Nature Communications, 2016 Werner syndrome is a progeroid disease characterised by genetic instability due to mutations to the WRN helicase/exonuclease. Here the authors define a novel Ku binding motif (KBM) and show that two such motifs facilitate the involvement of WRN in DNA ...
Gabrielle J. Grundy +7 more
doaj +1 more source
Association of Impaired Phosphatidylinositol 3-Kinase Activity in GLUT1-Containing Vesicles with Malinsertion of Glucose Transporters into the Plasma Membrane of Fibroblasts from a Patient with Severe Insulin Resistance and Clinical Features of Werner Syndrome1 [PDF]
, 2000 Christiana Kausch +11 more
openalex +1 more source
New Phytologist, Volume 247, Issue 1, Page 369-387, July 2025.Summary The butterfly‐shaped keel flower is a highly successful floral form in angiosperms. These flowers steer the mechanical interaction with bees and thus are hypothesized to accelerate pollinator‐driven diversification. The exceptionally labile evolution of keel flowers in Papilionoideae (Fabaceae) provides a suitable system to test this hypothesis.
Liming Cai +10 more
wiley +1 more source
The Herlyn-Werner-Wunderlich (HWW) syndrome – A case report with radiological review
Radiology Case Reports, 2022 Herlyn-Werner-Wunderlich (HWW) syndrome is a rare congenital anomaly of female urogenital tract involving combined mullerian duct anomalies and mesonephric duct malformation characterized by uterus didelphys, obstructed hemi-vagina and ipsilateral renal ...
Abdul Malik Hayat, MD, MPH +3 more
doaj
Telomere repeat DNA forms a large non-covalent complex with unique cohesive properties which is dissociated by Werner syndrome DNA helicase in the presence of replication protein A [PDF]
, 2000 Itaru Ohsugi
openalex +1 more source
A novel ZRS variant causes preaxial polydactyly type I by increased sonic hedgehog expression in the developing limb bud. [PDF]
, 2020 PurposePreaxial polydactyly (PPD) is a common congenital hand malformation classified into four subtypes (PPD I-IV). Variants in the zone of polarizing activity regulatory sequence (ZRS) within intron 5 of the LMBR1 gene are linked to most PPD types ...
Ahituv, Nadav +19 more
core
BMC Ophthalmology, 2014 BackgroundTo present our findings in a case of Werner syndrome with refractory cystoid macular edema (CME) and to determine the expression and the distribution of WRN proteins in human retinas.Case presentationA 35-year-old man with Werner syndrome who ...
T. Oshitari +8 more
semanticscholar +1 more source
Evidence for a Replication Function of Ffa-1, theXenopusOrthologue of Werner Syndrome Protein [PDF]
, 2001 Chin‐Yi Chen, Jeanine Graham, Hong Yan
openalex +1 more source
Werner's syndrome and malignancy
Acta Dermato-Venereologica, 1976 Ten per cent of all patients with Werner's syndrome develop some form of malignant disease, half of them sarcomas. A case of Werner's syndrome is reported in which the patient had a malignant fibroxanthoma of the thigh followed by a papillary cystadenocarcinoma of the ovaries. A brother with clinical signs of Werner's syndrome died of acute leukaemia.
openaire +2 more sources
Chinese Seed Trait Database: a curated resource for diaspore traits in the Chinese flora
New Phytologist, EarlyView.
Hao‐Yu Wang +2 more
wiley +1 more source