Results 121 to 130 of about 2,574,835 (312)

Alterations to nuclear architecture and genome behavior in senescent cells. [PDF]

, 2007
The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions.
Abney J.R., Agrelo R., Barboro P., Becker P.B., Bemiller P.M., Benn P.A., Berezney R., Bowman P.D., Bridger J.M., Bridger J.M., C. S. CLEMENTS, Campisi J., Chaly N., Chang K.S., Cremer T., de Lange T., Dell'Orco R.T., Dijkwel P.A., Ferbeyre G., Filesi I., Fisher A.G., Fleischer S., Goldman R.D., Gruenbaum Y., Haque F., Hernandez-Verdun D., Holliday R., Hozak P., I. R. KILL, I. S. MEHTA, J. M. BRIDGER, Kill I.R., Kreth G., Lezhava T., Li Y., M. FIGGITT, Mallette F.A., Manuelidis L., Mazin A.L., Mitsui Y., Mukherjee A.B., Nickerson J., Okabe J., Padiath Q.S., Pawelec G., Petrova N.V., Schardin M., Schulz L., Smilenov L.B., Strouboulis J., Tanabe H., van Driel R., Wang G.S.   +52 more
core   +1 more source

Liver aging and pseudocapillarization in a Werner syndrome mouse model.

The journals of gerontology. Series A, Biological sciences and medical sciences, 2014
Werner syndrome is a progeric syndrome characterized by premature atherosclerosis, diabetes, cancer, and death in humans. The knockout mouse model created by deletion of the RecQ helicase domain of the mouse Wrn homologue gene (Wrn(∆hel/∆hel)) is of ...
V. Cogger, D. Svistounov, A. Warren, S. Zykova, Richard G Melvin, Samantha M. Solon-Biet, Jennifer N. O’Reilly, A. Mcmahon, J. Ballard, R. de Cabo, D. L. Le Couteur, M. Lebel   +11 more
semanticscholar   +1 more source

A rare case of Herlyn-Werner-Wunderlich syndrome-with pregnancy

The Egyptian Journal of Radiology and Nuclear Medicine, 2016
Herlyn-Werner-Wunderlich syndrome also known as uterus didelphys with obstructing hemivaginal septum and ipsilateral renal agenesis (OHVIRA) is a very rare syndrome with only a few case reported.
Vikas Deswal, Nauratmal Kumawat, Sunita Purohit, Rajendra Jat   +3 more
doaj   +1 more source

The Heli-CASE of the Missing WRN Gene [PDF]

Werner Syndrome is an autosomal recessive disease characterized by genomic instability, accelerated telomere shortening, and premature aging. Also, Werner Syndrome patients experience increased cancer rates, believed to be directly related to the lack of
Jeziorny, Lisa, McCurdy, Lindsey, Michael, Katie, Riddle, Jennifer, Silvers, Kim   +4 more
core   +1 more source

False consensus beliefs and populist attitudes

Political Psychology, EarlyView.
Abstract A well‐established finding from social psychology is that people tend to hold “false consensus beliefs,” that is, they regularly overestimate how many others agree with their own opinions. However, the consequences of such beliefs for citizens' assessment of democratic legitimacy are still largely unexplored.
Nils D. Steiner, Claudia Landwehr, Philipp Harms   +2 more
wiley   +1 more source

Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks

Aging, 2014
WRN protein, defective in Werner syndrome (WS), a human segmental progeria, is a target of serine/threonine kinases involved in sensing DNA damage. DNA-PK phosphorylates WRN in response to DNA double strand breaks (DSBs).
Rika Kusumoto‐Matsuo, D. Ghosh, P. Karmakar, A. May, D. Ramsden, V. Bohr   +5 more
semanticscholar   +1 more source

Correspondence to: Clinico‐sero‐pathological characteristics of anti‐Ha antisynthetase syndrome

Brain Pathology, EarlyView.
Marie‐Therese Holzer, Robert Biesen, Sarah Tansley, Carsten Dittmayer, Werner Stenzel, Udo Schneider   +5 more
wiley   +1 more source

Lateral Tarsorrhaphy and Fixation on the Orbital Ligament to Correct Macroblepharon in Dogs: 77 Palpebral Fissures

Veterinary Ophthalmology, Volume 28, Issue 2, Page 448-456, March 2025.
ABSTRACT Purpose To describe a surgical method for correcting lower lid entropion, lateral canthal entropion, and macroblepharon. Methods Lid margins were incised at a 45° angle, and lateral lid margins and a rhomboid shaped piece of skin were resected based on the degree of macroblepharon.
Maximilian Werner‐Tutschku, Barbara Nell   +1 more
wiley   +1 more source

Tall Stature and Scoliosis Associated With a Novel Homozygous Loss‐of‐Function Missense Variant in NPR3

American Journal of Medical Genetics Part A, Volume 197, Issue 8, August 2025.
ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt, Chantal Janelle, Valancy Miranda, Ghalib Bardai, Frank Rauch   +4 more
wiley   +1 more source

WRN regulates pathway choice between classical and alternative non-homologous end joining

Nature Communications, 2016
Werner Syndrome is an accelerated aging disorder marked by genome instability, large deletions and telomere fusions, hallmarks of aberrant DNA repair.
Raghavendra A. Shamanna, Huiming Lu, Jessica K. de Freitas, Jane Tian, Deborah L. Croteau, Vilhelm A. Bohr   +5 more
doaj   +1 more source