Results 191 to 200 of about 43,312 (289)

Identification of Neutrophil Extracellular Trap-Related Gene Expression Signatures in Ischemia Reperfusion Injury During Lung Transplantation: A Transcriptome Analysis and Clinical Validation

Journal of Inflammation Research
Jiameng Gao,1,2,* Zhiyuan Zhang,1,2,* Jing Yu,1,2,* Nan Zhang,1,2 Yu Fu,1,2 Xuemei Jiang,1,2 Zheyu Xia,3 Qingqing Zhang,1,2 Zongmei Wen1,2 1Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University ...
Gao J, Zhang Z, Yu J, Zhang N, Fu Y, Jiang X, Xia Z, Zhang Q, Wen Z   +8 more
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Integrated Bulk and Single-Nucleus Transcriptomics Characterizes the Developmental and Regional Specialization of Chicken Abdominal Fat-Associated Tissue. [PDF]

Animals (Basel)
Zhang S, Zhang Q, Wang J, Li Z.
europepmc   +1 more source

Proteomic dysregulation associated with cerebral amyloid angiopathy

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA) is characterized by impaired vascular amyloid‐β clearance, distinct from Alzheimer's disease (AD), underscoring the need to clarify its molecular basis for predicting therapy‐related amyloid‐related imaging abnormalities. METHODS We analyzed post‐mortem brain proteomics from Religious Orders Study
Sang‐Won Han, Young Ho Park, Jung‐Min Pyun, Paula J. Bice, David A. Bennett, Shahram Oveisgharan, Andrew J. Saykin, SangYun Kim, Kwangsik Nho   +8 more
wiley   +1 more source

Integrating Structural Characterization, Network Pharmacology, and Experimental Validation Reveals the Anti‐Liver Aging Mechanism of Acorus tatarinowii Polysaccharides

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
ATP is extracted and structurally characterized. Network pharmacology, WGCNA and machine learning identify TLR4 and Nrf2 as core targets. In D‐gal‐induced aging rats, ATP relieves hepatic atrophy and steatosis, suppresses hepatic TLR4, NF‐κB, and HO‐1 expression, and up‑regulates Nrf2 expression, showing its promising potential for counteracting ...
Yikuan Du, Jiahui Li, Yuting Lin, Jiawen Luo, Weien Zhang, Feng Chen, Zhonghan Liang, Jiaxin Zhu, Jiaqi Li, Chenyue Yuan, Yidian Liu, Xuan Liu, Yang Zhang, Qiaohong Zhong, Yanling Jiang, Songsong Yang, Chunling Ma, Zhi Chen, Chun Yang   +18 more
wiley   +1 more source

Machine Learning, scRNA-Seq and Biological Experiments Identify Hub Genes Responsible for Ischemia-Reperfusion Injury in Steatotic Liver Allografts. [PDF]

J Inflamm Res
Lu K, Zhao YM, Chai KY, Lyu Y, Zhang XF.
europepmc   +1 more source

Artificial Intelligence in Gastric Cancer: Diagnostic, Prognostic, and Predictive Developments, Evidence Maturity, and Translational Challenges

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Gastric cancer (GC) remains a major global health burden characterized by substantial heterogeneity in diagnosis, prognosis, and treatment response. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL), has been increasingly investigated for the analysis of endoscopic images, radiological scans, whole‐
Chong Chen, Weisong Xu, Tong Wu, Junpeng Zhao, Xuebing Xu, Mingbing Xiao, Kang Xu   +6 more
wiley   +1 more source

Integrated Bioinformatics Exploration and Preliminary Clinical Verification for the Identification of Crucial Biomarkers in Severe Cases of COVID-19

Journal of Inflammation Research
Zhisheng Huang,1,2 Zuowang Cheng,3 Xia Deng,4 Ying Yang,5 Na Sun,5 Peibin Hou,5 Ruyue Fan,5 Shuai Liu6,7 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of ...
Huang Z, Cheng Z, Deng X, Yang Y, Sun N, Hou P, Fan R, Liu S   +7 more
doaj  

Transcriptomic Dynamics and ECM Remodeling During Postnatal Testicular Maturation in the Tianzhu White Yak. [PDF]

Animals (Basel)
Shi Y, Shi B, Qi Y, Cui C, Zhang M, Luo Z, Ma Y, Hu J.   +7 more
europepmc   +1 more source

Fingolimod Alleviates Neuroinflammation and Blood–Brain Barrier Disruption in Epilepsy by Upregulating S1PR5 and Inhibiting the Rho/ROCK/NF‐κB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Fingolimod alleviates epilepsy by restoring S1PR5 expression and suppressing the Rho/ROCK/NF‐κB pathway, thereby reducing neuroinflammation, preserving blood–brain barrier integrity, and attenuating seizure activity. ABSTRACT Objective This study aimed to clarify the role of sphingosine‐1‐phosphate receptor 5 (S1PR5) in epileptic pathogenesis and the ...
Chen Zhang, Yanli Duan, Mengmeng Ma, Lin Xu, Wei‐Na Jin, Zhuoran Zhang   +5 more
wiley   +1 more source

Exploration of Potential Biomarkers for Type 2 Diabetes by UPLC-QTOF-MS and WGCNA of Skin Surface Lipids

Clinical, Cosmetic and Investigational Dermatology, 2022
Li H, Ma Y, Feng N, Wang W, He C
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