Results 151 to 160 of about 53,418 (326)

Epstein–Barr Virus, Lower Vitamin D, Low Sun Exposure, and HLA‐DRB1*1501 Risk Variant Share Common Epigenetic Pathways Leading to Multiple Sclerosis Onset

Annals of Neurology, EarlyView.
Objectives Multiple sclerosis (MS) onset risk factors include Epstein–Barr virus (EBV) indices (including host response), lower serum 25‐vitamin D (25(OH)D) levels, low sun exposure, and HLA‐DRB1*1501. The underlying molecular mechanisms are unclear. Here, we examined mediation through differential DNA methylation (DNAm) to better understand possible ...
Steve Simpson‐Yap, Ellen Morwitch, Samuel A. Tanner, Sarah M. Thomson, Alex Eisner, Rod A. Lea, Trevor J. Kilpatrick, Jeannette Lechner‐Scott, Rodney J. Scott, Alexandre Xavier, Vicki E. Maltby, Robyn M. Lucas, Bruce V. Taylor, Brett A. Lidbury, Simon A. Broadley, Ingrid van der Mei, Mehari Woldemariam Merid, Boris Novakovic, Richard Saffery, Anna Karin Hedström, Pernilla Stridh, Tomas Olsson, Maja Jagodic, Lars Alfredsson, Anne‐Louise Ponsonby, for the Ausimmune Investigator Group, Caron Chapman, Alan Coulthard, Keith Dear, Terry Dwyer, Trevor Kilpatrick, Robyn Lucas, Tony McMichael, Anne‐Louise Ponsonby, Bruce Taylor, Patricia Valery, Ingrid van der Mei, David Williams   +37 more
wiley   +1 more source

Predicting cervical cancer DNA methylation from genetic data using multivariate CMMP

Canadian Journal of Statistics, EarlyView.
Abstract Epigenetic modifications link the environment to gene expression and play a crucial role in tumour development. DNA methylation, in particular, is gaining attention in cancer research, including cervical cancer, the focus of this study.
Hang Zhang, Steven Chen, Raymond Balise, Jiming Jiang, Nagi Ayad, J. Sunil Rao   +5 more
wiley   +1 more source

Construction of CeRNA regulatory network based on WGCNA reveals diagnosis biomarkers for colorectal cancer [PDF]

, 2022
Jun Xiang, Li Gao, Hao Yu Jing, Yun Xiao Liu, Hu Fei Wang, Ze Wen Chang, Shi Hao Liu, Lei Yu, Gui Yu Wang   +8 more
openalex   +1 more source

Pathogenic glycosyltransferase genes and potential therapeutic drugs in pressure overload‐induced heart failure

ESC Heart Failure, EarlyView.
Abstract Aims Protein glycosylation regulated by glycosyltransferases is an important type of post‐translational modification. The role of the glycosyltransferase genes (GTGs) in heart failure (HF) remains unclear and requires further investigation.
Jiahe Wu, Yi Lu, Xinchen Gao, Xiaorong Hu, Zhibing Lu, Chenze Li   +5 more
wiley   +1 more source

Peer Review #2 of "Identifying DUSP-1 and FOSB as hub genes in immunoglobulin A nephropathy by WGCNA and DEG screening and validation (v0.1)"

, 2022
L Wang
openalex   +1 more source

Global Stress Responses Identify the Functionally Divergent Regulators Required for Candida auris Commensalism and Pathogenicity

Exploration, EarlyView.
Candida auris is an emerging multidrug‐resistant fungal pathogen that poses a serious global health threat. In our study, we comprehensively delineate both the pan‐genomic and transcriptomic features of C. auris. Intriguingly, our findings reveal an unexpected alkaline pH‐dependent regulation required for C. auris virulence and commensalism mediated by
Chaoyue Xu, Wanxing Xu, Yushun Yuan, Xiaoqing Chen, Ouyang Mo, Zhe Yin, Xinhua Huang, Yuanyuan Wang, Lingfei Hu, Wenwen Xue, Yun Zou, Luyao Zhang, Kunlin Li, Yueru Tian, Jihong Liu, Sichu Xiong, Lei Wu, Yanmei Dong, Guangsheng Chen, Yuping Zhang, Zili Zhou, Ming Guan, Xiaotian Huang, Zhiyi He, Lin Zhong, Lingbing Zeng, Pei Hao, Xiaoqi Zheng, Changbin Chen, Ning‐Ning Liu, Dongsheng Zhou   +30 more
wiley   +1 more source

Enhancing postmenopausal osteoporosis: a study of KLF2 transcription factor secretion and PI3K-Akt signaling pathway activation by PIK3CA in bone marrow mesenchymal stem cells

Archives of Medical Science
Introduction Mesenchymal stem cells can develop into osteoblasts, making them a promising cell-based osteoporosis treatment. Despite their therapeutic potential, their molecular processes are little known.
Wenjie Ma, Chen Li
doaj   +1 more source

Gut microbial features can predict host phenotype response to protein deficiency. [PDF]

, 2018
Malnutrition remains a major health problem in low- and middle-income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N2 ) balance, due to the unavailability of amino acid for metabolism and unbalanced protein ...
Dugas, Lara R, Forrester, Terrence, Gilbert, Jack A, Layden, Brian T, Navarro, Guadalupe, Sharma, Anukriti   +5 more
core  

Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis

iMetaMed, EarlyView.
Integrative analysis of LC‐PTB patients pinpoints six biomarkers (ANK2, EPB42, CA1, HBB, HBD, MYL4) that reshape the immune microenvironment, offering new targets for diagnosis and treatment of lung cancer complicated by tuberculosis. ABSTRACT Coexisting lung cancer and pulmonary tuberculosis (LC‐PTB) is clinically challenging in diagnosis and ...
Ling Yang, Shanshan Li, Guangliang Bai, Longyan Li, Yuxi Li, Xuejiao Liang, Zhaoyang Ye, Linsheng Li, Li Zhuang, Jingzhi Guan, Wenping Gong   +10 more
wiley   +1 more source

Key Candidate Genes – VSIG2 of Colon Cancer Identified by Weighted Gene Co-Expression Network Analysis

Cancer Management and Research, 2021
Zhongze Cui,* Yangyang Li,* Shuang He, Feifei Wen, Xiaoyang Xu, Lizhen Lu, Shuhua Wu Department of Pathology, Binzhou Medical University Hospital, Binzhou, Shandong Province, People’s Republic of China*These authors contributed equally to ...
Cui Z, Li Y, He S, Wen F, Xu X, Lu L, Wu S   +6 more
doaj