Results 151 to 160 of about 33,188 (253)

Identification of diagnostic biomarkers for neonatal necrotizing enterocolitis via machine learning screening and single‐cell virtual gene knockout validation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Integrated machine learning screening of five gene expression omnibus datasets and 113 algorithm combinations identified three candidate diagnostic biomarkers for neonatal necrotizing enterocolitis: SLC26A3 (downregulated), CCL20, and CXCL5 (both upregulated). Single‐cell RNA sequencing localized CCL20 upregulation predominantly to macrophages.
Xue Liu, Wenqiang Sun, Zengxue Hu, Yihui Li, Jingtao Bian, Xueping Zhu   +5 more
wiley   +1 more source

A Multi-Network Approach Identifies Proteins Related to Dendritic Spines in Alzheimer's Disease. [PDF]

eNeuro
Hobby EL, Weber AJ, Liu E, Hurst C, Greathouse KM, Gaiteri C, Seyfried NT, Herskowitz JH.   +7 more
europepmc   +1 more source

Species‐specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Cross‐species network analysis identifies CCN1/2 as conserved hubs linking extracellular matrix assembly, growth factor signaling, and mechanosensitive pathways during chondrogenesis, guiding model selection and informing CCN‐targeted cartilage regeneration strategies.
Zhangzheng Wang, Judit Vágó, Roland Takács, Szilárd Póliska, Ee Hyun Kim, Eun‐Jung Jin, Satoshi Kubota, Celina G Kleer, Bernard Perbal, Csaba Matta   +9 more
wiley   +1 more source

Bioinformatics Identification and Molecular Docking Validation of Post-Translational Modification-Related Hub Genes as Diagnostic Biomarkers and Therapeutic Targets in Myocardial Fibrosis. [PDF]

Int J Mol Sci
Yu X, Du X, Zuo G, Liu X.
europepmc   +1 more source

1 Hz Low‐Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon‐γ Signaling‐Dependent Microglial Synaptic Phagocytosis in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
In a mouse model of recurrent seizures, 1 Hz rTMS exerted neuroprotective effects by enhancing IFN‐γ‐dependent STAT2 activation in microglia and reducing CADM1/2/3 expression, thereby limiting excessive synaptic phagocytosis. Notably, co‐treatment with a neutralizing antibody against IFN‐γ abolished the 1 Hz rTMS‐induced STAT2 activation and the ...
Donghui Lin, Duan Wang, Nong Xiao
wiley   +1 more source

Transcriptomic Analyses and Weighted Gene Co-Expression Network Analysis (WGCNA) Identify Key Drought-Responsive Genes in Rice Roots (<i>Oryza sativa</i> L.) Under PEG Treatment. [PDF]

Plants (Basel)
Yan S, Jiang Z, Liu X, Huang Y, Li N, Wang W, Mur LAJ, Liu Z, Lei D, Zhang X.   +9 more
europepmc   +1 more source

Disease modules identification in heterogenous diseases with WGCNA method

, 2019
The widely collected and analyzed genetic data help in understanding the underlying mechanisms of heterogeneous diseases. Cellular components interact in a network fashion where genes are nodes and edges are the interactions. The failure in individual genes lead to dys-regulation of sub-groups of genes which causes a disease phenotype, and this dys ...
openaire   +1 more source

Exploring the Lung–Liver Axis in Pulmonary Arterial Hypertension

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Among PAH patients without liver disease, subclinical liver dysfunction quantified by MELD‐Na associates with higher pulmonary vascular resistance and inflammatory activation of the pulmonary endothelium, characterized by an IL‐6‐centered transcriptional network enriched for leukocyte chemotaxis.
Navneet Singh, Jordan Lawson, Ashok Ragavendran, Somanshu Banerjee, Andy Hon, Alejandro Vega, Jason Hong, Christopher J. Mullin, Mandy Pereira, Allyson Sherman‐Roe, Alexander T. Jorrin, Tiffaney Cayton, Gregory Fishbein, James R. Klinger, William M. Oldham, Rui‐Sheng Wang, Zhiyu Dai, Michael Fallon, Elizabeth O. Harrington, Olin D. Liang, Soban Umar, Corey E. Ventetuolo   +21 more
wiley   +1 more source

RNA sequencing reveals lncRNAs that specifically regulate unsaturated fatty acid generation in buffaloes. [PDF]

Arch Anim Breed
Zeng X, Tian H, Wang H, Zou F, Mo H, Lu X, Yang C, Shi D, Shang J, Huang J.   +9 more
europepmc   +1 more source

Enteromorpha prolifera Polysaccharide Alleviates Type 2 Diabetes via the Gut Microbiota–Liver Axis to Modulate Cholesterol Metabolism

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Enteromorpha prolifera polysaccharides may help restore lipid metabolism homeostasis by gently remodeling the gut microbiota to enrich beneficial bacteria and SCFAs, which in turn appears to modulate hepatic functions through the portal vein by downregulating cholesterol synthesis and promoting its metabolism. This coordinated process potentially leads
Liuying Zhu, Xusheng Wen, Wenrong Zhu, Xueqian Hu, Yanqun Xu, Xin Peng   +5 more
wiley   +1 more source