Results 21 to 30 of about 2,574,835 (312)
Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]
, 2015 Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley +10 more
core +7 more sources
Constitutional Oncogenetics, 2020 A rare, autosomal recessive syndrome caused by mutations in the WRN gene. It is characterized by the appearance of accelerated aging following puberty. It is associated with the development of diabetes mellitus, atherosclerosis, cataracts, and cancer.
Dongyou Liu
semanticscholar +1 more source
Андрология и генитальная хирургия, 2021 Herlyn–Werner–Wunderlich syndrome (OHVIRA syndrome) is a combined malformation of the genitourinary systeme, characterized by various combinations of uterus dydelphys with unilateral obstructed (or blind) hemivagina and ipsilateral renal agenesis.
K. Kh. Alieva +4 more
doaj +1 more source
Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome
Pharmaceuticals, 2010 Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process.
Mark C. Bagley +4 more
doaj +1 more source
Treatment of Virgin OHVIRA Syndrome with Haematometrocolpos by Complete Incision of Vaginal Septum without Hymenotomy [PDF]
Journal of Clinical and Diagnostic Research, 2015 Mullerian malformations result from defective fusion of the Mullerian ducts during development of the female reproductive system and have an incidence of 2-3%.
Niyazi Tug +4 more
doaj +1 more source
Hereditary syndromes with signs of premature aging [PDF]
Остеопороз и остеопатии, 2020 Aging is a multi-factor biological process that inevitably affects everyone. Degenerative processes, starting at the cellular and molecular levels, gradually influence the change in the functional capabilities of all organs and systems.
Olga O. Golounina +2 more
doaj +1 more source
Herlyn-Werner-Wunderlich syndrome : a rare genitourinary anomaly in females : a series of four cases [PDF]
, 2018 We present case series of four patients with an important syndrome known as Herlyn-Werner-Wunderlich syndrome. Herlyn-Werner-Wunderlich syndrome is a rare congenital anomaly characterised by uterus didelphys with blind hemivagina and ipsilateral renal ...
Ilyas, Mohd +2 more
core +1 more source
Werner Syndrome Protein and DNA Replication. [PDF]
Int J Mol Sci, 2018 Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development of aging features. Individuals with WS also have a greater predisposition to rare cancers that are mesenchymal in origin.
Mukherjee S +5 more
europepmc +2 more sources
BMC Women's Health, 2018 Background Herlyn-Werner-Wunderlich syndrome is a very rare congenital genitourinary anomaly characterized by uterus didelphys, blind hemivagina and ipsilateral renal agenesis. Case presentation Authors present a case of Herlyn-Werner-Wunderlich syndrome
Hidayatullah Hamidi, Nilab Haidary
doaj +1 more source
Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms [PDF]
, 2003 Werner-syndrome fibroblasts have a reduced in vitro life span before entering replicative senescence. Although this has been thought to be causal in the accelerated ageing of this disease, controversy remains as to whether Werner syndrome is showing the ...
Davis, T. +9 more
core +2 more sources