Particle-Scale Modeling to Understand Liquid Distribution in Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 Experimental characterization of solid-liquid mixing for a high shear wet granulation process in a twin-screw granulator (TSG) is very challenging. This is due to the opacity of the multiphase system and high-speed processing.
Ashish Kumar +4 more
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Parametric Study of Residence Time Distributions and Granulation Kinetics as a Basis for Process Modeling of Twin-Screw Wet Granulation [PDF]
Pharmaceutics, 2021 Twin-screw wet granulation is a crucial unit operation in shifting from pharmaceutical batch to continuous processes, but granulation kinetics as well as residence times are yet poorly understood.
Timo Plath +3 more
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Formulation, Characterization and Physicochemical Evaluation of Potassium Citrate Effervescent Tablets [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. Methods: In this study, 13 formulations were prepared
Fatemeh Fattahi, Abolfazl Aslani
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Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis [PDF]
Pharmaceutics, 2021 Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez +4 more
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Autoencoder-based inverse design and surrogate-based optimization of an integrated wet granulation manufacturing process [PDF]
International Journal of Pharmaceutics: XIn pharmaceutical manufacturing, integrating model-based design and optimization can be beneficial for accelerating process development. This study explores the utilization of Machine Learning (ML) techniques as a surrogate model for the optimization of ...
Ashley Dan, Rohit Ramachandran
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DEM modeling of high shear wet granulation of a simple system [PDF]
Asian Journal of Pharmaceutical Sciences, 2018 High shear wet granulation (HSWG) is one of the most poorly understood processes with known difficulties in optimization and scale up. The purpose of the current study is to develop a DEM model which can be applied under dynamic process conditions with ...
Saurabh Sarkar, Bodhisattwa Chaudhuri
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In situ wet pharmaceutical granulation captured using synchrotron radiation based dynamic micro-CT
Journal of Synchrotron Radiation, 2023 Synchrotron radiation based dynamic micro-computed tomography (micro-CT) is a powerful technique available at synchrotron light sources for investigating evolving microstructures. Wet granulation is the most widely used method of producing pharmaceutical
Xiao Fan Ding +3 more
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Pharmaceutics, 2021 Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier +2 more
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Advances in Twin-Screw Granulation
Pharmaceutics, 2021 Twin-screw granulation (TSG) is an emerging process technology that allows both wet and dry granulation of powders with a wide range of properties [...]
Valérie Vanhoorne, Ashish Kumar
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Cooling and Aggregation in Wet Granulates [PDF]
Physical Review Letters, 2009 Wet granular materials are characterized by a defined bond energy in their particle interaction such that breaking a bond implies an irreversible loss of a fixed amount of energy. Associated with the bond energy is a nonequilibrium transition, setting in as the granular temperature falls below the bond energy.
Ulrich, S. +5 more
openaire +5 more sources