Results 201 to 210 of about 43,312 (289)

Identification of angiogenesis-related genes in the diagnosis of benign prostatic hyperplasia using bioinformatics analysis. [PDF]

Transl Androl Urol
Cui M, Kostadinovic K, Meng Q, Bai T, Gu Y, Liu S.   +5 more
europepmc   +1 more source

Disease modules identification in heterogenous diseases with WGCNA method

, 2019
The widely collected and analyzed genetic data help in understanding the underlying mechanisms of heterogeneous diseases. Cellular components interact in a network fashion where genes are nodes and edges are the interactions. The failure in individual genes lead to dys-regulation of sub-groups of genes which causes a disease phenotype, and this dys ...
openaire   +1 more source

Transcriptomic profiling reveals conserved stage‐associated programs across gastrointestinal adenocarcinomas

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Abstract Background Gastrointestinal (GI) adenocarcinomas exhibit substantial molecular heterogeneity despite their shared epithelial origin and anatomical continuity. Whether these anatomically distinct cancers share conserved transcriptomic programs associated with pathological stage remains unclear.
Wynston Jay Abenojar, Ron Jacob Avila, Po‐Wei Tsai, Lemmuel Tayo   +3 more
wiley   +1 more source

Identification of ion homeostasis-related genes as diagnostic biomarkers for pulmonary arterial hypertension via WGCNA and machine learning. [PDF]

Front Genet
Chen Y, Chen Q, Zheng S.
europepmc   +1 more source

USP25 stabilises GLI1 through K48‐linked deubiquitination within a reciprocal regulatory circuit in osteoarthritis models

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
GLI1‐centred USP25‐GLI1 reciprocal regulation in OA‐relevant models. Hedgehog/GLI1 signalling transcriptionally reinforces USP25 expression, while USP25 deubiquitinates and stabilises GLI1. This reciprocal circuit is associated with inflammatory and cartilage‐catabolic changes in the tested models.
Qian Zhang, Yinyan Ye, Yijie Huang, Jun Li, Dongfeng Huang   +4 more
wiley   +1 more source

Circulating Metabolites Associated with Prothrombin Time in Children with Congenital Heart Disease: An Untargeted Metabolomics Study. [PDF]

Metabolites
Li S, Watson D, Jorgenson A, Adelekan Z, Garland K, Deonovic B, Burns L, Tang W, Overman DM, Huntley MT.   +9 more
europepmc   +1 more source

Single‐cell multi‐omics characterises transcriptional and chromatin accessibility heterogeneity of immune cells in allergic rhinitis

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
Key Points 1. SAR and PAR showed distinct immune landscapes. 2. Macro_CCL3 showed phenotype‐specific inflammatory and antigen‐presentation features. 3. CD8_Trm displayed subtype‐associated chromatin accessibility linked to cytotoxicity‐related signatures. 4.
Yisha Wu, Zhihan Xu, Shikai Han, Zhongzhen Liu, Rui Dong, Chuanyu Liu, Jianhua Yin, Jinmei Xue   +7 more
wiley   +1 more source

Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation

International Journal of General Medicine
Hai Li,1,2 Dongnan Sun,3 Kai Jin,4 Xudong Wang1 1Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Basic and Translational Medicine on Head & Neck Cancer, Key ...
Li H, Sun D, Jin K, Wang X
doaj  

Integrative RNA-Seq Analysis Reveals Stress Type-Dependent lncRNA-Centered Co-Expression Networks Across Human Cellular Stress Contexts. [PDF]

Int J Mol Sci
Anastasiadi C, Kasapi A, Sentementes I, Gouzouasis V, Tsifintaris M, Giannakakis A.   +5 more
europepmc   +1 more source

Plant‐Derived Polyphenol Salvianolic Acid B Attenuates Cardiomyocyte Pyroptosis by Modulating the MMP12–NLRP3 Signaling Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
HG induces MMP12 upregulation in AC16 cardiomyocytes, which activates the NLRP3 inflammasome, triggers GSDMD‐mediated pyroptosis, and promotes the release of inflammatory cytokines. Sal B alleviates cardiomyocyte damage by modulating MMP12, while MMP12 overexpression abrogates this protective effect.
Zilong Xie, Zhi‐Kai Yang, Longhui Zheng, Pinghua Wu, Shengxian Chen, Xiaotong Ye, Yi Gao   +6 more
wiley   +1 more source