Results 41 to 50 of about 906,171 (200)

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]

, 2016
Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio, Bimonte, V. M., Fittipaldi, Simona, Francomano, Davide, Greco, E. A., Lenzi, Andrea, Migliaccio, S., Papa, V., Wannenes, F.   +8 more
core   +1 more source

Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway

Frontiers in Cardiovascular Medicine, 2021
Background: Proliferation and migration of smooth muscle cells in the coronary artery contribute to the deterioration of coronary artery disease (CAD).Aim: This research was designed to study the function of Shexiang Baoxin pills (SBPs) on the ...
Lei Hua, Yaqing Zhou, Can Hou, Jiaxin Chen, Yanjun Wang, Sheng Zhang, Hanxiao Zhou, Shu He, Enzhi Jia   +8 more
doaj   +1 more source

Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins [PDF]

, 2008
Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail.
Deshaies, Raymond J., Elsasser, Suzanne, Finley, Daniel, Goh, Amanda M., Howley, Peter M., Verma, Rati, Walters, Kylie J.   +6 more
core   +6 more sources

Diagnostic efficacy of Brucella abortus strain RB51 in experimentally inoculated Sprague-Dawley rats using western blot assay

Journal of Infection in Developing Countries, 2008
Background: To investigate the diagnosis and efficacy of Brucella abortus strain RB51 (SRB51) in experimentally inoculated Sprague-Dawley (SD) rat using western blot assay.
Siddiqur Rahman, Byeong Kirl Baek
doaj   +1 more source

Decreased exosome-delivered miR-486-5p is responsible for the peritoneal metastasis of gastric cancer cells by promoting EMT progress

World Journal of Surgical Oncology, 2021
Background The present study aims to investigate the preliminary mechanism underlying the peritoneal metastasis of gastric cancer cells. Methods Exosomes from GC9811 cells (Con-Exo) and from GC9811-P cells (PM-Exo) were extracted by ultracentrifugation ...
Xian-Ming Lin, Zhi-Jiang Wang, Yu-Xiao Lin, Hao Chen   +3 more
doaj   +1 more source

Dibutyltin(IV) and Tributyltin(IV) Derivatives of meso-Tetra(4-sulfonatophenyl)porphine Inhibit the Growth and the Migration of Human Melanoma Cells [PDF]

, 2019
Melanoma is the most aggressive and deadly form of skin cancer, which is largely due to its propensity to metastasize. Therefore, with the aim to inhibit the growth and the metastatic dissemination of melanoma cells and to provide a novel treatment ...
Caterina Di Sano, Claudia Pellerito, Fabiana Di Leo, Francesca Costantini, Giovanna Barbieri, Tiziana Fiore   +5 more
core   +1 more source

p38MAPK Signaling Enhances Glycolysis Through the Up-Regulation of the Glucose Transporter GLUT-4 in Gastric Cancer Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Previous studies have shown that p38MAPK is involved in gastric cancer, yet the underlying mechanism remains unclear. Methods: q-PCR, Western blot and immunohistochemistry were used to explore the expression of PP2A and the ...
Jingjing Liu, Dacheng Wen, Xuedong Fang, Xudong Wang, Tianzhou Liu, Jiaming Zhu   +5 more
doaj   +1 more source

CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism. [PDF]

, 2018
CD44 is a single-pass cell surface glycoprotein that is distinguished as the first molecule used to identify cancer stem cells in solid tumors based on its expression.
Gao, Ruifang, Li, Dan, Li, Jun, Li, Xiru, Liu, Chen, Luo, Na, Qiao, Huan, Shen, Wenzhi, Stupack, Dwayne G, Wang, Juan, Xun, Jing, Zhou, Wei   +11 more
core  

Optimal activation of an endogenous gene by HOX11 requires the NH 2- terminal 50 amine acids [PDF]

, 1998
The HOX11 homeobox gene was first identified through studies of the t(7;10) and t(10;14) chromosomal translocations of acute T-cell leukemia. In addition, analysis of Hox11(-/-) mice has demonstrated a critical role for this gene in murine spleen ...
Masson, N., Greene, W.K., Rabbitts, T.H.
core   +2 more sources

Antibody responses to equine parapoxvirus reveal a re-emerging pattern

BMC Veterinary Research
Background Parapoxviruses (PPV) cause skin and mucous membrane signs to several animal species and humans worldwide. Equine parapoxvirus (EqPPV) was first detected in a sick horse in Finland in 2013.
Jenni Pettersson, Lev Levanov, Sanna Tervo, Katja Hautala, Kirsi Aaltonen, Mira Utriainen, Lauri Kareinen, Tuija Gadd, Tarja Sironen, Olli Vapalahti, Paula M. Kinnunen   +10 more
doaj   +1 more source