Complete Cocrystal Formation during Resonant Acoustic Wet Granulation: Effect of Granulation Liquids [PDF]
Pharmaceutics, 2021 The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules.
Ryoma Tanaka +5 more
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The Influence of Wet Granulation Parameters on the Compaction Behavior and Tablet Strength of a Hydralazine Powder Mixture [PDF]
Pharmaceutics, 2023 The aim of this paper was to describe the influence of high-shear wet granulation process parameters on tablet tensile strength and compaction behavior of a powder mixture and granules containing hydralazine.
Oliver Macho +6 more
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Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing [PDF]
Pharmaceutics, 2023 The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster +4 more
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Improved wet granulation techniques [PDF]
Farmacja Polska, 2020 Wet granulation is one of the most frequently used processes in the pharmaceutical industry to manufacture solid dosage forms. Wet granulation is helpful in tableting active substances that are not susceptible to the compression.
Monika Pastewska, Wiesław Sawicki
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Terahertz Spectroscopy for Non-Destructive Solid-State Investigation of Norfloxacin in Paper Tablets after Wet Granulation [PDF]
Pharmaceutics, 2023 (1) Background: Amorphous drug systems are an intensively studied approach to overcome the insufficient bioavailability of poorly soluble drugs. Here, paper tablets were studied, which were made from cellulose-based paper matrices loaded with norfloxacin.
Lara Heidrich +5 more
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Prediction of quality attributes (mechanical strength, disintegration behavior and drug release) of tablets on the basis of characteristics of granules prepared by high shear wet granulation. [PDF]
PLoS ONE, 2021 High shear wet granulation is commonly applied technique for commercial manufacturing of tablets. Granulation process for tablets manufacturing is generally optimized by hit and trial which involves preparation of granules under different processing ...
Amjad Khan
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Evaluation of Binders in Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 The binders povidone (Kollidon 30), copovidone (Kollidon VA64), hypromellose (Pharmacoat 606), and three types of hyprolose (HPC SSL-SFP, HPC SSL, and HPC SL-FP) were evaluated regarding their suitability in twin-screw wet granulation.
Claudia Köster +2 more
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Compression Density as an Alternative to Identify an Optimal Moisture Content for High Shear Wet Granulation as an Initial Step for Spheronisation [PDF]
Pharmaceutics, 2022 Pellet production is a multi-step manufacturing process comprising granulation, extrusion and spheronisation. The first step represents a critical control point, since the quality of the granule mass highly influences subsequent process steps and ...
Selina Ramm +5 more
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Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process [PDF]
Pharmaceutics, 2021 The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere +7 more
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Microwave-Assisted Wet Granulation for Engineering Rice Starch–Mannitol Co-Processed Excipients for Direct Compression of Orally Disintegrating Tablets [PDF]
PharmaceuticsBackground/Objectives: Enhancing excipient functionality through environmentally friendly and scalable processing methods is essential for improving the manufacturability and performance of orally disintegrating tablets (ODTs).
Karnkamol Trisopon, Phennapha Saokham
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