Results 181 to 190 of about 33,188 (253)

Oral Immunotherapy Induces Shift in lncRNA Expression Modulating Allergen‐Specific Immune Responses

Allergy, Volume 81, Issue 6, Page 2111-2122, June 2026.
We used PBMC transcriptome from 50 hen's egg‐allergic patients to study the role of lncRNA in OIT. Positive correlation was found between 17 lncRNAs and the IL‐4/IL‐13 pathway in vivo, and the expression of the selected lncRNA aligned with CXCL8 upon PBMC egg‐restimulation.
Olivia Liong, Kati Palosuo, Victoria Hinkkanen, Vittorio Fortino, Mika J. Mäkelä, Piia Karisola   +5 more
wiley   +1 more source

Shared diagnostic biomarkers in metabolic syndrome and coronary artery disease identified by integrated bioinformatics and machine learning. [PDF]

Endocr Connect
Wang N, Hu K, Zhang S, Zhao H, Pan T, Wang T, Zhang Y, Liu X.   +7 more
europepmc   +1 more source

Transcriptomic analysis reveals lipid metabolism and macrophage involvement associated with nintedanib treatment in a rat bleomycin model

British Journal of Pharmacology, Volume 183, Issue 12, Page 3395-3408, June 2026.
In this study, nintedanib reduced lung fibrosis in a rat double‐hit bleomycin‐induced model. Transcriptomic analysis revealed two key gene signatures related to the effect of the molecule: one involving mesenchymal cells affecting known fibrotic pathways and another linking mainly macrophages to lipid metabolism.
Martina Bonatti, Vanessa Pitozzi, Paola Caruso, Silvia Pontis, Maria Gloria Pittelli, Caterina Frati, Denise Madeddu, Federico Quaini, Costanza Anna Maria Lagrasta, Ilaria Minato, Emanuela Bocchi, Maurizio Civelli, Gino Villetti, Marcello Trevisani, Barbara Montanini   +14 more
wiley   +1 more source

Uncovering Prognostic Biomarkers Underlying Hepatocellular Carcinoma Through Integrative Multi-Omics and a Network-Based Approach. [PDF]

Int J Mol Sci
Rahmani AH, Beg A, Sarwar T, Khan AA.
europepmc   +1 more source

Multi‐Omics Integration Reveals Incomplete Reactivation of Developmental Cell‐Cycle Programs in Adult Human Infarcted Hearts

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Jieran Lyu, Yuki Kuramoto, Jun Li, Jong‐Kook Lee, Kyoko Hidaka, Yasushi Sakata   +5 more
wiley   +1 more source

Modular control of orchid beauty: co-expression networks orchestrate organ development and evolution in Phalaenopsis flower. [PDF]

Plant Mol Biol
Lucibelli F, Carfora A, Varone M, Volpe G, Di Lillo P, Mazzucchiello SM, Saccone G, Salvemini M, Aceto S.   +8 more
europepmc   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, Volume 59, Issue 6, June 2026.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Sinomenine Regulates PSMB9 to Mediate Therapeutic Effects in Rheumatoid Arthritis. [PDF]

Cells
Zhang C, Lio C, Li N, Yu Y, Luo J.
europepmc   +1 more source

Inhibition of Fibroblast Activation Protein‐α Ameliorates Intervertebral Disc Degeneration via Reduced Vascular Invasion in Cartilage Endplate

Cell Proliferation, Volume 59, Issue 6, June 2026.
Schematic illustration showing that FAP‐α promoted angiogenesis, cytokine release and ECM degradation in the CEP degeneration of the intervertebral disc through upregulating the PI3K/Akt/HIF‐1α/VEGFA pathway. ABSTRACT Intervertebral disc degeneration (IDD) is a primary cause of low back pain, with the development of new blood vessels being a key ...
Hao‐Wei Xu, Sheng‐Jie Chang, Shuo Wang, Xiao‐Wei Liu, Shan‐Jin Wang   +4 more
wiley   +1 more source

Exploration of schizophrenia-associated gene modules using graph theory, co-expression networks, and dimensionality reduction. [PDF]

PLoS One
Bampos C, Megalooikonomou V.
europepmc   +1 more source