Results 71 to 80 of about 66,491 (306)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

COMPLEX QUALITY CRITERION OF CONTROL OF THE INTELLECTUAL SERVICES PROVISION IN NGN

Holodilʹnaâ Tehnika i Tehnologiâ, 2016
The paper is dedicated to intellectual services provision control quality comparison by the intellectual superstructures with centralized and decentralized control principles in NGN. The necessity of three parties interests consideration, namely: service
N. O. Kniazieva, S. V. Shestopalov
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The Localization Procedures of the Vector of Weighting Coefficients for Fuzzy Models of Choice [PDF]

, 2008
The author analyzes the localization procedures of the vector of weighting coefficients which are based on presenting the function of value by additive reduction adapted to fuzzy models of ...
Prisyazhnyuk, Elena
core  

Optimum-Weighted RLS Channel Estimation for Rapid Fading MIMO Channels [PDF]

, 2008
This paper investigates on an accurate channel estimation scheme for fast fading channels in multiple-input multiple-output (MIMO) mobile communications.
Koike-Akino, Toshiaki
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Urban sustainability assessment: An analysis of how weighting and aggregating coefficient system was used in the development of SUCCEED assessment tool for developing countries

Frontiers in Built Environment
The development of a weighting and aggregating coefficient system used in urban sustainability assessment tools is a process that needs well-defined procedures using a series of steps, methodology, and a systematic approach in its development.
Job Momoh, Olubisi Ige, Rafiu Seidu, Lucy Ogbenjuwa, Bert Young, Yusuf Ibraheem   +5 more
doaj   +1 more source

PRIORITY BASIC PROPERTIES GEOIMAGES

InterCarto. InterGIS, 2014
As a result of the collective expert evaluation prioritized geoimages basic properties based on their weighting factors. Results of examinations checked for coherence, while considered a factor of scientific expertise.
T. Kurach, R. Oliynyk
doaj   +1 more source

A Novel Approach for Data Feature Weighting Using Correlation Coefficients and Min–Max Normalization

, 2023
In the realm of data analysis and machine learning, achieving an optimal balance of feature importance, known as feature weighting, plays a pivotal role, especially when considering the nuanced interplay between the symmetry of data distribution and the ...
Zalinda Othman, Azuraliza Abu Bakar, Mohammed Shantal   +2 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source