Results 31 to 40 of about 95,890 (268)

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome

Pharmaceuticals, 2010
Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process.
Mark C. Bagley, Terence Davis, Paola G. S. Murziani, Caroline S. Widdowson, David Kipling   +4 more
doaj   +1 more source

Treatment of Virgin OHVIRA Syndrome with Haematometrocolpos by Complete Incision of Vaginal Septum without Hymenotomy [PDF]

Journal of Clinical and Diagnostic Research, 2015
Mullerian malformations result from defective fusion of the Mullerian ducts during development of the female reproductive system and have an incidence of 2-3%.
Niyazi Tug, Mehmet Akif Sargin, Ayhan Çelik, Turgut Alp, Ilter Yenidede   +4 more
doaj   +1 more source

Herlyn-Werner-Wunderlich syndrome : a rare genitourinary anomaly in females : a series of four cases [PDF]

, 2018
We present case series of four patients with an important syndrome known as Herlyn-Werner-Wunderlich syndrome. Herlyn-Werner-Wunderlich syndrome is a rare congenital anomaly characterised by uterus didelphys with blind hemivagina and ipsilateral renal ...
Ilyas, Mohd, Khan, Insha, Saldanha, Cimona L.   +2 more
core   +1 more source

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

Clinical Epigenetics, 2017
Background Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although it is well established that autosomal recessive mutations in the WRN gene is responsible for Werner syndrome, the molecular alterations that ...
T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani, F. Bondanini   +11 more
doaj   +1 more source

Hereditary syndromes with signs of premature aging [PDF]

Остеопороз и остеопатии, 2020
Aging is a multi-factor biological process that inevitably affects everyone. Degenerative processes, starting at the cellular and molecular levels, gradually influence the change in the functional capabilities of all organs and systems.
Olga O. Golounina, Valentin V. Fadeev, Zhanna E. Belaya   +2 more
doaj   +1 more source

Accelerated epigenetic aging in Werner syndrome. [PDF]

, 2017
Individuals suffering from Werner syndrome (WS) exhibit many clinical signs of accelerated aging. While the underlying constitutional mutation leads to accelerated rates of DNA damage, it is not yet known whether WS is also associated with an increased ...
Flunkert, Julia, Haaf, Thomas, Horvath, Steve, Maierhofer, Anna, Martin, George M, Oshima, Junko   +5 more
core   +1 more source

BLM and RMI1 alleviate RPA inhibition of topoIIIα decatenase activity [PDF]

, 2012
RPA is a single-stranded DNA binding protein that physically associates with the BLM complex. RPA stimulates BLM helicase activity as well as the double Holliday junction dissolution activity of the BLM-topoisomerase IIIα complex.
A Bochkarev, A Machwe, AR Meetei, C Iftode, CF Chen, Csanad Z. Bachrati, CZ Bachrati, D Sikder, D Xu, Grant W. Brown, H Goulaouic, Ian D. Hickson, ID Hickson, J Yang, J Yin, Jay Yang, JJ Champoux, JL Plank, JL Plank, K Kirkegaard, KM Doherty, L Wu, L Wu, MP Fairman, MS Wold, MS Wold, NA Desai, NA Ellis, P Cejka, P Mohaghegh, PL Garcia, RM Brosh Jr, RS Chaganti, S Raynard, S Raynard, S Sharma, Sergey Korolev, T Wechsler, Y Liu, Y Zou   +39 more
core   +9 more sources

Human RecQ Helicases in DNA Double-Strand Break Repair

Frontiers in Cell and Developmental Biology, 2021
RecQ DNA helicases are a conserved protein family found in bacteria, fungus, plants, and animals. These helicases play important roles in multiple cellular functions, including DNA replication, transcription, DNA repair, and telomere maintenance.
Huiming Lu, Anthony J. Davis
doaj   +1 more source

Late presentation, MR imaging features and surgical treatment of Herlyn-Werner-Wunderlich syndrome (classification 2.2); a case report

BMC Women's Health, 2018
Background Herlyn-Werner-Wunderlich syndrome is a very rare congenital genitourinary anomaly characterized by uterus didelphys, blind hemivagina and ipsilateral renal agenesis. Case presentation Authors present a case of Herlyn-Werner-Wunderlich syndrome
Hidayatullah Hamidi, Nilab Haidary
doaj   +1 more source

Mixed State Entanglement and Quantum Error Correction [PDF]

, 1996
Entanglement purification protocols (EPP) and quantum error-correcting codes (QECC) provide two ways of protecting quantum states from interaction with the environment.
A. Aspect, A. Barenco, A. Einstein, A. Ekert, A. M. Steane, A. Peres, A. R. Calderbank, A. Wehrl, B. Schumacher, C. H. Bennett, C. H. Bennett, C. H. Bennett, C. H. Bennett, C. H. Bennett, C. H. Bennett, C. H. Bennett, Charles H. Bennett, D. Coppersmith, D. Deutsch, David P. DiVincenzo, H. Mabuchi, I. L. Chuang, J. F. Clauser, J. F. Clauser, J. S. Bell, John A. Smolin, M. Tinkham, N. Gisin, P. G. Kwiat, P. W. Shor, R. F. Werner, R. Jozsa, R. Laflamme, S. Popescu, S. Popescu, W. K. Wootters, William K. Wootters   +36 more
core   +3 more sources