Acta Biochimica et Biophysica Sinica, 2023 Krüppel-like zinc-finger transcription factor 5 (KLF5) is a vital regulator of breast cancer (BC) onset and progression. The mechanism by which KLF5 regulates BC is still not clearly known.
Zhu Yiping +8 more
doaj +1 more source
Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence
Pharmaceuticals, 2020 Citrus hystrix (CH) is a beneficial plant utilized in traditional folk medicine to relieve various health ailments. The antisenescent mechanisms of CH extracts were investigated using human neuroblastoma cells (SH-SY5Y).
Nattaporn Pattarachotanant +1 more
doaj +1 more source
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer [PDF]
, 2016 The small GTPase Rab25 has been functionally linked to tumour progression and aggressiveness in ovarian cancer and promotes invasion in three-dimensional environments.
Chalmers, Anthony J. +3 more
core +1 more source
Retrovirology, 2004 Background The Sykes' monkey and related forms (Cercopithecus mitis) make up an abundant, widespread and morphologically diverse species complex in eastern Africa that naturally harbors a distinct simian immunodeficiency virus (SIVsyk).
Otsyula Moses G +5 more
doaj +1 more source
Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer [PDF]
, 2009 Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Arata Shimo +10 more
core +2 more sources
Scientific Data, 2021 Measurement(s) cell proliferation assay • Myoepithelial Cell • cell viability assay • protein expression assay Technology Type(s) cell counting technique • high content screen of cells treated with library of siRNAs • imaging technique • western blot ...
Hendrika M. Duivenvoorden +4 more
doaj +1 more source
Aberrant Polycystin-1 Expression Results in Modification of Activator Protein-1 Activity, whereas Wnt Signaling Remains Unaffected [PDF]
, 2004 Polycystin-1, the polycystic kidney disease 1 gene product, has been implicated in several signaling complexes that are known to regulate essential cellular functions. We investigated the role of polycystin-1 in Wnt signaling and activator protein-1 (
Arnould +37 more
core +3 more sources
Inhibiting P2Y12 receptor relieves LPS‐induced inflammation and endothelial dysfunction
Immunity, Inflammation and Disease, 2022 Background Acute lung injury (ALI) is characterized by abnormal inflammatory response without effective therapies. P2Y12 receptor (P2Y12R) plays a vital role in inflammatory response.
Xiuxia Han
doaj +1 more source
Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization [PDF]
, 2002 The Nf2 tumor suppressor gene product merlin is related to the membrane-cytoskeleton linker proteins of the band 4.1 superfamily, including ezrin, radixin, and moesin (ERMs). Merlin is regulated by phosphorylation in a Rac/cdc42-dependent fashion.
Eckman, Matthew S. +3 more
core +1 more source
Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells [PDF]
, 2018 Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands.
Agnusdei, Valentina +11 more
core +3 more sources