Results 81 to 90 of about 66,491 (306)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Effect of Weighting Schemes on Weighted Kappa Coefficients in Multi-Rater Agreement Studies with Ordinal Categories

open access: yes
Weighted kappa and kappa-like coefficients are used for the calculation of inter-rater agreement in cases where raters classify objects into ordinal categories. Weighted kappa coefficients are extended for use in studies with multiple raters.
Yilmaz, Ayfer Ezgi
core   +1 more source

Weighting coefficients for the linear combination LCTXT1, obtained after averaging the parameters over 1000 runs of PSO.

open access: yes, 2016
Weighting coefficients for the linear combination LCTXT1, obtained after averaging the parameters over 1000 runs of PSO.
Francesca Gasparini (2851703)   +3 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Calibrated weighting coefficients for the SD-CLUES-S model in the study area (significance of all variables at p<0.01).

open access: yes, 2017
Calibrated weighting coefficients for the SD-CLUES-S model in the study area (significance of all variables at ...
Jiejun Huang (3775717)   +2 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

On recurrence coefficients for rapidly decreasing exponential weights

open access: yesJournal of Approximation Theory, 2007
The main problem under consideration in the present paper is the relationship between the rate of convergence of the recurrence coefficients, and the rate of decay of the exponential weight at the endpoints of the orthogonality interval \((a,b)\) (finite or infinite).
Eli Levin, Doron S. Lubinsky
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Reliability-coefficients [15,22] for categories and pictures regarding the two scales hope for success and fear of failure without weighting categories.

open access: yes, 2016
Reliability-coefficients [15,22] for categories and pictures regarding the two scales hope for success and fear of failure without weighting categories.
Ludwig Kreuzpointner (480303)   +1 more
core   +1 more source

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