Results 151 to 160 of about 43,312 (289)

Gut Microbiome Functional Reprogramming Reflects Divergent Social Strategies in a Wild Primate

Integrative Zoology, EarlyView.
Wild golden snub‐nosed monkeys employ divergent social strategies, forming reproductive one‐male units and bachelor all‐male units. We reveal that these social structures, intertwined with seasonal diets, drive distinct functional reprogramming in their gut microbiomes. This adaptive microbial plasticity plays a crucial role in primate socio‐ecological
Guanwei Lan, Xianjun Li, Zhantao Lu, Yue Zhang, Feifei Feng, Juan Liu, Wei Wu, Jiabin Liu, Yanshan Zhou, Jiang Gu, Rui Ma, Dunwu Qi   +11 more
wiley   +1 more source

Predictive Value of a Diagnostic Five-Gene Biomarker for Pediatric Sepsis

Journal of Inflammation Research
Yulong Xiao,1 Genhao Zhang2 1Department of Medical Laboratory, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Blood Transfusion, The First Affiliated Hospital of Zhengzhou University ...
Xiao Y, Zhang G
doaj  

Weighted Gene Co-Expression Network Analysis (WGCNA) in chorioallantois.

, 2019
Correlation (r) of each module identified by WGCNA to external factors (Gestation and fetal gender). Color and depth of color corresponds to depth of correlation, with positive correlation indicated in red, negative correlation indicated in blue ...
Pouya Dini (6109472), Hossam El-Sheikh Ali (7866251), Theodore Kalbfleisch (59077), Barry A. Ball (3912946), Shavahn C. Loux (3912937)   +4 more
core   +1 more source

WGCNA and ferroptosis genes in OSCC: unraveling prognostic biomarkers and therapeutic targets

Discover Oncology
Oral squamous cell carcinoma (OSCC) is the predominant type of oral cancer, with over 370,000 new cases and approximately 170,000 deaths annually worldwide. Despite therapeutic advancements, OSCC mortality rates have been increasing, underscoring the need for improved prognostic models and therapeutic targets.We integrated transcriptomic and clinical ...
Ke Liu, Jiannan Yu, Xuanxi Huang, Hongyan Gao, Jing Wang   +4 more
openaire   +3 more sources

Machine Learning‐Derived Immune Gene Signature Predicts Prognosis and Therapeutic Vulnerabilities in Multiple Myeloma

Cancer Science, EarlyView.
An immune‐related 12‐gene signature developed through integrative machine learning stratified overall survival across multiple myeloma cohorts and remained independently associated with outcome. Single‐cell, somatic mutation, and transcriptome‐based drug‐response analyses further linked the signature to multicellular bone marrow context, distinct ...
Kai Wang, Chenfei Zhao, Jingru Shi, Shiwei Liu, Yi Chen, Jujuan Wang, Zhengxu Sun, Sanmei Wang, Lei Fan, Jin Fan, Xiaoyan Qu   +10 more
wiley   +1 more source

Construction of mRNAsi related module genes using WGCNA.

(A) Analysis of scale-free exponent and average connectivity of various soft threshold powers; (B) Cluster dendrogram of the co-expression network modules; (C) Module thresholds for WGCNA analysis; (D) The number of genes in each module. (PDF)
Lixia Liu (447585), Naipeng Cui (7369379), Hao Li (31608), Wenwen Liu (195246), Zichao Wang (3817903), Meng Zhang (154027), Miaomiao Gu (2356210), Bin Liu (5899), Xin Xi (793014), Zhou Shen (3398834), Shan Jiang (121292), Guixin Di (18404456), Yanan Wang (123548)   +12 more
core   +1 more source

Functional and transcriptomic analyses in Neurospora crassa reveal a crucial role for the N‐glycoprotein deglycosylation process in fungal homeostasis

The FEBS Journal, EarlyView.
In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras, Tanim Jabid Hossain, Magnus Karlsson, Georgios Tzelepis   +3 more
wiley   +1 more source

Murine Model Insights: Identifying Dusp15 as a Novel Biomarker for Diabetic Cardiomyopathy Uncovered Through Integrated Omics Analysis and Experimental Validation

Diabetes, Metabolic Syndrome and Obesity
Lingling Zhu,1,* Ya Dong,2,* Hang Guo,1 Jie Qiu,1 Jun Guo,1 Yonghui Hu,3 Congqing Pan1 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of ...
Zhu L, Dong Y, Guo H, Qiu J, Guo J, Hu Y, Pan C   +6 more
doaj  

Identification of SORT1 as a Key Regulator of Antigen Presentation in CD16+ Monocytes During Septic Shock via Multi‐Omics and In Silico Gene Knockout Analysis [PDF]

Immun Inflamm Dis
ABSTRACT Objective This study aimed to screen and identify hub genes correlated with septic shock through integrative analyses of bulk transcriptomics, machine learning, weighted gene co‐expression network analysis (WGCNA), single‐cell transcriptomics, and in silico gene knockout, and further dissect their underlying immunoregulatory mechanisms ...
Wu S, Zhang J, Guo S, Hu Y, Shen H, Xu Y, Yang B.   +6 more
europepmc   +2 more sources

Network topological properties of regulatory networks inferred using RulNet, WGCNA and Pearson methods.

, 2015
Network topological properties of regulatory networks inferred using RulNet, WGCNA and Pearson methods.
Pierre Martre (159412), Zhanwu Dai (668233), Marie Pailloux (741195), Jonathan Vincent (741191), Benjamin Gouriou (741192), Catherine Ravel (741193), Jean-Marc Petit (741194)   +6 more
core   +1 more source