 90% confidence set of models.
Sarah Legge (416319), Anja Skroblin (416318)   +1 more
core   +1 more source